Ofloxacin photodegradation products possess antimicrobial activity

Drugs

Volumn 58, Issue SUPPL. 2, 1999, Pages 171-172

  Sunderland, J ^a   Tobin, C M ^a   White, L O ^a   MacGowan, A P ^a   Hedges, A J ^b  

^a NORTH BRISTOL NHS TRUST   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; CONFERENCE PAPER; NONHUMAN; PHOTODEGRADATION;

EID: 0032734058     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-199958002-00048     Document Type: Conference Paper

References (5)

1. Tiefenbacher E, Haen E, Przybilla B, et al. Photo degradation of some quinolones used as antimicrobial therapies. J Pharm Sci 1994; 83: 463-7
2. Phillips G, Johnson BE, Ferguson J. The loss of antibiotic activity of ciprofloxacin by photodegradation. J Antimicrob Chemother 1996; 26: 783-9
3. Korner RJ, McMullin CM, Bowker KA, et al. The serum concentrations of desmethyl ofloxacin and ofloxacin N-oxide in seriously ill patients and their possible contribution to the antimicrobial activity of ofloxacin. J Antimicrob Chemother 1993; 34: 300-3
4. White LO, MacGowam AP, Lovering AM, et al. A preliminary report on the pharmacokinetics of ofloxacin, des-methyl ofloxacin and ofloxacin N-oxide in patients with chronic renal failure. Drugs 1987; 34: Suppl. 1: 56-61
5. Finney DJ. Statistical methods in biological assay. 3rd ed. London: Griffin, 1978: 69-8