메뉴 건너뛰기




Volumn 20, Issue 1, 1999, Pages 29-44

Signaling of neuronal cell death by the p75NTR neurotrophin receptor

Author keywords

Apoptosis; Bcl 2 family; Caspase; Cell death; Knockout; Nerve growth factor; Neuronal survival; Neurotrophin; p75NTR; Signaling

Indexed keywords

CASPASE; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE;

EID: 0032736538     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02741363     Document Type: Article
Times cited : (34)

References (117)
  • 1
    • 0030907924 scopus 로고    scopus 로고
    • Signal transduction by the neurotrophin receptors
    • Kaplan D. R. and Miller F. D. (1997) Signal transduction by the neurotrophin receptors. Curr. Opinion. Cell Biol. 9, 213-221.
    • (1997) Curr. Opinion. Cell Biol. , vol.9 , pp. 213-221
    • Kaplan, D.R.1    Miller, F.D.2
  • 4
    • 0026766860 scopus 로고
    • The nerve growth factor family of receptors
    • Meakin S. O. and Shooter E. M. (1992) The nerve growth factor family of receptors. Trends Neurosci. 15, 323-331.
    • (1992) Trends Neurosci. , vol.15 , pp. 323-331
    • Meakin, S.O.1    Shooter, E.M.2
  • 5
    • 0028916050 scopus 로고
    • A potential interaction of p75 and trkA NGF receptors revealed by affinity crosslinking and immuno-precipitation
    • Huber L. J. and Chao M. V. (1995) A potential interaction of p75 and trkA NGF receptors revealed by affinity crosslinking and immuno-precipitation. J. Neurosci. Res. 40, 557-563.
    • (1995) J. Neurosci. Res. , vol.40 , pp. 557-563
    • Huber, L.J.1    Chao, M.V.2
  • 6
    • 0025774207 scopus 로고
    • High-affinity NGF binding requires coexpression of the trk protooncogene and the low-affinity NGF receptor
    • Hempstead B. L., Martin-Zanca D., Kaplan D. R., Parada L. F., and Chao M. V. (1991) High-affinity NGF binding requires coexpression of the trk protooncogene and the low-affinity NGF receptor. Nature 350, 678-683.
    • (1991) Nature , vol.350 , pp. 678-683
    • Hempstead, B.L.1    Martin-Zanca, D.2    Kaplan, D.R.3    Parada, L.F.4    Chao, M.V.5
  • 7
    • 0029021457 scopus 로고
    • p75 and Trk: A two-receptor system
    • Chao M. V. and Hempstead B. L. (1995) p75 and Trk: A two-receptor system. Trends Neurosci. 18, 321-326.
    • (1995) Trends Neurosci. , vol.18 , pp. 321-326
    • Chao, M.V.1    Hempstead, B.L.2
  • 9
    • 0028270620 scopus 로고
    • The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development
    • Barrett G. L. and Bartlett P. F. (1994) The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development. Proc. Natl. Acad. Sci. USA 91, 6501-6505.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6501-6505
    • Barrett, G.L.1    Bartlett, P.F.2
  • 10
    • 16944367478 scopus 로고    scopus 로고
    • Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis
    • Majdan M., Lachance C., Gloster A., Aloyz R., Zeindler C., Bamji S., et al. (1997) Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis. J. Neurosci. 17, 6988-6998.
    • (1997) J. Neurosci. , vol.17 , pp. 6988-6998
    • Majdan, M.1    Lachance, C.2    Gloster, A.3    Aloyz, R.4    Zeindler, C.5    Bamji, S.6
  • 11
    • 0026747063 scopus 로고
    • Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
    • Lee K. F., Li E., Huber L. J., Landis S. C., Sharpe A. H., Chao M. V., et al. (1992) Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69, 737-749.
    • (1992) Cell , vol.69 , pp. 737-749
    • Lee, K.F.1    Li, E.2    Huber, L.J.3    Landis, S.C.4    Sharpe, A.H.5    Chao, M.V.6
  • 12
    • 0033591306 scopus 로고    scopus 로고
    • Differential loss of spinal sensory but not motor neurons in the p75NTR knockout mouse
    • Murray S. S., Bartlett P. F., and Cheema S. S. (1999) Differential loss of spinal sensory but not motor neurons in the p75NTR knockout mouse. Neurosci. Lett., 267, 45-48.
    • (1999) Neurosci. Lett. , vol.267 , pp. 45-48
    • Murray, S.S.1    Bartlett, P.F.2    Cheema, S.S.3
  • 13
    • 0032559622 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
    • Bamji S. X., Majdan M., Pozniak C. D., Belliveau D. J., Aloyz R., Kohn J., et al. (1998) The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J. Cell Biol. 140, 911-923.
    • (1998) J. Cell Biol. , vol.140 , pp. 911-923
    • Bamji, S.X.1    Majdan, M.2    Pozniak, C.D.3    Belliveau, D.J.4    Aloyz, R.5    Kohn, J.6
  • 14
    • 0029829495 scopus 로고    scopus 로고
    • Survival of cholinergic forebrain neurons in developing p75NGFR-deficient mice
    • Van der Zee C. E., Ross G. M., Riopelle R. J., and Hagg T. (1996) Survival of cholinergic forebrain neurons in developing p75NGFR-deficient mice. Science 274, 1729-1732.
    • (1996) Science , vol.274 , pp. 1729-1732
    • Van der Zee, C.E.1    Ross, G.M.2    Riopelle, R.J.3    Hagg, T.4
  • 15
    • 0030610047 scopus 로고    scopus 로고
    • Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation
    • Yeo T. T., Chua-Couzens J., Butcher L. L., Bredesen D. E., Cooper J. D., Valletta J. S., et al. (1997) Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. J. Neurosci. 17, 7594-7605.
