Commentary on PBT-1 study of high-dose consolidation versus standard therapy in metastatic breast cancer

Journal of Clinical Oncology

Volumn 17, Issue 11 SUPPL., 1999, Pages 22-24

  Livingston, Robert ^a   Crowley, John ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; FLUOROURACIL; METHOTREXATE;

AUTOLOGOUS BONE MARROW TRANSPLANTATION; BREAST CANCER; CANCER CHEMOTHERAPY; CONFERENCE PAPER; DRUG MEGADOSE; DRUG RESPONSE; HUMAN; METASTASIS; PRIORITY JOURNAL;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; DISEASE-FREE SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUOROURACIL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; METHOTREXATE; NEOPLASM METASTASIS; RANDOMIZED CONTROLLED TRIALS; SOUTH AFRICA; TIME FACTORS; UNITED STATES;

EID: 0032734816     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (5)

1. Stadtmauer EA, O'Neill A, Goldstein LJ, et al: Phase III randomized trial of high-dose chemotherapy (HDC) and stem cell support (SCT) shows no difference in overall survival or severe toxicity compared to maintenance chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) for women with metastatic breast cancer who are responding to conventional induction chemotherapy: The 'Philadelphia' Intergroup Study (PBT-1). Proc Am Soc Clin Oncol 18:1a. 1999 (abstr 1)
2. Greenberg PA, Hortobagyi GN, Smith TL, et al: Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer. J Clin Oncol 14:2197-2205, 1996
3. Falkson G, Gelman RS, Pandya KJ, et al: Eastern Cooperative Oncology Group randomized trials of observation versus maintenance therapy for patients with metastatic breast cancer in complete remission following induction treatment. J Clin Oncol 16:1669-1676, 1998
4. Antman KH, Bowlings PA, Vaughan WP, et al: High-dose chemotherapy with autologous stem-cell support for breast cancer in North America. J Clin Oncol 15:1870-1879, 1997
5. Bezwoda WR, Seymour L, Dansey RD: High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: A randomized trial. J Clin Oncol 13:2483-2489, 1995