How the most common preservative affects the Meibomian lipid layer

Orbit

Volumn 18, Issue 2, 1999, Pages 89-97

  Kaercher, T ^a   Honig D ^b   Barth, W ^c  

^a Augenklin des Staedt Klinikums   (Germany)

^b Nanofilm Technologie   (Germany)

^c ALLERGAN PLC   (United States)

Author keywords

Benzalkonium chloride; Cytotoxic effect; Meibomian gland secretion; Preservative; Tear film lipids

Indexed keywords

BENZALKONIUM CHLORIDE; EYE DROPS; LIPID; PRESERVATIVE;

ARTICLE; HUMAN; IN VITRO STUDY; LACRIMAL FLUID; MEIBOMIAN GLAND; SURFACE TENSION;

EID: 0032728140     PISSN: 01676830     EISSN: None     Source Type: Journal    
DOI: 10.1076/orbi.18.2.89.2717     Document Type: Article

References (12)

1. Burstein N L: Preservative alteration of corneal permeability in humans and rabbits. Invest. Ophthalmol Vis Sci 1984;25:1453-1457.
2. Champeau E J, Edelhauser H F: Effect of ophthalmic preservatives on the ocular surface: Conjunctival and corneal uptake and distribution of benzalkonium chloride and chlorhexidine digluconate. In F.J. Holly (ed): The precorneal tear film in health, disease and contact lens wear. Lubbock 1986:292-302.
3. R. Neville, Dennis P, Sens D, Crouch R: Preservative cytotoxicity to cultured epithelial cells. Current Eye Research 1986;5:367-372.
4. Imperia P S, Lazarus H M, Botti R E, Lass J H: An in vitro method for measuring ophthalmic preservative cytotoxicity. J Toxicol 1986;5:309-317.
5. Sasaki H, Nagano T, Yamamura K, Nishida K, Nakamura J: Ophthalmic preservatives as absorption promoters for ocular drug delivery. J Pharm Pharmacol 1995;47:703-707.
6. Wilson W S, Duncan A J, Jay J L: Effect of benzalkonium chloride on the stability of precorneal tear film in rabbit and man. Br J Ophthalmol 1975;59:667-669.
7. Norn M S, Opauszki A: Effects of ophthalmic vehicles on the stability of the precorneal film. Acta Ophthalmol 1977;55:23-34.
8. Kaercher T, Hönig D, Möbius D: Brewster Angle Microscopy - a new method of visualizing the spreading of meibomian lipids. Int Ophthalmol 1993;17:341-348.
9. Gasset A, Ishii Y, Kaufman H E, Miller T: Cytotoxicity of ophthalmic preservatives. Am J Ophthalmol 1974;78:98-105.
10. Hönig D, Möbius D: Direct visualization of monolayers at the air water interface by Brewster Angle Microscopy. J Phys. 1991;95:4590-4592.
11. Salonen E M, Vaheri A, Tervo T, Beuerman R: Toxicity of ingredients in artificial tears and ophthalmic drugs in a cell attachment and spreading test. J Toxicol 1991;10:57-166.
12. Bonatz E, Brewitt H: Morphological studies of the corneal epithelium before and after application of topical ophthalmic drugs. In F.J. Holly (ed): The precorneal tear film in health, disease and contact lens wear. Lubbock 1986:280-291.