    • (1997) J. Neurosci. , vol.17 , pp. 7594-7605
    • Yeo, T.T.1    Chua-Couzens, J.2    Butcher, L.L.3    Bredesen, D.E.4    Cooper, J.D.5    Valletta, J.S.6
  • 16
    • 0009513558 scopus 로고    scopus 로고
    • The role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury
    • in press
    • Coulson E. J., Reid K., Cheema S. S., and Bartlett P. F. (1999) The role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury. Clin. Exp. Pharmacol. Physiol., in press.
    • (1999) Clin. Exp. Pharmacol. Physiol.
    • Coulson, E.J.1    Reid, K.2    Cheema, S.S.3    Bartlett, P.F.4
  • 17
    • 0028868789 scopus 로고
    • Axotomy induces a different modulation of both low-affinity nerve growth factor receptor and choline acetyltransferase between adult rat spinal and brainstem motoneurons
    • Rende M., Giambanco I., Buratta M., and Tonali P. (1995) Axotomy induces a different modulation of both low-affinity nerve growth factor receptor and choline acetyltransferase between adult rat spinal and brainstem motoneurons. J. Comp. Neurol. 363, 249-263.
    • (1995) J. Comp. Neurol. , vol.363 , pp. 249-263
    • Rende, M.1    Giambanco, I.2    Buratta, M.3    Tonali, P.4
  • 18
    • 0029985954 scopus 로고    scopus 로고
    • Differential expression of the p75 nerve growth factor receptor in glia and neurons of the rat dorsal root ganglia after peripheral nerve transection
    • Zhou X. F., Rush R. A., and McLachlan E. M. (1996) Differential expression of the p75 nerve growth factor receptor in glia and neurons of the rat dorsal root ganglia after peripheral nerve transection. J. Neurosci. 16, 2901-2911.
    • (1996) J. Neurosci. , vol.16 , pp. 2901-2911
    • Zhou, X.F.1    Rush, R.A.2    McLachlan, E.M.3
  • 19
    • 0029910154 scopus 로고    scopus 로고
    • Reducing p75 nerve growth factor receptor levels using antisense oligonucleotides prevents the loss of axotomized sensory neurons in the dorsal root ganglia of newborn rats
    • Cheema S. S., Barrett G. L., and Bartlett P. F. (1996) Reducing p75 nerve growth factor receptor levels using antisense oligonucleotides prevents the loss of axotomized sensory neurons in the dorsal root ganglia of newborn rats. J. Neurosci. Res. 46, 239-245.
    • (1996) J. Neurosci. Res. , vol.46 , pp. 239-245
    • Cheema, S.S.1    Barrett, G.L.2    Bartlett, P.F.3
  • 20
    • 0031982883 scopus 로고    scopus 로고
    • Effects of facial nerve injury on mouse motoneurons lacking the p75 low-affinity neurotrophin receptor
    • Ferri C. C., Moore F. A., and Bisby M. A. (1998) Effects of facial nerve injury on mouse motoneurons lacking the p75 low-affinity neurotrophin receptor. J. Neurobiol. 34, 1-9.
    • (1998) J. Neurobiol. , vol.34 , pp. 1-9
    • Ferri, C.C.1    Moore, F.A.2    Bisby, M.A.3
  • 22
    • 0022871791 scopus 로고
    • Distribution of neuronal receptors for nerve growth factor in the rat
    • Richardson P. M., Issa V. M., and Riopelle R. J. (1986) Distribution of neuronal receptors for nerve growth factor in the rat. J. Neurosci. 6, 2312-2321.
    • (1986) J. Neurosci. , vol.6 , pp. 2312-2321
    • Richardson, P.M.1    Issa, V.M.2    Riopelle, R.J.3
  • 23
    • 0023191469 scopus 로고
    • A quantitative study of the developmental expression of nerve growth factor (NGF) receptor in rats
    • Yan Q. and Johnson E. M. Jr. (1987) A quantitative study of the developmental expression of nerve growth factor (NGF) receptor in rats. Dev. Biol. 121, 139-148.
    • (1987) Dev. Biol. , vol.121 , pp. 139-148
    • Yan, Q.1    Johnson E.M., Jr.2
  • 24
    • 84940130218 scopus 로고
    • Hippocampal p75 nerve growth factor receptor immunoreactivity in development, normal aging and senescence
    • Kerwin J. M., Morris C. M., Johnson M., Perry R. H., and Perry E. K. (1993) Hippocampal p75 nerve growth factor receptor immunoreactivity in development, normal aging and senescence. Acta Anat. 147, 216-222.
    • (1993) Acta Anat. , vol.147 , pp. 216-222
    • Kerwin, J.M.1    Morris, C.M.2    Johnson, M.3    Perry, R.H.4    Perry, E.K.5
  • 25
    • 0025950335 scopus 로고
    • Separate signals mediate hypoglossal motor neuron response to axonal injury
    • Moix L. J., Greeson D. M., Armstrong D. M., and Wiley R. G. (1991) Separate signals mediate hypoglossal motor neuron response to axonal injury. Brain Res. 564, 176-180.
    • (1991) Brain Res. , vol.564 , pp. 176-180
    • Moix, L.J.1    Greeson, D.M.2    Armstrong, D.M.3    Wiley, R.G.4
  • 26
    • 0029154564 scopus 로고
    • Expressions of nerve growth factor and p75 low affinity receptor after transient forebrain ischemia in gerbil hippocampal CA1 neurons
    • Lee T. H., Abe K., Kogure K., and Itoyama Y. (1995) Expressions of nerve growth factor and p75 low affinity receptor after transient forebrain ischemia in gerbil hippocampal CA1 neurons. J. Neurosci. Res. 41, 684-695.
