Differential regulation of cardiac adrenomedullin and natriuretic peptide gene expression by AT1 receptor antagonism and ACE inhibition in normotensive and hypertensive rats

Journal of Hypertension

Volumn 17, Issue 11, 1999, Pages 1543-1552

  Magga, Jarkko ^a   Kalliovalkama, Jarkko ^b   Romppanen, Hannu ^a   Vuolteenaho, Olli ^a   Pörsti, Ilkka ^b,c   Kähönen, Mika ^b,c   Tolvanen, Jari Petteri ^b   Ruskoaho, Heikki ^a  

^a UNIVERSITY OF OULU   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Adrenomedullin; Angiotensin II; Blood pressure; Cardiac gene expression; Natriuretic peptides; Rat; Ventricular hypertrophy

Indexed keywords

ADRENOMEDULLIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; LOSARTAN; MESSENGER RNA;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; GENE EXPRESSION; HEART; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HEMODYNAMICS; HYPERTENSION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE;

EID: 0032736861     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199917110-00006     Document Type: Article

References (47)

1. Nadal-Ginard B, Mahdavi V. Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches. J Clin Invest 1989; 84:1693-1700.
2. Parker TG, Schneider MD. Growth factors, proto-oncogenes, and plasticity of the cardiac phenotype. Ann Rev Physiol 1991; 53:179-200.
3. Chien KR, Knowlton KU, Zhu H, Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiological response. FASEB J 1991; 5:3037-3046.
4. Cooper G. Basic determinants of myocardial hypertrophy: a review of molecular mechanisms. Annu Rev Med 1997; 48:13-23.
5. Nakao K, Ogawa Y, Suga S, Imura H. Molecular biology and biochemistry of the natriuretic peptide system. I: natriuretic peptides. J Hypertens 1992; 10:907-912.
6. Ruskoaho H. Atrial natriuretic peptide: synthesis, release, and metabolism. Pharmacol Rev 1992; 44:479-602.
7. de Bold AJ, Bruneau BG, Kuroski de Bold ML. Mechanical and neuro-endocrine regulation of the endocrine heart. Cardiovasc Res 1996; 31:7-18.
8. Magga J, Marttila M, Mäntymaa P, Vuolteenaho O, Ruskoaho, H. Brain natriuretic peptide in plasma, atria, and ventricles of vasopressin- and phenylephrine-infused conscious rats. Endocrinology 1994; 134:2505-2515.
9. Sadoshima J, Izumo S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 1997; 59:551-571.
10. Sadoshima J, Izumo S. Molecular characterization of Ang II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT, receptor subtype. Circ Res 1993; 73;413-423.
11. Sadoshima J, Xu Y, Slayter HS, Izumo S, Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 1993; 75:977-984.
12. Dunn FG, Oigman W, Venture HO, Messerli FH, Kobrin IX, Frohlich ED. Enalapril improves systemic and renal homodynamics and allows regression of left ventricular mass in essential hypertension. Am J Cardiol 1984; 53:105-108.
13. Sen S, Tarazi RC, Bumpus FM. Effect of converting enzyme inhibitor (SQ14,225) on myocardial hypertrophy in spontaneously hypertensive rats. Hypertension 1980, 2:169-176.
14. Kojima M, Shiojima I, Yamazaki T, Komuro I, Zou Z, Wang, Y, et al. Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cerdiomyocyte hypertrophy in vitro. Circulation 1994; 89:2204-2211.
15. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993; 192:553-560.
16. Schell DA, Vari RC, Samson WK. Adrenomedullin: a newly discovered hormone controlling fluid and electrolyte homeostasis. Trends Endocrinol Metab 1996; 7:7-13.
17. Richards AM, Nicholls MG, Lewis L, Lainchbury JG. Adrenomedullin. Clin Sci 1996; 1:3-16.
18. Sakata J, Shimokubo T, Kitamura K, Nakamura S, Kangawa K, Matsuo H, et al. Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide. Biochem Biophys Res Commun 1993; 195:921-927.
19. Jougasaki M, Wei CM, McKinley LJ, Burnett JC Jr. Elevation of circulating and ventricular adrenomedullin in human congestive heart failure. Circulation 1995; 92:286-289.
20. Owji AA, Smith DM, Coppock HA, Morgan DGA, Bhogal R, Ghatel MA, et al. An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat. Endocrinology 1995; 136:2127-2134.
21. Ishimitsu T, Nishimiki T, Saito Y, Kitamura K, Eto T, Kangawa K, et al. Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure. J Clin Invest 1995; 94:2158-2161.
22. Romppanen H, Marttila M, Magga J, Vuolteenaho O, Kinnunen P, Szokodi I, et al. Adrenomedullin gene expression in the rat heart is stimulated by acute pressure overload: blunted effect in experimental hypertension. Endocrinology 1997; 138:2636-2639.
