-
1
-
-
33745464490
-
Fluorinated pyrimidines a new class of tumour-inhibitory compounds
-
Heidelberger CH, Chaudhuri NK, Danneberg P, Mooren D, Griesbach L, Duschinsky R, Schnitzer RJ, Pleven E, Scheiner J. Fluorinated pyrimidines a new class of tumour-inhibitory compounds. Nature 1959;179: 663-666.
-
(1959)
Nature
, vol.179
, pp. 663-666
-
-
Heidelberger, C.H.1
Chaudhuri, N.K.2
Danneberg, P.3
Mooren, D.4
Griesbach, L.5
Duschinsky, R.6
Schnitzer, R.J.7
Pleven, E.8
Scheiner, J.9
-
2
-
-
0028088241
-
Current approaches to metastatic colorectal cancer
-
Kemeny N. Current approaches to metastatic colorectal cancer. Semin Oncol 1994;21:67-75.
-
(1994)
Semin Oncol
, vol.21
, pp. 67-75
-
-
Kemeny, N.1
-
3
-
-
0027980010
-
Preclinical and clinical aspects of biomodulation of 5-fluorouracil
-
Sotos GA, Grogan L, Allegra CJ. Preclinical and clinical aspects of biomodulation of 5-fluorouracil. Cancer Treat Rev 1994;20:11-49.
-
(1994)
Cancer Treat Rev
, vol.20
, pp. 11-49
-
-
Sotos, G.A.1
Grogan, L.2
Allegra, C.J.3
-
4
-
-
0019753942
-
On the rational development of a new drug: The example of the fluorinated pyrimidines
-
Heidelberger C. On the rational development of a new drug: the example of the fluorinated pyrimidines. Cancer Treat Rep 1981;65:3-9.
-
(1981)
Cancer Treat Rep
, vol.65
, pp. 3-9
-
-
Heidelberger, C.1
-
5
-
-
0019537132
-
The pharmacology of the fluoropyrimidines
-
Myers CE. The pharmacology of the fluoropyrimidines. Pharmacol Rev 1981;33:1-15.
-
(1981)
Pharmacol Rev
, vol.33
, pp. 1-15
-
-
Myers, C.E.1
-
7
-
-
0021233990
-
New approach to metabolism of 5′-deoxy-5-fluorouridine in humans with fluorine-19 NMR
-
Malet-Martino MC, Martino R, Lopez A, Béteille JP, Bon M, Bernadou J, Armand JP. New approach to metabolism of 5′-deoxy-5-fluorouridine in humans with fluorine-19 NMR. Cancer Chemother Pharmacol 1984;13: 31-35.
-
(1984)
Cancer Chemother Pharmacol
, vol.13
, pp. 31-35
-
-
Malet-Martino, M.C.1
Martino, R.2
Lopez, A.3
Béteille, J.P.4
Bon, M.5
Bernadou, J.6
Armand, J.P.7
-
8
-
-
0023931286
-
19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pretreatment
-
19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pretreatment. Cancer Res 1988;48:1680-1688.
-
(1988)
Cancer Res
, vol.48
, pp. 1680-1688
-
-
Hull, W.E.1
Port, R.2
Herrmann, R.3
Britsch, B.4
Kunz, W.5
-
9
-
-
0024757133
-
19F MRS studies of fluoropyrimidine chemotherapy. A review
-
19F MRS studies of fluoropyrimidine chemotherapy. A review. NMR Biomed 1989;2:133-141.
-
(1989)
NMR Biomed
, vol.2
, pp. 133-141
-
-
McSheehy, P.M.J.1
Griffiths, J.R.2
-
10
-
-
0025921621
-
19F magnetic resonance spectroscopy studies of the metabolism of 5-fluorouracil in murine RIF-1 tumors and liver
-
19F magnetic resonance spectroscopy studies of the metabolism of 5-fluorouracil in murine RIF-1 tumors and liver. Cancer Res 1991;51:1384-1390.