    • (1995) J. Neurosci. Res. , vol.41 , pp. 684-695
    • Lee, T.H.1    Abe, K.2    Kogure, K.3    Itoyama, Y.4
  • 27
    • 0028889871 scopus 로고
    • Destruction of the cholinergic basal forebrain using immunotoxin to rat NGF receptor: Modeling the cholinergic degeneration of Alzheimer's disease
    • Wiley R. G., Berbos T. G., Deckwerth T. L., Johnson E. M. Jr., and Lappi D. A. (1995) Destruction of the cholinergic basal forebrain using immunotoxin to rat NGF receptor: Modeling the cholinergic degeneration of Alzheimer's disease. J. Neurol. Sci. 128, 157-166.
    • (1995) J. Neurol. Sci. , vol.128 , pp. 157-166
    • Wiley, R.G.1    Berbos, T.G.2    Deckwerth, T.L.3    Johnson E.M., Jr.4    Lappi, D.A.5
  • 28
    • 0029787071 scopus 로고    scopus 로고
    • Induction of cell death by endogenous nerve growth factor through its p75 receptor
    • Frade J. M., Rodriguez-Tebar A., and Barde Y. A. (1996) Induction of cell death by endogenous nerve growth factor through its p75 receptor. Nature 383, 166-168.
    • (1996) Nature , vol.383 , pp. 166-168
    • Frade, J.M.1    Rodriguez-Tebar, A.2    Barde, Y.A.3
  • 29
    • 0031934936 scopus 로고    scopus 로고
    • Microglia-derived nerve growth factor causes cell death in the developing retina
    • Frade J. M. and Barde Y. A. (1998) Microglia-derived nerve growth factor causes cell death in the developing retina. Neuron 20, 35-41.
    • (1998) Neuron , vol.20 , pp. 35-41
    • Frade, J.M.1    Barde, Y.A.2
  • 30
    • 0029805770 scopus 로고    scopus 로고
    • Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
    • Casaccia-Bonnefil P., Carter B. D., Dobrowsky R. T., and Chao M. V. (1996) Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 383, 716-719.
    • (1996) Nature , vol.383 , pp. 716-719
    • Casaccia-Bonnefil, P.1    Carter, B.D.2    Dobrowsky, R.T.3    Chao, M.V.4
  • 31
    • 13144259635 scopus 로고    scopus 로고
    • TrkB signalling inhibis p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptove neurons
    • Davey F. and Davies A. M. (1998) TrkB signalling inhibis p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptove neurons. Curr. Biol. 8, 915.
    • (1998) Curr. Biol. , vol.8 , pp. 915
    • Davey, F.1    Davies, A.M.2
  • 32
    • 0028264964 scopus 로고
    • Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos
    • von Bartheld C. S., Kinoshita Y., Prevette D., Yin Q. W., Oppenheim R. W., and Bothwell M. (1994) Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos. Neuron 12, 639-654.
    • (1994) Neuron , vol.12 , pp. 639-654
    • Von Bartheld, C.S.1    Kinoshita, Y.2    Prevette, D.3    Yin, Q.W.4    Oppenheim, R.W.5    Bothwell, M.6
  • 34
    • 0029819746 scopus 로고    scopus 로고
    • Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes
    • Cohen R. I., Marmur R., Norton W. T., Mehler M. F., and Kessler J. A. (1996) Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes. J. Neurosci. 16, 6433-6442.
    • (1996) J. Neurosci. , vol.16 , pp. 6433-6442
    • Cohen, R.I.1    Marmur, R.2    Norton, W.T.3    Mehler, M.F.4    Kessler, J.A.5
  • 35
    • 0000326996 scopus 로고    scopus 로고
    • Competitive singaling between trkA and p75 nerve growth factor receptors determines cell survival
    • Yoon S. O., Casaccia-Bonnefil P., Carter B., and Chao M. V. (1998) Competitive singaling between trkA and p75 nerve growth factor receptors determines cell survival. J. Neurosci. 18, 3273-3281.
    • (1998) J. Neurosci. , vol.18 , pp. 3273-3281
    • Yoon, S.O.1    Casaccia-Bonnefil, P.2    Carter, B.3    Chao, M.V.4
  • 36
    • 0032520192 scopus 로고    scopus 로고
    • p75 neurotrophin receptor expression on adult human oligodendrocytes: Signaling without cell death in response to NGF
    • Ladiwala U., Lachance C., Simoneau S. J., Bhakar A., Barker P. A., and Antel J. P. (1998) p75 neurotrophin receptor expression on adult human oligodendrocytes: Signaling without cell death in response to NGF. J. Neurosci. 18, 1297-1304.
    • (1998) J. Neurosci. , vol.18 , pp. 1297-1304
    • Ladiwala, U.1    Lachance, C.2    Simoneau, S.J.3    Bhakar, A.4    Barker, P.A.5    Antel, J.P.6
  • 37
    • 0029879308 scopus 로고    scopus 로고
    • TrkA activation is sufficient to rescue axotomized cholinergic neurons
    • Lucidi-Phillipi C. A., Clary D. O., Reichardt L. F., and Gage F. H. (1996) TrkA activation is sufficient to rescue axotomized cholinergic neurons. Neuron 16, 653-663.