23. Jougasaki M, Stevens T, Borgeson D, Luchner A, Redfield M, Burnett JC Jr. Adrenomedullin in experimental congestive heart failure: cardiorenal activation, Am J Physiol 1997; 273:R1392-R1399.
24. Kaiser M, Shimada Y, Smith P, Kelly M, Mahadeva H, Adams M, et al. Differential regulation of ventricular adrenomedullin and atrial natriuretic peptide gene expression in pressure and volume overload in the rat. Clin Sci 1998; 94:359-365.
25. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979; 18:5294-5299.
26. Ogawa Y, Nakao K, Mukoyama M, Hosoda K, Shirakami GX, Arai H, et al. Natriurotic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats. The ventricle is a major site of synthesis and secretion of brain natriuretic peptide. Circ Res 1991; 69:491-500.
27. Flynn TG, Davies PL, Kennedy BP, de Bold ML, de Bold AJ. Alignment of rat cardionatrin sequences with the preprocardionatrin sequence from complementary DNA. Science 1985; 228:323-325.
28. Fort P, Marty L, Piechaczyk M, el Sabrouty S, Dani CX, Jeanteur P, et al. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucl Acids Res 1985; 13:1431-1442.
29. Kinnunen P, Vuolteenaho O, Ruskoaho H. Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching. Endocrinology 1993; 132:1961-1970.
30. Vuolteenaho O, Arjamaa O, Ling N. Atrial natriuretic polypeptides (ANP): rat atria store high molecular weight precursor but secrete processed peptides of 25-35 amino acids. Biochem Biophys Res Commun 1985; 129:82-88.
31. Trippodo NC, Frohlich ED. Similarities of genetic (spontaneous) hypertension: man and rat. Circ Res 1981; 48:309-318.
32. Pfeffer JM, Pfeffer MA, Mirsky I, Braunwald E. Regression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat. Proc Natl Acad Sci USA 1982; 79:3310-3314.
33. Arvola P, Ruskoaho H, Wuorela H, Pekki A, Vapaatalo H, Pörsti I. Quinapril treatment and arterial smooth muscle responses in spontaneously hypertensive rats. Br J Pharmacol 1993; 108:980-990.
34. Nunez E, Hosoya K, Susic D, Frohlich. Enalapril and losartan reduced cardiac mass and improved coronary hemodynamics in SHR. Hypertension 1997; 29 (pt 2):519-524.
35. Azizi M, Levy B, Salzmann JL, Cerol ML, Poitevin P, Menard J, et al. Long-term cardiac effects of hypotensive agents in normotensive mature rats: comparison of beta-blocking agent and converting enzyme inhibition. J Cardiovasc Pharmacol 1989; 13:691-701.
36. 1 receptor antagonist, an ACE inhibitor and a calcium channel antagonist on cardiac gene expressions in hypertensive rats. Br J Pharmacol 1996; 118:549-556.
37. Ogawa T, Linz W, Stevenson M, Bruneau BG, Kuroski de Bold ML, Chen JH, et al. Evidence for load-dependent and load independent determinants of cardiac natriuretic peptide production. Circulation 1996; 93:2059-2067.
38. 1 receptor antagonists in vivo and in vitro. Circulation 1997; 96:3053-3062.
39. Marttila M, Vuolteenaho O, Ganten D, Nakao K, Ruskoaho H. Synthesis and secretion of natriuretic peptides in the hypertensive TGR(mREN-2)27 transgenic rat. Hypertension 1996; 28:995-1004.
40. Arai H, Nakao K, Saito Y, Morii N, Sugawara A, Yamada T, et al. Augmented expression of atrial natriuretic polypeptide gene in ventricles of spontaneously hypertensive rats (SHR) and SHR-stroke prone. Circ Res 1988; 62:926-930.
41. Ruskoaho H, Kinnunen P, Taskinen T, Vuolteenaho OX, Leppäluoto J, Takala TE. Regulation of ventricular atrial natriuretic peptide release in hypertrophied rat myocardium. Effects of exercise. Circulation 1989; 80:390-400.
42. Matsubara H, Mori Y, Yamamoto J, Inada M, Diabetes-induced alterations in atrial natriuretic peptide gene expression in Wistar-Kyoto and spontaneously hypertensive rats. Circ Res 1990; 67:803-813.
43. Kinnunen P, Taskinen T, Järvinen M, Ruskoaho H. Effect of phorbol ester on the release of atrial natriuretic peptide from the hypertrophied rat myocardium. Br J Pharmacol 1991; 102:458-461.
44. Shimokubo T, Sakata J, Kitamura K, Matsuo H, Eto T. Adrenomedullin: changes in circulating and cardiac tissue concentration in Dahl-sensitive rats on a high-salt diet. Clin Exp Hypertens 1996; 18:949-961.
45. Shimokubo T, Sakata J, Kitamura K, Kangawa K, Matsuo H, Eto T. Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension. Life Sci 1995; 57:1771-1779.
46. Jougasaki M, Rodeheffer R, Redfield M, Yamamoto K, Wei C-M, Mackinley L, et al. Cardiac secretion of adrenomedullin in human heart failure. J Clin Invest 1996; 97:2370-2376.
47. Szokodi I, Kinnunen P, Tavi P, Weckström M, Toth M, Ruskoaho H. Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide, Circulation 1998; 97:1062-1070.