Comparative biophysical analysis of the interaction of bronchodilating β2-adrenoceptor agonists with lipid membranes

European Journal of Medicinal Chemistry

Volumn 34, Issue 6, 1999, Pages 451-462

  Ochsner, Martin ^a   Jaekel, Klaus ^b   Mutz, Michael ^b   Anderson, Gary P ^c   John, Edgar ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Lipid membrane; Membrane microviscosity; N octanol; Thermodynamics of drug membrane interactions; Water partition coefficients; Water partition constants; 2 adrenoceptor agonists

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; FORMOTEROL; MEMBRANE LIPID; PROTEIN; SALMETEROL;

ANIMAL CELL; ARTICLE; BRONCHODILATATION; CELL MEMBRANE; CONTROLLED STUDY; DIFFUSION; DRUG ACCUMULATION; DRUG POTENCY; DRUG PROTEIN BINDING; EXTRACELLULAR SPACE; LIPID BILAYER; LIPID MEMBRANE; LIPOPHILICITY; NONHUMAN; RAT; SMOOTH MUSCLE; THERMODYNAMICS; VISCOSITY;

EID: 0032734710     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80095-6     Document Type: Article

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