    • (1996) Neuron , vol.16 , pp. 653-663
    • Lucidi-Phillipi, C.A.1    Clary, D.O.2    Reichardt, L.F.3    Gage, F.H.4
  • 38
    • 0028062741 scopus 로고
    • The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279
    • Barker P. A., Barbee G., Misko T. P., and Shooter E. M. (1994) The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279. J. Biol. Chem. 269, 30,645-30,650.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30645-30650
    • Barker, P.A.1    Barbee, G.2    Misko, T.P.3    Shooter, E.M.4
  • 39
    • 0030016335 scopus 로고    scopus 로고
    • p75(NGFR) and TrkA receptors collaborate to rapidly activate a p75(NGFR)-associated protein kinase
    • Canossa M., Twiss J. L., Verity A. N., and Shooter E. M. (1996) p75(NGFR) and TrkA receptors collaborate to rapidly activate a p75(NGFR)-associated protein kinase. EMBO J. 15, 3369-3376.
    • (1996) EMBO J. , vol.15 , pp. 3369-3376
    • Canossa, M.1    Twiss, J.L.2    Verity, A.N.3    Shooter, E.M.4
  • 40
    • 0033593655 scopus 로고    scopus 로고
    • Prevention of constitutive TNF receptor 1 signaling by silencer of death domains
    • Jiang Y., Woronicz J. D., Liu W., and Goeddel D. V. (1999) Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 283, 543-546.
    • (1999) Science , vol.283 , pp. 543-546
    • Jiang, Y.1    Woronicz, J.D.2    Liu, W.3    Goeddel, D.V.4
  • 41
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: Downstream AKTion blocks apoptosis
    • Franke T. F., Kaplan D. R., and Cantley L. C. (1997) PI3K: downstream AKTion blocks apoptosis. Cell 88, 435-437.
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 42
    • 0031823035 scopus 로고    scopus 로고
    • Neurotrophins: The biological paradox of survival factors eliciting apoptosis
    • Casaccia-Bonnefil P., Kong H., and Chao M. V. (1998) Neurotrophins: The biological paradox of survival factors eliciting apoptosis. Cell Death Differ. 5, 357-364.
    • (1998) Cell Death Differ. , vol.5 , pp. 357-364
    • Casaccia-Bonnefil, P.1    Kong, H.2    Chao, M.V.3
  • 43
    • 0030959304 scopus 로고    scopus 로고
    • Bcl-2 phosphorylation required for anti-apoptosis function
    • Ito T., Deng X., Carr B., and May W. S. (1997) Bcl-2 phosphorylation required for anti-apoptosis function. J. Biol. Chem. 272, 11,671-11,673.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11671-11673
    • Ito, T.1    Deng, X.2    Carr, B.3    May, W.S.4
  • 44
    • 0030789196 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis
    • Horiuchi M., Hayashida W., Kambe T., Yamada T., and Dzau V. J. (1997) Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J. Biol. Chem. 272, 19,022-19,026.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19022-19026
    • Horiuchi, M.1    Hayashida, W.2    Kambe, T.3    Yamada, T.4    Dzau, V.J.5
  • 45
    • 15644381250 scopus 로고    scopus 로고
    • Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1
    • Maundrell K., Antonsson B., Magnenat E., Camps M., Muda M., Chabert C., et al. (1997) Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1. J. Biol. Chem. 272, 25,238-25,242.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25238-25242
    • Maundrell, K.1    Antonsson, B.2    Magnenat, E.3    Camps, M.4    Muda, M.5    Chabert, C.6
  • 46
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • del Peso L., Gonzalez-Garcia M., Page C., Herrera R., and Nunez G. (1997) Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278, 687-689.
    • (1997) Science , vol.278 , pp. 687-689
    • Del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 47
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A., Bonni A., Zigmond M. J., Lin M. Z., Juo P., Hu L. S., et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6
  • 48
    • 0032508414 scopus 로고    scopus 로고
    • NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • Wang C.-Y., Mayo M. W., Korneluk R. G., Goeddel D. V., and Baldwin A. S. Jr. (1998) NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281, 1680-1683.
    • (1998) Science , vol.281 , pp. 1680-1683
    • Wang, C.-Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin A.S., Jr.5
  • 49
    • 0029886779 scopus 로고    scopus 로고
    • Nerve growth factor (NGF)-mediated protection of neural crest cells from antimitotic agent-induced apoptosis: The role of the low-affinity NGF receptor
    • Cortazzo M. H., Kassis E. S., Sproul K. A., and Schor N. F. (1996) Nerve growth factor (NGF)-mediated protection of neural crest cells from antimitotic agent-induced apoptosis: The role of the low-affinity NGF receptor. J. Neurosci. 16, 3895-3899.
    • (1996) J. Neurosci. , vol.16 , pp. 3895-3899
    • Cortazzo, M.H.1    Kassis, E.S.2    Sproul, K.A.3    Schor, N.F.4
  • 50
    • 0028985261 scopus 로고
    • Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects
    • Boldin M. P., Mett I. L., Varfolomeev E. E., Chumakov I., Shemer-Avni Y., Camonis J. H., et al. (1995) Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects. J. Biol. Chem. 270, 387-391.
    • (1995) J. Biol. Chem. , vol.270 , pp. 387-391
    • Boldin, M.P.1    Mett, I.L.2    Varfolomeev, E.E.3    Chumakov, I.4    Shemer-Avni, Y.5    Camonis, J.H.6
  • 51
    • 0032558787 scopus 로고    scopus 로고
    • The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis
    • Mehlen P., Rabizadeh S., Snipas S. J., Assa-Munt N., Salvesen G. S.., and Bredesen D. E. (1998) The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395, 801-804.
    • (1998) Nature , vol.395 , pp. 801-804
    • Mehlen, P.1    Rabizadeh, S.2    Snipas, S.J.3    Assa-Munt, N.4    Salvesen, G.S.5    Bredesen, D.E.6
  • 52
    • 0030900944 scopus 로고    scopus 로고
    • Mechanisms of apoptotic cell death
    • Rowan S. and Fisher D. E. (1997) Mechanisms of apoptotic cell death. Leukemia 11, 457-465.
