Multinucleated giant cell formation by microglia: Induction by interleukin (IL)-4 and IL-13

Brain Research

Volumn 849, Issue 1-2, 1999, Pages 239-243

  Suzumura, Akio ^a   Tamaru, Tsukasa ^a   Yoshikawa, Minka ^a   Takayanagi, Tetsuya ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Cytokine; IL 13; IL 4; Microglia; Multinucleated giant cell

Indexed keywords

ANTIBODY; COLONY STIMULATING FACTOR; COLONY STIMULATING FACTOR 1; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GIANT CELL; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CELLS, CULTURED; COLONY-STIMULATING FACTORS; GIANT CELLS; INTERLEUKIN-13; INTERLEUKIN-4; MICE; MICE, INBRED C57BL; MICROGLIA; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032735238     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)02164-2     Document Type: Article

References (21)

1. Amano H., Yamada S., Felix R. Conony-stimulating factor-1 stimulates the fusion process in osteoclasts. J. Bone Miner. Res. 13:1998;846-853.
2. DeFife K.M., McNally J.C.R., Coltonm E., Anderson J.M. Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression. J. Immunol. 158:1997;3385-3390.
3. Fairs S., Burgio V.L., Silbestri M., Capobianchi M.R., Pacchiarotti A., Pallone F. Multinucleated giant cell generation induced by interferon gamma. Changes in the expression and distribution of the intercellular adhesion molecule-1. Lab. Invest. 71:1994;737-744.
4. Fairs S., Pallone F. Inability of normal human intestinal macrophages to form multinucleated giant cells in response to cytokines. Gut. 37:1995;798-801.
5. Gallo P., De Rossi A., Sivieri S., Chieco-Bianchi L., Tavolato B. M-CSF production by HIV-1-infected monocytes and its intrathecal synthesis. Implications for neurological HIV-1-related disease. J. Neuroimmunol. 51:1994;193-198.
6. Hernandez L.D., Foffman L.R., Wolfsberg T.G., White J.M. Virus-cell and cell-cell fusion. Annu. Rev. Cell Dev. Biol. 12:1996;627-661.
7. Jazin E.E., Soderstrom S., Ebenda T., Larhammar D. Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor. J. Neuroimmunol. 79:1997;148-154.
8. Lee T.T., Martin F.C., Merrill J.E. Lymphokine induction of rat microglia multinucleated giant cell formation. Glia. 8:1993;51-61.
9. Lemaire I., Yang H., Lafont V., Dornand J., Commes T., Cantin M.-F. Differential effects of macrophage- and granulocyte-macrophage colony-stimulating factor on cytokine gene expression during rat alveolar macrophage differentiation into multinucleated giant cells. Role for IL-6 in type 2 MGC formation. J. Immunol. 157:1996;5118-5125.
10. McNally A.K., DeFife K.M., Anderson J.M. Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity. Am. J. Pathol. 149:1996;975-985.
11. Most J., Neumayer H.P., Dierich M.P. Cytokine-induced generation of multinucleated giant cells in vitro require interferon-γ and expression of LFA-1. Eur. J. Immunol. 20:1990;1661-1667.
12. Most J., Spotl L., Gasser A., Sarti A., Dierich M.P. Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation. Blood. 89:1997;662-671.
13. Murch A.R., Grounds M.D., Marchall C.A., Papadimitriou J.M. Direct evidence that inflammatory multinucleated giant cell form by fusion. J. Pathol. 137:1981;17-23.
14. Peterson P.K., Gekker G., Hu S., Anderson W.R., Teichert M., Chao C.C., Molitor T.W. Multinucleated giant cell formation of swine microglia induced by Mycobacterium bovis. J. Infect. Dis. 173:1996;1194-1201.
15. Saginario C., Qian H.-Y., Vignery A. Identificaiton of an inducible surface molecule specific to fusing macrophage. Proc. Natl. Acad. Sci. U. S. A. 92:1995;12210-12214.
16. Suzumura A., Mezitis S.G.E., Gonatus N., Silberberg D.H. MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by gamma-interferon. J. Neuroimmunol. 15:1987;263-278.
17. Suzumura A., Sawada M., Itoh Y., Marunouchi T. Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression. J. Neuroimmunol. 53:1994;209-218.
18. Suzumura A., Sawada M., Makino M., Takayanagi T. Propentofylline inhibits production of TNFα and infection of LP-BM5 murine leukemia virus in glial cells. J. Neurovirol. 4:1998;553-559.
19. White J.M. Viral and cellular membrane fusion proteins. Annu. Rev. Physiol. 52:1990;675-697.
20. White J.M. Membrane fusion. Science. 258:1992;917-924.
21. Wong M.L., Bongiorno P.B., Rettori V., McCann S.M., Licinio J. Interleukin (IL) 1beta, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervos system and anterior pituitary during systemic inflammation: pathophysiological implications. Proc. Natl. Acad. Sci. U. S. A. 94:1997;227-232.