Synthesis and anti-platelet aggregation, anti-inflammatory and anti- allergic activities of isoflavone quinone, isoflavanquinone and related compounds

Chinese Pharmaceutical Journal

Volumn 51, Issue 4, 1999, Pages 255-269

  Fwu, Shyang Yuan ^a   Chang, Chiung Yun ^a   Huang, Li Jiau ^a   Teng, Che Ming ^b   Wang, Jih Pyang ^a,c   Chen, Sheng Chih ^a   Kuo, Sheng Chu ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Anti allergic activity; Anti inflammatory; Anti platelet aggregation; Isoflavanquinone; Isoflavone quinone

Indexed keywords

2' HYDROXYISOFLAVAN; 2' HYDROXYISOFLAVONE; ANTIINFLAMMATORY AGENT; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; BETA GLUCURONIDASE; COLLAGEN; HISTAMINE; ISOFLAVANQUINONE; ISOFLAVONE DERIVATIVE; ISOFLAVONE QUINONE; LYSOZYME; QUINONE DERIVATIVE; SUPEROXIDE; THROMBIN; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SYNTHESIS; ENZYME RELEASE; MAST CELL DEGRANULATION; NEUTROPHIL; NONHUMAN; RAT; THROMBOCYTE AGGREGATION INHIBITION;

EID: 0032735451     PISSN: 10161015     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Kuo, S. C.; Chen, S. C.; Chen, L, H.; Wu, J. B.; Wang J. P.; Teng, C. M. Potent anti-platelet, Anti-inflammatory and Anti-allergic Isoflavanquinones from the Roots of Abrus precatorius. Planta Med. 1995, 61, 307-312.
2. Wang, J. P.; Hsu, M. F.; Chang, L. C. Kuo, J. S.; Kuo, S. C. Inhibition of Plasma Extravasation by Abruquinone A, A Natural Isoflavanquinone Isolated from Abrus Precatorius. Eur J. Pharmacol. 1995, 273, 73-81.
3. Farkas, L.; Gottsegen, A.; Nógrádi M. Synthesis of Sophorol, Violanone, Lonchocarpan, Claussequinone, Philenopteran, Leiocalycin, and Some Other Natural Isoflavonoids by the Oxidative Rearrangement of Chalcones with Thallium (III) Nitrate. J. Chem. Soc. Perkin Trans. I 1974, 2, 305-312.
4. Lupi, A.; Marta, M.; Lintas, G.; Marini Bettolo, G. B. Synthesis of Natural Isoflavanquinones by the Oxidative Rearrangement of Chalcones with Thallium (III) Nitrate: Abruquinones A and B. Gazz. Chim. Ital. 1980,110, 625-628.
5. O'Brien, J. R. Platelet Aggregation II, Some Results from a New Method of Study. J. Clin. Pathol. 1962, 15, 452-455.
6. Teng, C. M.; Chen, W. Y.; Ko, W. C.; Ouyang, C. Anti-platelet Effect of Butylidenephalide. Biochem. Biophys. Acta. 1987, 924, 375-382.
7. Boyum, A. Isolation of Mononuclear Cells and Granulocytes from Blood. Scand. J. Clin. Invest. 1968, 97 Suppl., 77-89.
8. Barret, J. P. In Lysosomes, A Laboratory Handbook; Dingle, J. T., Ed.; Elsevier/North-Holland: Amsterdam, 1972; pp 118-120.
9. Absolom, D. R. Basic Methods for the Study of Phagocytosis. Methods Enzymol. 1986, 132, 95-179.
10. Cohen, H. J.; Chovaniec, M. E. Superoxide Production by Digitonin-stimulated Guinea Pig Glycolytic and Mitochondria Inhibitors on the Activation of the Superoxide Generating System. J. Clin. Invest. 1978, 61, 1088-1096.
11. - Production by Human Neutrophils. The Preparation and Assay of NADPH Oxidase-containing Particles from Human Neutrophils. Methods Enzymol. 1984, 105, 358-365.
12. 2 receptor Antagonist, is Due to Mast Cell Degranulation. Eur. J. Pharmacol. 1989, 161, 143-150.
13. Hâkanson, R.; Rönnberg, A. L. Improved Fluorometric Assay of Histamine. Anal. Biochem. 1974, 60, 560-567.