    • (1997) Leukemia , vol.11 , pp. 457-465
    • Rowan, S.1    Fisher, D.E.2
  • 53
    • 0029794385 scopus 로고    scopus 로고
    • The ICE family of cysteine proteases as effectors of cell death
    • Kumar S. and Lavin M. F. (1996) The ICE family of cysteine proteases as effectors of cell death. Cell Death Differ. 3, 255-267.
    • (1996) Cell Death Differ. , vol.3 , pp. 255-267
    • Kumar, S.1    Lavin, M.F.2
  • 55
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata S. (1997) Apoptosis by death factor. Cell 88, 355-365.
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 57
    • 0030815382 scopus 로고    scopus 로고
    • An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators
    • Edwards D. N., Towb P., and Wasserman S. A. (1997) An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators. Development 124, 3855-3864.
    • (1997) Development , vol.124 , pp. 3855-3864
    • Edwards, D.N.1    Towb, P.2    Wasserman, S.A.3
  • 58
    • 0033522878 scopus 로고    scopus 로고
    • p75NTR mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-XL
    • Coulson E. J., Reid K., Barrett G. L., and Bartlett P. F. (1999) p75NTR mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-XL. J. Biol. Chem., 274, 16,387-16,391.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16387-16391
    • Coulson, E.J.1    Reid, K.2    Barrett, G.L.3    Bartlett, P.F.4
  • 59
    • 0033613831 scopus 로고    scopus 로고
    • Association of the p75NTR neurotrophin receptor with TRAF 6
    • Khursigara G., Orlinick J. R., and Chao M. V. (1999) Association of the p75NTR neurotrophin receptor with TRAF 6. J. Biol. Chem. 274, 2597-2600.
    • (1999) J. Biol. Chem. , vol.274 , pp. 2597-2600
    • Khursigara, G.1    Orlinick, J.R.2    Chao, M.V.3
  • 60
    • 0031039882 scopus 로고    scopus 로고
    • Neurotrophins live or let die: Does p75NTR decide?
    • Carter B. D. and Lewin G. R. (1997) Neurotrophins live or let die: Does p75NTR decide? Neuron 18, 187-190.
    • (1997) Neuron , vol.18 , pp. 187-190
    • Carter, B.D.1    Lewin, G.R.2
  • 61
    • 0030851905 scopus 로고    scopus 로고
    • NMR structure of the death domain of the p75 neurotrophin receptor
    • Liepinsh E., Ilag L. L., Otting G., and Ibanez C. F. (1997) NMR structure of the death domain of the p75 neurotrophin receptor. EMBO J. 16, 4999-5005.
    • (1997) EMBO J. , vol.16 , pp. 4999-5005
    • Liepinsh, E.1    Ilag, L.L.2    Otting, G.3    Ibanez, C.F.4
  • 62
    • 0031057656 scopus 로고    scopus 로고
    • Bcl-2 gene family in the nervous system
    • Merry D. E. and Korsmeyer S. J. (1997) Bcl-2 gene family in the nervous system. Annu. Rev. Neurosci. 20, 245-267.
    • (1997) Annu. Rev. Neurosci. , vol.20 , pp. 245-267
    • Merry, D.E.1    Korsmeyer, S.J.2
  • 63
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the Bcl-2 family
    • Reed J. C. (1997) Double identity for proteins of the Bcl-2 family. Nature 387, 773-776.
    • (1997) Nature , vol.387 , pp. 773-776
    • Reed, J.C.1
  • 64
    • 0030916669 scopus 로고    scopus 로고
    • The proto-oncogene Bcl-2 and its role in regulating apoptosis
    • Kroemer G. (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med. 3, 614-620.
    • (1997) Nature Med. , vol.3 , pp. 614-620
    • Kroemer, G.1
  • 66
    • 0032576692 scopus 로고    scopus 로고
    • Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
    • Rosse T., Olivier R., Monney L., Rager M., Conus S., Fellay I., et al. (1998) Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature 391, 496-499.
    • (1998) Nature , vol.391 , pp. 496-499
    • Rosse, T.1    Olivier, R.2    Monney, L.3    Rager, M.4    Conus, S.5    Fellay, I.6
  • 67
    • 0029609086 scopus 로고
    • Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    • Strasser A., Harris A. W., Huang D. C., Krammer P. H., and Cory S. (1995) Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO 14, 6136-6147.
    • (1995) EMBO , vol.14 , pp. 6136-6147
    • Strasser, A.1    Harris, A.W.2    Huang, D.C.3    Krammer, P.H.4    Cory, S.5
  • 68
    • 0029894283 scopus 로고    scopus 로고
    • Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-XL
    • Erhardt P. and Cooper G. M. (1996) Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-XL. J. Biol. Chem. 271, 17,601-17,604.
    • (1996) J. Biol. Chem. , vol.271 , Issue.17 , pp. 601-617
    • Erhardt, P.1    Cooper, G.M.2
  • 69
    • 0027320760 scopus 로고
    • A system for characterizing cellular and molecular events in programmed neuronal cell death
    • Pittman R. N., Wang S., DiBenedetto A. J., and Mills J. C. (1993) A system for characterizing cellular and molecular events in programmed neuronal cell death. J. Neurosci. 13, 3669-3680.
