Cardiovascular risk, renal hypertensive damage, and effects of amlodipine treatment in transgenic TGR(mREN2)27 rats

General Pharmacology

Volumn 33, Issue 5, 1999, Pages 423-430

  Witte, K ^a   Schnecko, A ^a   Schmidt, T ^a   Voll, C ^a   Kranzlin B ^b   Lemmer, B ^a  

^a Urologische Klinik   (Germany)

^b Medical Faculty   (Germany)

Author keywords

Albumin; Amlodipine; Circadian rhythm; Corticosteroids; Hypertension; Kidney; Proteinuria; Transgenic rat

Indexed keywords

AMLODIPINE; CORTICOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RISK; CIRCADIAN RHYTHM; CONTROLLED STUDY; CREATININE CLEARANCE; HISTOLOGY; HYPERTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; RAT; STRAIN DIFFERENCE; TRANSGENIC ANIMAL; URINARY EXCRETION;

ALBUMINS; AMLODIPINE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD PRESSURE; CALCIUM; CALCIUM CHANNEL BLOCKERS; CARDIOVASCULAR DISEASES; CIRCADIAN RHYTHM; DRUG EVALUATION, PRECLINICAL; HYPERTENSION; KIDNEY DISEASES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RISK FACTORS; SPECIES SPECIFICITY;

EID: 0032726841     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(99)00037-3     Document Type: Article

References (29)