-
(1991)
Cancer Res
, vol.51
, pp. 1384-1390
-
-
Sijens, P.E.1
Huang, Y.2
Baldwin, N.J.3
Ng, T.C.4
-
11
-
-
0026360179
-
19F nuclear magnetic resonance spectroscopy
-
19F nuclear magnetic resonance spectroscopy. Cancer Res 1991;51:5806-5812.
-
(1991)
Cancer Res
, vol.51
, pp. 5806-5812
-
-
El-Tahtawy, A.A.1
Wolf, W.2
-
13
-
-
0023212874
-
Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy
-
Wolf W, Albright MJ, Silver MS, Weber H, Reichardt U, Sauer R. Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy. Magn Reson Imaging 1987;5:165-169.
-
(1987)
Magn Reson Imaging
, vol.5
, pp. 165-169
-
-
Wolf, W.1
Albright, M.J.2
Silver, M.S.3
Weber, H.4
Reichardt, U.5
Sauer, R.6
-
14
-
-
0025096726
-
19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits
-
19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits. Proc Natl Acad Sci USA 1990;87:492-496.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 492-496
-
-
Wolf, W.1
Presant, C.A.2
Servis, K.L.3
El-Tahtawy, A.4
Albright, M.J.5
Barker, P.B.6
Ring R. III7
Atkinson, D.8
Ong, R.9
King, M.10
Singh, M.11
Ray, M.12
Wiseman, C.13
Blayney, D.14
Shani, J.15
-
15
-
-
0025043987
-
19F nuclear magnetic resonance spectroscopy pharmacokinetics
-
19F nuclear magnetic resonance spectroscopy pharmacokinetics. J Clin Oncol 1990;8:1868-1873.
-
(1990)
J Clin Oncol
, vol.8
, pp. 1868-1873
-
-
Presant, C.A.1
Wolf, W.2
Albright, M.J.3
Servis, K.L.4
Ring R. III5
Atkinson, D.6
Ong, R.L.7
Wiseman, C.8
King, M.9
Blayney, D.10
Kennedy, P.11
El-Tahtawy, A.12
Singh, M.13
Shani, J.14
-
16
-
-
0025291181
-
19F magnetic resonance spectroscopy
-
19F magnetic resonance spectroscopy. Br J Radiol 1990;63:547-553.
-
(1990)
Br J Radiol
, vol.63
, pp. 547-553
-
-
Glaholm, J.1
Leach, M.P.2
Collins, D.3
Al Jehazi, B.4
Sharp, J.C.5
Smith, T.A.D.6
Adach, J.7
Hind, A.8
McCready, V.R.9
White, H.10
-
17
-
-
0025058615
-
Real-time follow-up of 5-fluorouracil metabolism in the liver of tumor patients by means of F-19 MR spectroscopy
-
Semmler W, Bachert-Baumann P, Gückel F, Ermark F, Schlag P, Lorenz WJ, van Kaick G. Real-time follow-up of 5-fluorouracil metabolism in the liver of tumor patients by means of F-19 MR spectroscopy. Radiology 1990;174:141-145.
-
(1990)
Radiology
, vol.174
, pp. 141-145
-
-
Semmler, W.1
Bachert-Baumann, P.2
Gückel, F.3
Ermark, F.4
Schlag, P.5
Lorenz, W.J.6
Van Kaick, G.7
-
21
-
-
0027303708
-
19F magnetic resonance spectroscopy in patients with colorectal cancer: A pilot study
-
19F magnetic resonance spectroscopy in patients with colorectal cancer: a pilot study. Ann Oncol 1993;4:597-602.
-
(1993)
Ann Oncol
, vol.4
, pp. 597-602
-
-
Findlay, M.P.1
Leach, M.O.2
Cunningham, D.3
Collins, D.J.4
Payne, G.S.5
Glaholm, J.6
Mansi, J.L.7
McCready, V.R.8
-
24
-
-
0030608756
-
19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine
-
19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine. Magn Reson Med 1997;38:907-916.