    • (1993) J. Neurosci. , vol.13 , pp. 3669-3680
    • Pittman, R.N.1    Wang, S.2    DiBenedetto, A.J.3    Mills, J.C.4
  • 70
    • 0029838165 scopus 로고    scopus 로고
    • Ordering the cell death pathway. Differential effects of Bcl-2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells
    • Park D. S., Stefanis L., Yan C. Y. I., Farinelli S. E., and Greene L. A. (1996) Ordering the cell death pathway. Differential effects of Bcl-2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells. J. Biol. Chem. 271, 21,898-21,905.
    • (1996) J. Biol. Chem. , vol.271 , pp. 21898-21905
    • Park, D.S.1    Stefanis, L.2    Yan, C.Y.I.3    Farinelli, S.E.4    Greene, L.A.5
  • 72
    • 0028922885 scopus 로고
    • Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
    • Motoyama N., Wang F., Roth K. A., Sawa H., Nakayama K., Nakayama K., et al. (1995) Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267, 1506-1510.
    • (1995) Science , vol.267 , pp. 1506-1510
    • Motoyama, N.1    Wang, F.2    Roth, K.A.3    Sawa, H.4    Nakayama, K.5    Nakayama, K.6
  • 73
    • 0030898680 scopus 로고    scopus 로고
    • Bax deficiency prevents the increased cell death of immature neurons in Bcl-x-deficient mice
    • Shindler K. S., Latham C. B., and Roth K. A. (1997) Bax deficiency prevents the increased cell death of immature neurons in Bcl-x-deficient mice. J. Neurosci. 17, 3112-3119.
    • (1997) J. Neurosci. , vol.17 , pp. 3112-3119
    • Shindler, K.S.1    Latham, C.B.2    Roth, K.A.3
  • 74
    • 0027527099 scopus 로고
    • Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice
    • Nakayama K., Negishi I., Kuida K., Shinkai Y., Louie M. C., Fields L. E., et al. (1993) Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261, 1584-1588.
    • (1993) Science , vol.261 , pp. 1584-1588
    • Nakayama, K.1    Negishi, I.2    Kuida, K.3    Shinkai, Y.4    Louie, M.C.5    Fields, L.E.6
  • 75
    • 0027427492 scopus 로고
    • Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
    • Veis D. J., Sorenson C. M., Shutter J. R., and Korsmeyer S. J. (1993) Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75, 229-240.
    • (1993) Cell , vol.75 , pp. 229-240
    • Veis, D.J.1    Sorenson, C.M.2    Shutter, J.R.3    Korsmeyer, S.J.4
  • 76
    • 0028178385 scopus 로고
    • Bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS
    • Merry D. E., Veis D. J., Hickey W. F., and Korsmeyer S. J. (1994) Bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development 120, 301-311.
    • (1994) Development , vol.120 , pp. 301-311
    • Merry, D.E.1    Veis, D.J.2    Hickey, W.F.3    Korsmeyer, S.J.4
  • 77
    • 1842339274 scopus 로고    scopus 로고
    • Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development
    • Pinon L. G., Middleton G., and Davies A. M. (1997) Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development. Development 124, 4173-4178.
    • (1997) Development , vol.124 , pp. 4173-4178
    • Pinon, L.G.1    Middleton, G.2    Davies, A.M.3
  • 78
    • 0027243086 scopus 로고
    • The proto-oncogene Bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
    • Allsopp T. E., Wyatt S., Paterson H. F., and Davies A. M. (1993) The proto-oncogene Bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73, 295-307.
    • (1993) Cell , vol.73 , pp. 295-307
    • Allsopp, T.E.1    Wyatt, S.2    Paterson, H.F.3    Davies, A.M.4
  • 79
    • 0029056049 scopus 로고
    • Role of Bcl-2 in the brain-derived neurotrophic factor survival response
    • Allsopp T. E., Kiselev S., Wyatt S., and Davies A. M. (1995) Role of Bcl-2 in the brain-derived neurotrophic factor survival response. Eur. J. Neurosci. 7, 1266-1272.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1266-1272
    • Allsopp, T.E.1    Kiselev, S.2    Wyatt, S.3    Davies, A.M.4
  • 80
    • 0029949082 scopus 로고    scopus 로고
    • Bcl-2 over-expression reduces apoptotic photoreceptor cell death in three different retinal degenerations
    • Chen J., Flannery J. G., LaVail M. M., Steinberg R. H., Xu J., and Simon M. I. (1996) Bcl-2 over-expression reduces apoptotic photoreceptor cell death in three different retinal degenerations. Proc. Natl. Acad. Sci. USA 93, 7042-7047.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7042-7047
    • Chen, J.1    Flannery, J.G.2    LaVail, M.M.3    Steinberg, R.H.4    Xu, J.5    Simon, M.I.6
  • 81
    • 0029047946 scopus 로고
    • Bcl-2 transgene expression can protect neurons against developmental and induced cell death
    • Farlie P. G., Dringen R., Rees S. M., Kannourakis G., and Bernard O. (1995) Bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc. Natl. Acad. Sci. USA 92, 4397-4401.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4397-4401
    • Farlie, P.G.1    Dringen, R.2    Rees, S.M.3    Kannourakis, G.4    Bernard, O.5
  • 82
    • 0029814736 scopus 로고    scopus 로고
    • Bcl-2 sensitivity differentiates two pathways for motoneuronal death in the wobbler mutant mouse
    • Coulpier M., Junier M. P., Peschanski M., and Dreyfus P. A. (1996) Bcl-2 sensitivity differentiates two pathways for motoneuronal death in the wobbler mutant mouse. J. Neurosci. 16, 5897-5904.
    • (1996) J. Neurosci. , vol.16 , pp. 5897-5904
    • Coulpier, M.1    Junier, M.P.2    Peschanski, M.3    Dreyfus, P.A.4
  • 83
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • Reed J. C. (1994) Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124, 1-6.
