Demethylation of the Epstein-Barr virus origin of lytic replication and of the immediate early gene BZLF1 is DNA replication independent

Archives of Virology

Volumn 144, Issue 11, 1999, Pages 2219-2227

  Falk, K I ^a   Ernberg, I ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DEMETHYLATION; DNA REPLICATION; EPSTEIN BARR VIRUS; VIRAL GENETICS; VIRUS REPLICATION;

ANTIGENS, VIRAL; ANTIVIRAL AGENTS; AZACITIDINE; DNA METHYLATION; DNA REPLICATION; DNA, VIRAL; DNA-BINDING PROTEINS; FOSCARNET; HERPESVIRUS 4, HUMAN; HUMANS; REPLICATION ORIGIN; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; VIRAL PROTEINS; VIRUS REPLICATION;

ANIMALIA; DNA VIRUSES; HUMAN HERPESVIRUS 4;

EID: 0032729023     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007050050636     Document Type: Article

References (40)

1. 1. Anagnostopoulos I, Hummel M, Stein H (1995) Frequent presence of latent Epstein-Barr virus infection in peripheral T cell lymphomas. A review. Leukemia Lymphoma 19: 1-12
2. 2. Antequera F, Boyes J, Bird A (1990) High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 62: 503-514
3. 3. Bestor TH (1990) DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes. [Review]. Phil Trans Soc London Ser B 326: 179-187
4. 4. Bird AP (1995) Gene number, noise reduction and biological complexity [see comments]. [Review]. Trends Genet 11: 94-100
5. 5. Burnett TS, Sleeman JP (1984) Uneven distribution of methylation sites within the human papillomavirus la genome: possible relevance to viral gene expression. Nucleic Acids Res 12: 8848-8860
6. 6. Cedar H (1988) DNA methylation and gene activity. [Review]. Cell 53: 3-4
7. 7. Doerfler W (1983) DNA methylation and gene activity. [Review]. Ann Rev Biochem 52: 93-124
8. 8. Doerfler W (1990) The significance of DNA methylation patterns: promoter inhibition by sequence-specific methylation is one functional consequence. Phil Trans R Soc London Ser B 326: 253-265
9. 9. Epstein MA, Achong BG, Barr YM (1964) Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet I: 702-703
10. 10. Ernberg I, Falk K, Minarovits J, Busson P, Tursz T, Masucci MG, Klein G (1989) The role of methylation in the phenotype-dependent modulation of Epstein-Barr nuclear antigen 2 and letent membrane protein genes in cells latently infected with Epstein-Barr virus [published erratum appears in J Gen Virol 1990 Feb; 71(Pt 2): 499]. J Gen Virol 70: 2989-3002
11. 11. Falk K, Ernberg I (1993) An origin of DNA replication (oriP) in highly methylated episomal Epstein-Barr virus DNA localizes to a 4.5-kb unmethylated region. Virology 195: 608-615
12. 12. Fronko GE, Long WK, Wu B, Papadopoulos T, Henderson EE (1989) Relationship between methylation status and expression of an Epstein-Barr (EBV) capsid antigen gene. Biochem Biophys Res Commun 159: 263-270
13. 13. Hammerschmidt W, Sugden B (1988) Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus. Cell 55: 427-433
14. 14. Henle G, Henle W, Diehl V (1968) Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis. Proc Natl Sci USA 59: 94-101
15. 15. Henle W, Henle GE, Horwitz CA (1974) Epstein-Barr virus specific diagnostic tests in infectious mononucleosis. [Review]. Hum Pathol 5: 551-565
16. 16. Hoeben RC, Migchielsen AA, van der Jagt RC, van Ormondt H, van der Eb AJ (1991) Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position. J Virol 65: 904-912
17. 17. Holliday R (1979) A new theory of carcinogenesis. Br J Cancer 40: 513-522
18. 18. Hu LF, Minarovits J, Cao SL, Contreras-Salazar B, Rymo L, Falk K, Klein G, Ernberg I (1991) Variable expression of latent membrane protein in nasopharyngeal carcinoma can be related to methylation status of the Epstein-Barr virus BNLF-1 5′-flanking region. J Virol 65: 1558-1567