-
(1997)
Magn Reson Med
, vol.38
, pp. 907-916
-
-
Holland, S.K.1
Bergman, A.M.2
Zhao, Y.3
Adams, E.R.4
Pizzorno, G.5
-
25
-
-
0344251718
-
19F-NMR spectroscopy
-
(abstract), Berkeley
-
19F-NMR spectroscopy. In: Proceedings of the International Society for Magnetic Resonance in Medicine, vol 2 (abstract), Berkeley, 1997, p 1080.
-
(1997)
Proceedings of the International Society for Magnetic Resonance in Medicine
, vol.2
, pp. 1080
-
-
Adams, E.R.1
Leffert, J.J.2
Craig, D.J.3
Pizzorno, G.4
-
26
-
-
0030845828
-
5-Ethynyluracil (GW776): Effects on the formation of the toxic catabolites of 5-fluorouracil, fluoroacetate and fluorohydroxypropionic acid in the isolated perfused rat liver model
-
Arellano, Malet-Martino M, Martino R, Spector T. 5-Ethynyluracil (GW776): effects on the formation of the toxic catabolites of 5-fluorouracil, fluoroacetate and fluorohydroxypropionic acid in the isolated perfused rat liver model. Br J Cancer 1997;76:1170-1180.
-
(1997)
Br J Cancer
, vol.76
, pp. 1170-1180
-
-
Arellano1
Malet-Martino, M.2
Martino, R.3
Spector, T.4
-
27
-
-
0023187085
-
Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
-
Heggie GD, Sommadossi JP, Cross DS, Huster WJ, Diasio RB. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 1987;47:2203-2206.
-
(1987)
Cancer Res
, vol.47
, pp. 2203-2206
-
-
Heggie, G.D.1
Sommadossi, J.P.2
Cross, D.S.3
Huster, W.J.4
Diasio, R.B.5
-
28
-
-
0022481507
-
Potential of bromovinyldeoxyuridine in anticancer chemotherapy
-
De Clercq E. Potential of bromovinyldeoxyuridine in anticancer chemotherapy. Anticancer Res 1986;6:549-556.
-
(1986)
Anticancer Res
, vol.6
, pp. 549-556
-
-
De Clercq, E.1
-
29
-
-
0022550597
-
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice
-
Desgranges C, Razaka G, De Clercq E, Herdewijn P, Balzarini J, Drouillet F. Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice. Cancer Res 1986;46:1094-1101.
-
(1986)
Cancer Res
, vol.46
, pp. 1094-1101
-
-
Desgranges, C.1
Razaka, G.2
De Clercq, E.3
Herdewijn, P.4
Balzarini, J.5
Drouillet, F.6
-
30
-
-
0024337650
-
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5′-deoxy-5-fluorouridine against adenocarcinoma 755 in mice
-
Iigo M, Nishikata KI, Nakajima Y, Hoshi A, Okudaira N, Odagiri H, De Clercq E. Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5′-deoxy-5-fluorouridine against adenocarcinoma 755 in mice. Biochem Pharmacol 1989;38:1885-1889.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 1885-1889
-
-
Iigo, M.1
Nishikata, K.I.2
Nakajima, Y.3
Hoshi, A.4
Okudaira, N.5
Odagiri, H.6
De Clercq, E.7
-
31
-
-
0025687977
-
Effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine on life-span and 5-fluorouracil metabolism in mice with hepatic metastases
-
Iigo M, Nishikata KI, Nakajima Y, Hoshi A, De Clercq E. Effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine on life-span and 5-fluorouracil metabolism in mice with hepatic metastases. Eur J Cancer 1990;26:1089-1092.
-
(1990)
Eur J Cancer
, vol.26
, pp. 1089-1092
-
-
Iigo, M.1
Nishikata, K.I.2
Nakajima, Y.3
Hoshi, A.4
De Clercq, E.5
-
32
-
-
0028049685
-
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2′-deoxyuridine
-
Keizer HJ, De Bruijn EA, Tjaden UR, De Clercq E. Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2′-deoxyuridine. J Cancer Res Clin Oncol 1994;120:545-549.