    • (1994) J. Cell Biol. , vol.124 , pp. 1-6
    • Reed, J.C.1
  • 84
    • 0032504253 scopus 로고    scopus 로고
    • A potent cell death activity associated with transient high level expression of Bcl-2
    • Uhlmann E. J., Subramanian T., Vater C. A., Lutz R., and Chinnadurai G. (1998) A potent cell death activity associated with transient high level expression of Bcl-2. J. Biol. Chem. 273, 17,926-17,932.
    • (1998) J. Biol. Chem. , vol.273 , pp. 17926-17932
    • Uhlmann, E.J.1    Subramanian, T.2    Vater, C.A.3    Lutz, R.4    Chinnadurai, G.5
  • 86
    • 0030298294 scopus 로고    scopus 로고
    • Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
    • Liu Z. G., Hsu H., Goeddel D. V., and Karin M. (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87, 565-576.
    • (1996) Cell , vol.87 , pp. 565-576
    • Liu, Z.G.1    Hsu, H.2    Goeddel, D.V.3    Karin, M.4
  • 87
    • 0030907935 scopus 로고    scopus 로고
    • NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
    • Su Y. C., Han J., Xu S., Cobb M., and Skolnik E. Y. (1997) NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 16, 1279-1290.
    • (1997) EMBO J. , vol.16 , pp. 1279-1290
    • Su, Y.C.1    Han, J.2    Xu, S.3    Cobb, M.4    Skolnik, E.Y.5
  • 88
    • 0031048067 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2
    • Reinhard C., Shamoon B., Shyamala V., and Williams L. T. (1997) Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J. 16, 1080-1092.
    • (1997) EMBO J. , vol.16 , pp. 1080-1092
    • Reinhard, C.1    Shamoon, B.2    Shyamala, V.3    Williams, L.T.4
  • 89
    • 0030780804 scopus 로고    scopus 로고
    • Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
    • Yang D. D., Kuan C. Y., Whitmarsh A. J., Rincon M., Zheng T. S., Davis R. J., Rakic P., et al. (1997) Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389, 865-870.
    • (1997) Nature , vol.389 , pp. 865-870
    • Yang, D.D.1    Kuan, C.Y.2    Whitmarsh, A.J.3    Rincon, M.4    Zheng, T.S.5    Davis, R.J.6    Rakic, P.7
  • 90
    • 0031587883 scopus 로고    scopus 로고
    • Daxx, a novel Fas-binding protein that activates JNK and apoptosis
    • Yang X., Khosravi-Far R., Chang H. Y., and Baltimore D. (1997) Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89, 1067-1076.
    • (1997) Cell , vol.89 , pp. 1067-1076
    • Yang, X.1    Khosravi-Far, R.2    Chang, H.Y.3    Baltimore, D.4
  • 92
    • 17344374130 scopus 로고    scopus 로고
    • Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway
    • Maroney A. C., Glicksman M. A., Basma A. N., Walton K. M., Knight E. Jr., Murphy C. A., et al. (1998) Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J. Neurosci. 18, 104-111.
    • (1998) J. Neurosci. , vol.18 , pp. 104-111
    • Maroney, A.C.1    Glicksman, M.A.2    Basma, A.N.3    Walton, K.M.4    Knight E., Jr.5    Murphy, C.A.6
  • 93
    • 0030458720 scopus 로고    scopus 로고
    • Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases
    • Deshmukh M., Vasilakos J., Deckwerth T. L., Lampe P. A., Shivers B. D., and Johnson E. M. Jr. (1996) Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. J. Cell Biol. 135, 1341-1354.
    • (1996) J. Cell Biol. , vol.135 , pp. 1341-1354
    • Deshmukh, M.1    Vasilakos, J.2    Deckwerth, T.L.3    Lampe, P.A.4    Shivers, B.D.5    Johnson E.M., Jr.6
  • 94
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., Dickens M., Raingeaud J., Davis R. J., and Greenberg M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 96
    • 0031025302 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappa B (NFkappaB) activity induces nerve growth factor-resistant apoptosis in PC12 cells
    • Taglialatela G., Robinson R., and Perez-Polo J. R. (1997) Inhibition of nuclear factor kappa B (NFkappaB) activity induces nerve growth factor-resistant apoptosis in PC12 cells. J. Neurosci. Res. 47, 155-162.
    • (1997) J. Neurosci. Res. , vol.47 , pp. 155-162
    • Taglialatela, G.1    Robinson, R.2    Perez-Polo, J.R.3
  • 98
    • 0028285049 scopus 로고
    • Nerve growth factor and its low-affinity receptor promote Schwann cell migration
    • Anton E. S., Weskamp G., Reichardt L. F., and Matthew W. D. (1994) Nerve growth factor and its low-affinity receptor promote Schwann cell migration. Proc. Natl. Acad. Sci. USA 91, 2795-2799.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2795-2799
    • Anton, E.S.1    Weskamp, G.2    Reichardt, L.F.3    Matthew, W.D.4
  • 99
    • 0029007640 scopus 로고
    • Ceramide: An endogenous regulator of apoptosis and growth suppression
    • Pushkareva M., Obeid L. M., and Hannun Y. A. (1995) Ceramide: An endogenous regulator of apoptosis and growth suppression. Immunol. Today 16, 294-297.
    • (1995) Immunol. Today , vol.16 , pp. 294-297
    • Pushkareva, M.1    Obeid, L.M.2    Hannun, Y.A.3
  • 100
    • 0029023368 scopus 로고
    • Does endotoxin stimulate cells by mimicking ceramide?
    • Wright S. D. and Kolesnick R. N. (1995) Does endotoxin stimulate cells by mimicking ceramide? Immunol. Today 16, 297-302.
