Molecular aspects of the endocrine tumours of the pancreas and the gastrointestinal tract

Italian Journal of Gastroenterology and Hepatology

Volumn 31, Issue 7 SUPPL. 2, 1999, Pages

  Rindi, G ^a   Candusso, M E ^b   Solcia, E ^b  

^a Istituto di Anatomia Patologica   (Italy)

^b NONE

Author keywords

Ki67; Loss of heterozygosity; MEN 1 gene; Neuroendorine tumours; p53; Retinoblastoma gene

Indexed keywords

CARCINOID; CONFERENCE PAPER; GASTROINTESTINAL TUMOR; HETEROZYGOSITY LOSS; MOLECULAR BIOLOGY; MULTIPLE ENDOCRINE NEOPLASIA; NEUROENDOCRINE TUMOR; PANCREAS ISLET CELL TUMOR; PANCREAS TUMOR; STOMACH CANCER;

FEMALE; GASTROINTESTINAL NEOPLASMS; GENETIC MARKERS; HUMANS; MALE; MOLECULAR BIOLOGY; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS; SENSITIVITY AND SPECIFICITY;

EID: 0032728203     PISSN: 11258055     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Solcia E, Capella C, Fiocca R, Sessa F, La Rosa S, Rindi G. Disorders of the endocrine system. In: Ming SMC, Goldman H, editors. Pathology of the gastrointestinal tract. Philadelphia: Saunders; 1998.
2. Corallini A, Altavilla G, Cecchetti MG, Fabris G, Grossi MP, Balboni PG, et al. Ependymomas, malignant tumors of pancreatic islets and osteosarcomas induced in hamsters by B K virus, a human papovavirus. J Natl Cancer Inst 1978;61:875-83.
3. Pater MM, Pater A, Fiori M, Slota J, di Mayorca G. BK virus sequences in human tumors and normal tissues and cell lines. In: Essex M, Todaro G, Zur Hausen H, editors. Viruses in naturally occurring cancers. Cold Spring Harbor: Cold Spring Harbor Lab; 1980. p. 329-41.
4. Caputo A, Corallini A, Grossi MP, Carrà L, Balboni PG, Negrini M, et al. Episomal DNA of a BK virus variant in a human insulinoma. J Med Virol 1982;12:37-49.
5. Probst A, Lotz M, Heitz P. Von Hippel-Lindau's disease, syringomyelia and multiple endocrine tumors: a complex neuroen-docrinopathy. Virchows Arch Anat Path Histol 1978;378:265-72.
6. Griffiths DFR, Williams GT, Williams ED. Duodenal carcinoid tumours, phaeochromocytomas and neurofibromatosis: islet cell tumour, phaeochromocytoma and the von Hippel-Lindau complex: two distinctive neuroendocrine syndromes. Quart J Med 1987;245:769-82.
7. Lott ST, Curley SA, Killary AM. Loss of heterozygosity at 31p13-3p21 in pancreatic islet cell tumors associated with von Hippel Lindau disease. Proc Am Ass Cancer Res 1994;35:A572.
8. Komminoth P, Roth J, Muletta-Feurer S, Saremaslani P, Seelentag WKF, Heitz PU. Ret proto oncogene pont mutation in sporadic neuroendocrine tumors. J Clin Endocrinol Metab 1996;81:2041-6.
9. Larsson K, Skogseid B, Öberg K, Nakamura Y, Nordenskjöld M. Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature 1988;332:85-7.
10. Teh BT, Hayward NK, Wilkinson S, Woods GM, Cameron D, Sheperd JJ. Clonal loss of INT-2 alleles in sporadic and familial pancreatic endocrine tumours. Br J Cancer 1990;62:253-4.
11. Bale AE, Norton JA, Wong EL, Fryburg JS, Maton PN, Oldfield EH, et al. Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1. Cancer Res 1991;51:1154-7.
12. Lubensky IA, Debelenko LV, Zhuang Z, Emmert-Buck MR, Dong Q, Chandrasekharappa S, et al. Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN-1 patients. Cancer Res 1996;56:5272-8.
13. Debelenko LV, Zhuang Z, Emmert-Buck MR, Chandrasekharappa S, Manickam P, Guru SC, et al. Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors. Cancer Res 1997;57:2238-43.
14. Zhuang Z, Bertheau P, Emmert-Buck MR, Liotta LA, Gnarra J, Linehan WM, et al. A microdissection technique for archival DNA analysis of specific cell populations in lesions less than one millimeter in size. Am J Pathol 1995;146:620-5.
15. Beckers A, Abs R, Reyners E, De Boulle K, Steveanert A, Heller FR, et al. Variable regions of chromosome 11 loss in different pathological tissues of a patient with the multiple endocrine neoplasia type 1 syndrome. J Clin Endocrinol Metab 1994;79:1498-502.
