Valacyclovir inhibits recovery of ocular HSV-1 after experimental reactivation by excimer laser keratectomy

Cornea

Volumn 18, Issue 6, 1999, Pages 693-699

  Dhaliwal, Deepinder K ^a,d   Romanowski, Eric G ^a   Yates, Kathleen A ^a   Barnhorst, Donald A ^a   Goldstein, Michael ^a   Deeter, Robert G ^b   Fish, Douglas N ^c   Gordon, Y Jerold ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d University of Pittsburgh School of Medicine   (United States)

Author keywords

Animal model; Excimer laser keratectomy; Herpes simplex virus type l; Reactivation; Valacyclovir

Indexed keywords

ACICLOVIR; VALACICLOVIR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; EXCIMER LASER; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; KERATECTOMY; LASER SURGERY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; VIRUS INHIBITION; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS SHEDDING;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; CORNEA; EYE; FEMALE; HERPESVIRUS 1, HUMAN; INHIBITORY CONCENTRATION 50; LASER SURGERY; RABBITS; TRIGEMINAL GANGLION; VALINE; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS SHEDDING;

EID: 0032734336     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003226-199911000-00012     Document Type: Article

References (19)

1. McDonnell PJ, Moreira H, Clapham TN, et al. Photorefractive keratectomy for astigmatism. Arch Ophthalmol 1991;109:1370-3.
2. Pepose JS, Laycock KA, Miller JK, et al. Reactivation of latent herpes simplex virus by excimer laser photokeratectomy. Am J Ophthalmol 1992;114:45-50.
3. Vrabec MP, Anderson JA, Rock ME, et al. Electron microscopic findings in a cornea with a recurrence of herpes simplex keratitis after excimer laser phototherapeutic keratectomy. CLAO J 1994; 20:41-4.
4. Fagerholm P, Ohman L, Orndahl M. Phototherapeutic keratectomy in herpes simplex keratitis: clinical results in 20 patients. Acta Ophthalmol 1994;72:457-60.
5. Dhaliwal DK, Barnhorst DA, Romanowski EG, Rehkopf PG, Gordon YJ. Excimer laser keratectomy efficiently reactivates latent HSV-1 in the experimental rabbit ocular model. Am J Ophthalmol 1998;125:488-92.
6. Gordon YJ, Romanowski EG, Harwick J, Berman J, Olsakovsky L, Araullo-Cruz T. The effect of alpha blockage on iontophoresis-induced ocular shedding of latent HSV-1 W in different host animals. Curr Eye Res 1990;9:1007-14.
7. Gebhart BM, Kaufman HE. Propranolol suppresses reactivation of herpesvirus. Antiviral Res 1995;27:255-61.
8. Mertz GJ, Jones CC, Mills J, et al. Long-term acyclovir suppression of frequently recurring genital herpes simplex virus infection: a multicenter double-blind trial. JAMA 1988;260:201-6.
9. Mattison HR, Reichman RC, Benedetti J, et al. Double-blind placebo-controlled trial comparing long-term suppressive with short-term oral acyclovir therapy for the management of recurrent genital herpes. Am J Med 1988;85(suppl 2A):20-5.
10. Spruance SL, Hamill ML, Hoge WS, et al. Acyclovir prevents reactivation of herpes simplex labialis in skiers. JAMA 1988;260: 1597-9.
11. Rooney JF, Straus SE, Mannix ML, et al. Oral acyclovir to suppress frequently recurrent herpes labialis: a double-blind, placebo-controlled trial. Ann Intern Med 1993;118:268-72.
12. Simon AL, Pavan-Langston D. Long-term oral acyclovir therapy: effect on recurrent infectious herpes simplex keratitis in patients with and without grafts. Ophthalmology 1996;103:1399-405.
13. Rodriguez A, Power WJ, Neves RA, Foster CS. Recurrence rate of herpetic uveitis in patients on long-term oral acyclovir. Doc Ophthalmol 1995;90:331-40.
14. Herpetic Eye Disease Study Group. Acyclovir for the prevention of recurrent herpes simplex virus eye diseases. N Engl J Med 1998; 339:300-6.
15. Acosta EP, Fletcher CV. Valacyclovir. Ann Pharmacother 1997; 31:185-91.
16. Beutner KR. Valacyclovir: a review of its antiviral activity, pharmacokinetic properties and clinical efficacy. Antiviral Res 1995; 28:281-90.
17. O'Brien JJ, Campoli-Richards DM. Acyclovir: an updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs 1989;37:233-309.
18. Gordon YJ, Romanowski EG, Araullo-Cruz T. A fast simple reactivation method for the study of HSV-1 latency in the rabbit ocular model. Invest Ophthalmol Vis Sci 1990;31:921-4.
19. Valtrex Product Insert. Glaxo Wellcome Inc., 1996.