Effect of oral administration of vitamin C on human aqueous humor ascorbate concentration

Acta Pharmacologica Sinica

Volumn 20, Issue 10, 1999, Pages 879-883

  Iqbal, Zafar ^a,d   Midgley, John M ^a   Watson, David G ^a   Karditsas, Stilianous D ^b   Dutton, Gordon N ^b   Wilson, William S ^c  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b WESTERN INFIRMARY   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF PESHAWAR   (Pakistan)

Author keywords

Aqueous humour; Ascorbic acid; Cataract extraction; High pressure liquid chromatography; Hydroquinones; Plasma

Indexed keywords

ASCORBIC ACID;

AQUEOUS HUMOR; ARTICLE; CATARACT; CATARACT EXTRACTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; GLAUCOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAOCULAR PRESSURE; ORAL DRUG ADMINISTRATION; VITAMIN INTAKE;

AGED; AGED, 80 AND OVER; AQUEOUS HUMOR; ASCORBIC ACID; CATARACT; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 0032729951     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Cole DF. Aqueous abd ciliary body. In: Graymore CN, editor. Biochemistry of the eye. London: Academic Press; 1970. p105-82.
2. Johnsen H, Ringvold A, Blika S. Ascorbic acid determination in serum and aqueous humour by high-performance liquid chromatography. Acta Ophthalmol 1985; 63; 31-4.
3. Rose CR, Bode AM. Ocular ascorbate transport and metabolism. Comp Biochem Physiol 1991; 100: 273-85.
4. Heath H. The distribution and possible functions of ascorbic acid in eye. Exp Eye Res 1962; 1: 362-7.
5. Peterson CA, O'Rourke MC. Vitamin-C levels in human tears. Arch Ophthalmol 1987; 105: 376-7.
6. Linner E. Drug mechanism in glaucoma. In: Paterson G, Miller SJH, Paterson DG, editors. London; J & A Churchill; 1966. p153-64.
7. Watson DG, Iqbal Z, Midgley JM, Pryce-Jones H, Morrison L, Dutton GN, et al. Measurement of ascorbic acid in human aqueous humour, plasma and bovine aqueous humour by high-performance liquid chromatography with electrochemical detector. J Pharm Biomed Anal 1993; 11: 389-92.
8. Tsao CS, Salimi SL. Ultramicromethod for the measurement of ascorbic acid in plasma and white blood cells by HPLC with electrochemical detector. J Chromatogr 1981; 224: 477-9.
9. Taylor A, Jacques FP, Nadler D, Morrow F, Sulsky SI, Shepard D. Relationship in humans between ascorbic acid consumption and level of total and reduced ascorbic acid in lens, aqueous humour and plasma. Curr Eye Res 1991; 10: 751-9.
10. Etzol DFK, Lee PF, Lam KW. Factors affecting ascorbate oxidation in aqueous humour. Curr Eye Res 1987; 6; 357 -61.
11. Ruusuvaara P, Pajari S, Setala K. Effect of sodium hyaluronate on immediate post operative IOP after extracapsular cataract extraction and IOL implantation. Acta Ophthalmol 1990; 68: 721-7.
12. Liebmann, JM, Ritch R, Disclafani M, Stock L. Early intraocular pressure rise after trabeculectomy. Arch Ophthalmol 1990; 108: 1549-52.
13. Niedermeier W, Laney RP, Dobson C. The mechanism of action of ceruloplasmin in inhibiting the ascorbic acid-induced depolymerization of hyaluronic acid. Biochim Biophys Acta 1967; 148: 400-5.
14. Fink MR, Lengfelder E. Hyaluronic acid degradation by ascorbic acid and influence of iron. Free Rad Res Commun 1987; 3: 85-92.
15. Carreras PJ, Lopez Caballero JJ, Porcel D. A gel of glycosaminoglycans lining the anterior and posterior chambers in man: histochemical evidence at light and electron microscopy levels. Eye 1992; 6 (Pt 6): 574-82.