19. 19. Imai S, Koizumi S, Sugiura M, Tokunaga M, Uemura Y, Yamamoto N, Tanaka S, Sato E, Osato T (1994) Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc Natl Acad Sci USA 91: 9131-9135
20. 20. Jost JP, Saluz HP, McEwan I, Feavers IM, Hughes M, Reiber S, Liang HM, Vaccaro M (1990) Tissue specific expression of avian vitellogenin gene is correlated with DNA hypomethylation and in vivo specific protein-DNA interactions. Phil Trans R Soc London Ser B 326: 231-240
21. 21. Klein E, Klein G, Nadkarni JJ, Wigzell H, Clifford P (1968) Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture cell lines. Cancer Res 28: 1300-1310
22. 22. Klein G, Dombos L, Gothoskar B (1972) Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus. Int J Cancer 10: 44-57
23. 23. Larocca D, Homisak D, Clough W (1981) Synthesis of hypomethylated Epstein-Barr viral DNA is stimulated by dimethylsulfoxide treatment of lymphoblastoid cells. Biochem Biophys Res Commun 100: 559-565
24. 24. Lei H, Oh SP, Okano M, Juttermann R, Goss KA, Jaenisch R, Li E (1996) De nov DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122: 3195-3205
25. 25. Lewis JD, Meehan RR, Henzel WJ, Maurer-Fogy I, Jeppesen P, Klein F, Bird A (1992) Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69: 905-914
26. 26. Long WK, Fronko GE, Lindemeyer RG, Wu B, Henderson EE (1987) Effects of S-adenosylhomocysteine and analogs on Epstein-Barr virus-induced transformation, expression of the Epstein-Barr virus capsid antigen, and methylation of Epstein-Barr virus DNA. J Virol 61: 221-224
27. 27. Lozzio BB, Lozzio CB (1977) Properties of the K562 cell line derived from a patient with chronic myeloid leukemia [letter]. Int J Cancer 19: 136
28. 28. Masucci MG, Contreras-Salazar B, Ragnar E, Falk K, Minarovits J, Ernberg I, Klein G (1989) 5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael. J Virol 63: 3135-3141
29. 29. Masucci MG, Contreras-Salazar B, Ragnar E, Falk K, Minarovits J, Ernberg I, Klein G (1989) 5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael. J Virol 63: 3135-3141
30. 30. Meehan RR, Lewis JD, Bird AP (1992) Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA. Nucleic Acids Res 20: 5085-5092
31. 31. Meehan RR, Lewis JD, McKay S, Kleiner EL, Bird AP (1989) Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell 58: 499-707
32. 32. Miller G, Lipman M (1973) Release of infectious Epstein-Barr virus by transformed marmoset leukocytes. Proc Natl Acad Sci USA 70: 190-194
33. 33. Minarovits J, Minarovits-Kormuta S, Ehlin-Henriksson B, Falk K, Klein G, Ernberg I (1991) Host cell phenotype-dependent methylation patterns of Epstein-Barr virus DNA. J Gen Virol 72: 1591-1599
34. 34. Nonkwelo CB, Long WK (1993) Regulation of Epstein-Barr virus BamHI-H divergent promoter by DNA methylation. Virology 197: 205-215
35. 35. Nutter LM, Grill SP, Li JS, Tan RS, Cheng YC (1987) Induction of virus enzymes by phorbol esters and n-butyrate in Epstein-Barr virus genome-carrying Raji cells. Cancer Res 47: 4407-4412
36. 36. Perlmann C, Saemundsen AK, Klein G (1982) A fraction of Epstein-Barr virus virion DNA is methylated in and around the EcoRI-J fragment. Virology 123: 217-221
37. 37. Razin A, Riggs AD (1980) DNA methylation and gene function [Review]. Science 210: 604-610
38. 38. Selker EU (1990) DNA methylation and chromatin structure: a view from below [Review] Trends Biochem Sci 15: 103-107
39. 39. Szyf M, Eliasson L, Mann V, Klein G, Razin A (1985) Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle. Proc Natl Acad Sci USA 82: 8090-8094
40. 40. Zur Hausen H, Schulte-Holthausen H (1970) Presence of EB virus nucleic acid homology in a "virus-free" line of Burkitt tumour cells. Nature 227: 245-248