16. Debelenko LV, Emmert-Buck MR, Zhuang Z, Epshteyn E, Moskaluk CA, Jensen RT, et al. The multiple endocrine neoplasia type 1 gene locus is involved in the pathogenesis of type II gastric carcinoids. Gastroenterology 1997;113:773-81.
17. Jakobovitz O, Nass D, DeMarco L, Barbosa AJA, Simoni FB, Rechavi G, Friedman E. Carcinoid tumors frequently display genetic abnormalities involving chromosome 11. J Clin Endocrinol Metab 1996;81:3164-7.
18. Yokota J, Sugimura T. Multiple steps in carcinogenesis involving alterations of multiple tumor suppressor genes. FASEB J 1993;7:920-5.
19. Malkin D, Li FP, Strong LC, Fraumeni JF jr, Nelson CE, Kim DH, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990;250:1233-8.
20. Rindi G, Transgenic models of endocrine tumors. In Polak JM, editor. Diagnostic histopathology of neuroendocrine tumors. London: Churchill-Livingstone; 1993. p. 67-89.
21. Ludlow JW. Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRb and p53. FASEB J 1993;7:866-71.
22. Messing A, Chen HY, Palmiter RD, Brinster RL. Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice. Nature 1985;316:461-3.
23. Reynolds RK, Hoekzema GS, Vogel J, Hinrichs SH, Jay G. Multiple endocrine neoplasia induced by the promiscuous expression of a viral oncogene. Proc Natl Acad Sci USA 1988;85:3135-9.
24. Harvey M, Vogel HM, Lee EYHP, Bradley A, Donehower LA. Mice deficient in both p53 and Rb develop tumours primarily of endocrine origin. Cancer Res 1995;55:1146-51.
25. Pearce SH, Trump D, Wooding C, Sheppard MN, Clayton RN, Thakker RV. Loss of heterozygosity studies at the retinoblastoma and breast cancer susceptibility (BRCA2) loci in pituitary, parathyroid, pancreatic and carcinoid tumours. Clin Endocrinol 1996;45:195-200.
26. Yashimoto K, Iwahana H, Fukuda A, Sano T, Saito S, Itakura M. Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction - single strand conformation polymorphism. Cancer Res 1992;52:5061-4.
27. Lohman DR, Funk A, Niedermeyer HP, Häupel S, Höfler H. Identification of p53 gene mutations in gastrointestinal and pancreatic carcinoids by nonradioisotopic SSCA. Virchows Arch B 1993;64:293-6.
28. Bartz C, Ziske C, Wiedenmann B, Moelling K. p53 tumour suppressor gene expression in pancreatic neuroendocrine tumour cells. Gut 1996;38:403-9.
29. Pellegata NS, Sessa F, Renault B, Bonato M, Leone BE, Solciaia E, et al. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res 1994;54:1556-60.
30. La Rosa S, Sessa F, Capella C, Riva C, Leone BE, Klersy C, et al. Prognostic criteria in nonfunctioning endocrine tumors. Virchows Arch 1996;429:323-33.
31. Rindi G, Stolte M, Capella C, Bordi C, Solcia E. Prognostic factors of gastric endocrine tumors. In preparation.
32. Vortmeyer AO, Lubensky IA, Merino MJ, Wang CY, Pham T, Furth EE, et al. Concordance of genetic alterations in poorly differentiated neuroendocrine carcinomas and associated adenocarcinomas. J Natl Cancer Inst 1997;89:1448-53.
33. Azzoni C, Doglioni C, Viale G, Delle Fave G, De Boni M, Caruana P, et al. Involvement of BCL-2 oncoprotein in the development of enterochromaffin-like cell gastric carcinoids. Am J Surg Pathol 1996;20:433-41.
34. Chaudry A, Öberg K, Wilander E. A study of biological behavior on the expression of a proliferating antigen in neuroendocrine tumors of the digestive system. Tumor Biol 1992;13:27-35.
35. Pelosi G, Zamboni G, Doglioni C, Rodella S, Iacono C, Serio G, et al. Immunodetection of proliferating cell nuclear antigen assesses the growth fraction and predicts malignancy in endocrine tumors of the pancreas. Am J Surg Pathol 1992;16:1215-25.
36. Pelosi G, Bresaola E, Bogina G, Pasini F, Rodella S, Castelli P, et al. Endocrine tumors of the pancreas: Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy. Hum Path 1996;27:1125-34.