Night blindness precipitated by isotretinoin in the setting of hypovitaminosis A

Australasian Journal of Dermatology

Volumn 40, Issue 4, 1999, Pages 208-210

  Welsh, Belinda M ^a   Smith, Arnold L ^b   Elder, James E ^b   Varigos, George A ^b  

^a ST VINCENT S HOSPITAL   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

13 cis retinoic acid; Cystic fibrosis; Electroretinogram; Retina; Retinoids; Vitamin A

Indexed keywords

BENZOYL PEROXIDE; CIPROFLOXACIN; CISAPRIDE; COTRIMOXAZOLE; ISOTRETINOIN; MINOCYCLINE; MISOPROSTOL; PANCRELIPASE; PREDNISOLONE; RETINOIC ACID; RETINOL;

ACNE CYSTICA; ADOLESCENT; ARTICLE; CASE REPORT; CYSTIC FIBROSIS; ELECTRORETINOGRAPHY; HUMAN; LIVER CIRRHOSIS; MALE; NIGHT BLINDNESS; RETINOL DEFICIENCY; VITAMIN SUPPLEMENTATION;

EID: 0032734465     PISSN: 00048380     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-0960.1999.00363.x     Document Type: Article

References (17)

1. 1. Carr RC. Vitamin A deficiency. In: Heckenlively JR, Arden GB (eds). Principles and Practice of Clinical Electrophysiology of Vision. St Louis: Mosby, 1991; 737-40.
2. 2. Weleber RG, Denman ST, Hanifin FM, Cunningham WJ. Abnormal retinal function associated with isotretinoin therapy for acne. Arch. Ophthalmol. 1986; 104: 831-7.
3. 3. Maclean H, Wright M, Choi D, Tidman MJ. Abnormal night vision with isotretinoin therapy for acne. Clin. Exp. Dermatol. 1995; 20: 86.
4. 4. Law WC, Rando RR. The molecular basis of retinoic acid induced night blindness. Biochem. Biophys. Res. Comm. 1989; 161: 825-9.
5. 5. Rayner RJ, Tyrrell JC, Hiller EJ et al. Night blindness and conjunctival xerosis caused by vitamin A deficiency in patients with cystic fibrosis. Arch. Dis. Child. 1989; 64: 1151-6.
6. 6. Kopel FB. Gastrointestinal manifestations of cystic fibrosis. Gastroenterology 1972; 62: 483-91.
7. 7. Congden PJ, Bruce G, Rothburn MM et al. Vitamin status in treated patients with cystic fibrosis. Arch. Dis. Child. 1981; 56: 708-14.
8. 8. Smith FR, Underwood BA, Denning CR, Varma A, Goodman DS. Depressed plasma retinol-binding protein levels in cystic fibrosis. J. Lab. Clin. Med. 1972; 80: 423-33.
9. 9. MacLusky I, Levison H. Cystic fibrosis. In: Chernick V, Boat TF (eds). Kendig's: Disorders of the Respiratory Tract in Children. Philadelphia: WB Saunders, 1998; 838-82.
10. 10. Lindblad A, Diczfalusy U, Hulterantz R, Thorell A, Strandvik B. Vitamin A concentration in the liver decreases with age in patients with cystic fibrosis. J. Pediatr. Gastroenterol. Nutr. 1997; 24: 264-70.
11. 11. Kelleher J. Laboratory measurement of nutrition in cystic fibrosis. J. R. Soc. Med. 1987; 80: S25.
12. 12. Peters SA, Rolles J. Vitamin therapy in cystic fibrosis. J. Clin. Pharm. Ther. 1993; 18: 33.
13. 13. Underwood BA, Denning CR. Blood and liver concentrations of vitamins A and E in children with cystic fibrosis. Pediatr. Res. 1972; 6: 26-31.
14. 14. Ehmann CW, Cheripko JA. Retinoids: An update. In: Drill VA, Lazar P (eds). Cutaneous Toxicity. New York: Raven Press, 1984; 239-51.
15. 15. Fraunfelder FT, LaBraieo JM, Meyer SM. Adverse ocular reactions possibly associated with isotretinoin. Am. J. Ophthalmol. 1985; 100: 534-7.
16. 16. Dew SE, Wardlaw SA, Ong DE. Effects of pharmacological retinoids on several vitamin A metabolizing enzymes. Cancer Res. 1993; 53: 2965-9.
17. 17. Fallon MB, Boyer JL. Hepatic toxicity of vitamin A and synthetic retinoids. J. Gastroenterol. Hepatol. 1990; 5: 334-42.