Co-infection of acyclovir-resistant and acyclovir-sensitive Herpes simplex type 2 virus strains in BS-C-1 cells

Intervirology

Volumn 42, Issue 4, 1999, Pages 247-251

  Keywan, Kazem ^a   Katz, Ehud ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

Acyclovir; Acyclovir resistance; Co infection; Herpes simplex

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HOST CELL; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; VIROGENESIS; VIRUS MUTANT;

ACYCLOVIR; ANTIVIRAL AGENTS; CELL LINE; DRUG RESISTANCE, MICROBIAL; HERPESVIRUS 2, HUMAN; HUMANS; MUTATION; PLAQUE ASSAY; VIRAL INTERFERENCE;

ANIMALIA; DNA VIRUSES; HERPES; HERPES SIMPLEX TYPE 2 VIRUS; HUMAN HERPESVIRUS 2;

EID: 0032736433     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024984     Document Type: Article

References (16)

1. Elion GB, Furman PA, Fyfe JA, de Miranda P, Beauchamp L, Schaeffer HJ: Selectivity of action of an antiherpetic agent 9-(2-hydroxyethoxymethyl)guanine. Proc Natl Acad Sci USA 1977;74:5716-5720.
2. Schaetfer HJ, Beauchamp L, de Miranda P, Elion GB, Bauer DJ, Collins P: 9-(2-hydroxyethoxymethyl)guanine activity against viruses of the herpes group. Nature 1978;272:583-585.
3. Whitley RJ, Gnann JW: Acyclovir: A decade later. N Engl J Med 1992;327:782-789.
4. Katz E, Margalith E: Characterization of a herpes simplex virus type 2 mutant, which is resistant to acycloguanosine and causes fusion of BS-C-1 cells. Arch Virol 1982;74:111-123.
5. Field HJ: Development of clinical resistance to acyclovir in herpes simplex virus-infected mice receiving oral therapy. Antimicrob Agents Chemother 1982;21:744-752.
6. Field HJ, Lay E: Characterization of latent infections in mice inoculated with herpes simplex virus which is clinically resistant to acyclovir. Antiviral Res 1984;4:43-52.
7. Ellis MN, Waters R, Hill EL, Lobe DC, Selleseth DW, Barry DW: Orofacial infection of athymic mice with defined mixtures of acyclovir-susceptible and acyclovir-resistant herpes simplex virus type 1. Antimicrob Agents Chemother 1989;33:304-310.
8. Fyfe JA, Keller PM, Furmann PA, Miller RL, Elion GB: Thymidine-kinase gene from herpes simplex virus phosphorylates the new antiviral compound 9-(2-hydroxyethoxymethyl)guanine. J Biol Chem 1978;253:8721-8727.
9. Miller WH, Miller RL: Phosphorylation of acyclovir monophosphate by GMP kinase. J Biol Chem 1980;255:7204-7207.
10. Miller WH, Miller RL: Phosphorylation of acyclovir diphosphate by cellular enzymes. Biochem Pharmacol 1982;31:3879-3884.
11. Furman PA, St. Clair MH, Fyfe JA, Rideout JL, Keller PM, Elion GB: Inhibition of herpes simplex virus induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. J Virol 1979;32:72-77.
12. Everett RD, Fenwick ML: Comparative DNA sequence analysis of the host shutoff genes of different strains of herpes simplex virus: Type 2 strain HG52 encodes a truncated UL41 product. J Gen Virol 1990;71:1387-1390.
13. Read GS, Karr BM, Knight K: Isolation of herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs gene. J Virol 1993;67:7149-7160.
14. Fenwick ML, Everett RD: Inactivation of the shutoff gene (UL41) of herpes simplex virus types 1 and 2. J Gen Virol 1990;71:2961-2967.
15. Matis J, Krivjanska M: Specific binding of herpes simplex virus type 1 (HSV-1) strain HSZP to host cell surface can provoke interference with early shutoff of host protein synthesis induced by HSV-1 strain KOS. J Gen Virol 1994;75:2053-2058.
16. Hill TM, Sadler JR, Betz JL: Virion component of herpes simplex virus type 1 KOS interferes with early shutoff of host protein synthesis induced by herpes simplex virus type 2 186. J Virol 1985;56:312-316.