    • (1995) Immunol. Today , vol.16 , pp. 297-302
    • Wright, S.D.1    Kolesnick, R.N.2
  • 101
    • 0030595340 scopus 로고    scopus 로고
    • FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase
    • Adam-Klages S., Adam D., Wiegmann K., Struve S., Kolanus W., Schneider-Mergener J., et al. (1996) FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell 86, 937-947.
    • (1996) Cell , vol.86 , pp. 937-947
    • Adam-Klages, S.1    Adam, D.2    Wiegmann, K.3    Struve, S.4    Kolanus, W.5    Schneider-Mergener, J.6
  • 102
    • 0028108788 scopus 로고
    • Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor
    • Dobrowsky R. T., Werner M. H., Castellino A. M., Chao M. V., and Hannun Y. A. (1994) Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265, 1596-1599.
    • (1994) Science , vol.265 , pp. 1596-1599
    • Dobrowsky, R.T.1    Werner, M.H.2    Castellino, A.M.3    Chao, M.V.4    Hannun, Y.A.5
  • 103
    • 0029090337 scopus 로고
    • Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors
    • Dobrowsky R. T., Jenkins G. M., and Hannun Y. A. (1995) Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J. Biol. Chem. 270, 22,135-22,142.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13522-22142
    • Dobrowsky, R.T.1    Jenkins, G.M.2    Hannun, Y.A.3
  • 105
    • 0029092507 scopus 로고
    • Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro
    • Milligan C. E., Prevette D., Yaginuma H., Homma S., Cardwell C., Fritz L. C., et al. (1995) Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro. Neuron 15, 385-393.
    • (1995) Neuron , vol.15 , pp. 385-393
    • Milligan, C.E.1    Prevette, D.2    Yaginuma, H.3    Homma, S.4    Cardwell, C.5    Fritz, L.C.6
  • 107
    • 16944363021 scopus 로고    scopus 로고
    • Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis
    • Armstrong R. C., Aja T. J., Hoang K. D., Gaur S., Bai X., Alnemri E. S., et al. (1997) Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis. J. Neurosci. 17, 553-562.
    • (1997) J. Neurosci. , vol.17 , pp. 553-562
    • Armstrong, R.C.1    Aja, T.J.2    Hoang, K.D.3    Gaur, S.4    Bai, X.5    Alnemri, E.S.6
  • 108
    • 0031018396 scopus 로고    scopus 로고
    • Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells
    • Troy C. M., Stefanis L., Greene L. A., and Shelanski M. L. (1997) Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells. J. Neurosci. 17, 1911-1918.
    • (1997) J. Neurosci. , vol.17 , pp. 1911-1918
    • Troy, C.M.1    Stefanis, L.2    Greene, L.A.3    Shelanski, M.L.4
  • 110
    • 0029956641 scopus 로고    scopus 로고
    • Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
    • Kuida K., Zheng T. S., Na S., Kuan C., Yang D., Karasuyama H., et al. (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368-372.
    • (1996) Nature , vol.384 , pp. 368-372
    • Kuida, K.1    Zheng, T.S.2    Na, S.3    Kuan, C.4    Yang, D.5    Karasuyama, H.6
  • 111
    • 0032493870 scopus 로고    scopus 로고
    • Differential requirement for caspase 9 in apoptotic pathways in vivo
    • Hakem R., Hakem A., Duncan G. S., Henderson J. T., Woo M., Soengas M. S., et al. (1998) Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94, 339-352.
    • (1998) Cell , vol.94 , pp. 339-352
    • Hakem, R.1    Hakem, A.2    Duncan, G.S.3    Henderson, J.T.4    Woo, M.5    Soengas, M.S.6
  • 112
    • 0032493910 scopus 로고    scopus 로고
    • Reduced Apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
    • Kuida K., Haydar T. F., Kuan C.-Y., Gu Y., Taya C., Karasuyama H., et al. (1998) Reduced Apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94, 325-337.
    • (1998) Cell , vol.94 , pp. 325-337
    • Kuida, K.1    Haydar, T.F.2    Kuan, C.-Y.3    Gu, Y.4    Taya, C.5    Karasuyama, H.6
  • 113
    • 0032544564 scopus 로고    scopus 로고
    • Apaf1 is required for mitochondrial pathways of apoptosis and brain development
    • Yoshida H., Kong Y. Y., Yoshida R., Elia A. J., Hakem A., Hakem R., et al. (1998) Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94, 739-750.
    • (1998) Cell , vol.94 , pp. 739-750
    • Yoshida, H.1    Kong, Y.Y.2    Yoshida, R.3    Elia, A.J.4    Hakem, A.5    Hakem, R.6
  • 114
    • 0032489390 scopus 로고    scopus 로고
    • Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
    • Pan G., O'Rourke K., and Dixit V. M. (1998) Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J. Biol. Chem. 273, 5841-5845.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5841-5845
    • Pan, G.1    O'Rourke, K.2    Dixit, V.M.3
  • 115
    • 0030458602 scopus 로고    scopus 로고
    • A role for Jun-N-terminal kinase in anoikis; suppression by Bcl-2 and crmA
    • Frisch S. M., Vuori K., Kelaita D., and Sicks S. (1996) A role for Jun-N-terminal kinase in anoikis; suppression by Bcl-2 and crmA. J. Cell Biol. 135, 1377-1382.
    • (1996) J. Cell Biol. , vol.135 , pp. 1377-1382
    • Frisch, S.M.1    Vuori, K.2    Kelaita, D.3    Sicks, S.4
  • 117
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P., Nijhawan D., Budihardjo I., Srinivasula S. M., Ahmad M., Alnemri E. S., et al. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.