Microwave assisted selective cleavage of sulfonates and sulfonamides in dry media

Synlett

Volumn , Issue 11, 1999, Pages 1745-1746

  Sabitha, Gowravaram ^a   Abraham, Sunny ^a   Reddy, B V Subba ^a   Yadav, J S ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

KF Al2O3; Microwave irradiation; Sulfonamides; Sulfonates

Indexed keywords

SULFONAMIDE; SULFONIC ACID DERIVATIVE;

ARTICLE; CHEMICAL PROCEDURES; CHEMICAL REACTION; CHEMICAL STRUCTURE; MICROWAVE RADIATION;

EID: 0032726844     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-2940     Document Type: Article

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14. 3 (3 weight equivalents of sulfonate) were admixed in a pyrex test tube and subjected to microwave irradiation for 5min. The solid mass was allowed to cool to room temperature, and was extracted with ethyl acetate (2 x 15ml). The organic layer was concentrated in vacuo and was purified by column chromatography on silica gel (100-200 mesh, ethyl acetate-hexane 2:8) to afford indole (4a, 1.03g, 88% yield) as a white solid.
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