-
(1994)
J Cancer Res Clin Oncol
, vol.120
, pp. 545-549
-
-
Keizer, H.J.1
De Bruijn, E.A.2
Tjaden, U.R.3
De Clercq, E.4
-
33
-
-
0032498318
-
Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral sorivudine
-
Ogura K, Nishiyama T, Takubo H, Kato A, Okuda H, Arakawa K, Fukushima M, Nagayama S, Kawaguchi Y, Watabe T. Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral sorivudine. Cancer Lett 1998;122: 107-113.
-
(1998)
Cancer Lett
, vol.122
, pp. 107-113
-
-
Ogura, K.1
Nishiyama, T.2
Takubo, H.3
Kato, A.4
Okuda, H.5
Arakawa, K.6
Fukushima, M.7
Nagayama, S.8
Kawaguchi, Y.9
Watabe, T.10
-
36
-
-
0013828726
-
Studies on the development, biochemistry and biology of experimental hepatomas
-
Morris HP. Studies on the development, biochemistry and biology of experimental hepatomas. Adv Cancer Res 1965;9:227-302.
-
(1965)
Adv Cancer Res
, vol.9
, pp. 227-302
-
-
Morris, H.P.1
-
38
-
-
0031661321
-
Intra-and extracellular fluorouracil uptake: Assessment with contrast-enhanced metabolic F-19 MR imaging
-
Brix G, Bellemann ME, Gerlach L, Haberkorn U. Intra-and extracellular fluorouracil uptake: assessment with contrast-enhanced metabolic F-19 MR imaging. Radiology 1998;209:259-267.
-
(1998)
Radiology
, vol.209
, pp. 259-267
-
-
Brix, G.1
Bellemann, M.E.2
Gerlach, L.3
Haberkorn, U.4
-
40
-
-
0026701936
-
Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil
-
Porter DJT, Chestnut WG, Merrill BM, Spector T. Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil. J Biol Chem 1992;267:5236-5242.
-
(1992)
J Biol Chem
, vol.267
, pp. 5236-5242
-
-
Porter, D.J.T.1
Chestnut, W.G.2
Merrill, B.M.3
Spector, T.4
-
41
-
-
0027489763
-
5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil
-
Baccanari DP, Davis ST, Knick VC, Spector T. 5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil. Proc Natl Acad Sci USA 1993;90:11064-11068.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11064-11068
-
-
Baccanari, D.P.1
Davis, S.T.2
Knick, V.C.3
Spector, T.4
-
42
-
-
0028281781
-
5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
-
Cao S, Rustum YM, Spector T. 5-Ethynyluracil (776C85): modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Res 1994;54:1507-1510.
-
(1994)
Cancer Res
, vol.54
, pp. 1507-1510
-
-
Cao, S.1
Rustum, Y.M.2
Spector, T.3
-
43
-
-
0031060493
-
Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: Allometric scaling of human data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans
-
Khor SP, Amyx S, Davis ST, Nelson D, Baccanari DP, Spector T. Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of human data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans. Cancer Chemother Pharmacol 1997;39:223-238.
-
(1997)
Cancer Chemother Pharmacol
, vol.39
, pp. 223-238
-
-
Khor, S.P.1
Amyx, S.2
Davis, S.T.3
Nelson, D.4
Baccanari, D.P.5
Spector, T.6
-
44
-
-
0028935442
-
A perspective on k-space
-
Mezrich R. A perspective on k-space. Radiology 1995;195:297-315.
-
(1995)
Radiology
, vol.195
, pp. 297-315
-
-
Mezrich, R.1
-
45
-
-
0030763054
-
18F]fluorouracil tissue concentrations measured with positron emission tomography in patients with liver metastases from colorectal adenocarcinoma
-
18F]fluorouracil tissue concentrations measured with positron emission tomography in patients with liver metastases from colorectal adenocarcinoma. Cancer Res 1997;54:3415-3423.
-
(1997)
Cancer Res
, vol.54
, pp. 3415-3423
-
-
Kissel, J.1
Brix, G.2
Bellemann, M.E.3
Strauss, L.G.4
Dimitrakopoulou-Strauss, A.5
Port, R.6
Haberkorn, U.7
Lorenz, W.J.8
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