1. Ackermann H. BiAS. biometrische analyse von stichproben 6th ed:1997;Epsilon-Verlag, Hochheim-Darmstadt.
2. Bachmann S., Peters J., Engler E., Ganten D., Mullins J. Transgenic rats carrying the mouse renin gene. morphological characterization of a low-renin hypertension model Kidney Int. 41:1992;24-36.
3. Böhm M., Lee M.A., Kreutz R., Kim S., Schinke M., Djavidani B., Wagner J., Kaling M., Wienen W., Bader M., Ganten D. Angiotensin II receptor blockade in TGR(mREN2)27. effects of renin-angiotensin-system gene expression and cardiovascular functions J Hypertens. 13:1995;891-899.
4. 4. Am J Physiol. 250:1986;F827-F833.
5. Cirillo M., Galletti F., Strazzullo P., Torielli L., Melloni M.C. On the pathogenetic mechanism of hypercalciuria in genetically hypertensive rats of the Milan strain. Am J Hypertens. 2:1989;741-746.
6. Dworkin L.D., Levine R.I., Benstein J.A., Parker M., Ullian M.E., Kim Y., Feiner H.D. Effects of nifedipine and enalapril on glomerular injury in rats with deoxycorticosterone-salt hypertension. Am J Physiol. 259:1990;F598-F604.
7. Dworkin L.D., Feiner H.D., Parker M., Tolbert E. Effects of nifedipine and enalapril on glomerular structure and function in uninephrectomized SHR. Kidney Int. 39:1991;1112-1117.
8. Dworkin L.D., Benstein J.A., Parker M., Tolbert E., Feiner H.D. Calcium antagonists and converting enzyme inhibitors reduce renal injury by different mechanisms. Kidney Int. 43:1993;808-814.
9. Dworkin L.D., Tolbert E., Recht P.A., Hersch J.C., Feiner H., Levin R.I. Effects of amlodipine on glomerular filtration, growth, and injury in experimental hypertension. Hypertension. 27:1996;245-250.
10. Fanestil D.D., Vaughn D.A., Ma L., Hyde R.H., Printz M.P. Thiazide diuretics normalize urinary calcium in spontaneously hypertensive male rats. Kidney Int. 51:1997;1018-1021.
11. Kanno Y., Suzuki H., Okada H., Saruta T. Renal protective effects of amlodipine on partially nephrectomized spontaneously hypertensive rats fed a high-salt diet. J Cardiovasc Pharmac. 23:1994;480-484.
12. Kanno Y., Okada H., Suzuki H., Ikenaga H., Ishii N., Itoh H., Saruta T. Does combined therapy of Ca-channel blocker and angiotensin converting enzyme inhibitor exceed monotherapy in renal protection against hypertensive injury in rats. Clin Exp Hypertens. 18:1996;243-256.
13. Kuwajima I., Suzuki Y., Shimosava T., Kanemaru A., Hoshino S., Kuramoto K. Diminished nocturnal decline in elderly hypertensive patients with left ventricular hypertrophy. Am Heart J. 67:1992;1307-1311.
14. Lemmer, B., 1999. Genetic aspects of chronobiologic rhythms in cardiovascular disease. In: Breithardt, G., Zehender, M. (Eds.), From molecule to men - molecular basis of congenital cardiovascular disorder. Steinkopff, Darmstadt (in press).
15. Lemmer B., Mattes A., Böhm M., Ganten D. Circadian blood pressure variation in transgenic hypertensive rats. Hypertension. 22:1993;97-101.
16. Mann J.F.E., Johnson A.K., Ganten D. Plasma angiotensin II. dipsogenic levels and angiotensin generating capacity of renin Am J Physiol. 238:1980;R372-R377.
17. McCarron D.A., Yung N.N., Ugoretz B.A., Krutzik S. Disturbances of calcium metabolism in the spontaneously hypertensive rat. Hypertension. 3:1981;I162-I167.
18. Middeke M., Schrader J. Nocturnal blood pressure in normotensive subjects and those with white coat, primary, and secondary hypertension. Br Med J. 308:1994;630-632.
19. Mullins J.J., Peters J., Ganten D. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 renin gene. Nature. 344:1990;541-544.
20. Pinto Y.M., Buikema H., van Gilst W.H., Scholtens E., van Geel P.P., de Graeff P.A., Wagner J., Paul M. Cardiovascular end-organ damage in Ren-2 transgenic rats compared to spontaneously hypertensive rats. J Mol Med. 75:1997;371-377.
21. Pons M., Schnecko A., Witte K., Lemmer B., Waterhouse J.M., Cambar J. Circadian rhythms in renal excretion and hemodynamics in Sprague-Dawley normotensive and transgenic TGR(mRen-2)27 hypertensive rats. Am J Physiol. 271:1996;R1002-R1008.
22. Sander M., Bader M., Djavidani B., Maser-Gluth C., Vecsei P., Mullins J., Ganten D., Peters J. The role of the adrenal gland in hypertensive transgenic rat TGR(mREN2)27. Endocrinology. 131:1992;807-814.
23. Schnecko A., Witte K., Schänzer A., Lemmer B. Circadian rhythms in plasma renin and converting enzyme activity, corticosterone and aldosterone concentration in normotensive Sprague-Dawley and transgenic hypertensive rats. Biol Rhythm Res. 26:1995;442. (abstract).
24. Springate J.E., Feld L.G., Ganten D. Renal function in hypertensive rats transgenic for mouse renin gene. Am J Physiol. 266:1994;F731-F737.
25. Springate J.E., Feld L.G., Ganten D. Enalapril and renal function in hypertensive rats transgenic for the mouse renin gene. Hypertension. 30:1997;868-872.
26. Timio M., Venanzi S., Lolli S., Lippi G., Verdura C., Monarca C., Guerrini E. "Non-dipper" hypertensive patients and progressive renal insufficiency. a 3-year longitudinal study Clin Nephrol. 43:1995;382-387.
27. Verdecchia P., Schillaci G., Guerrieri M., Gatteschi C., Benemio G., Boldrini F., Porcellati C. Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension. Circulation. 81:1990;528-536.
28. Wagner C., Krämer B.K., Hinder M., Kieninger M., Kurtz A. T-type and L-type calcium channel blockers exert opposite effects in renin secretion and renin gene expression in conscious rats. Br J Pharmac. 124:1998;579-585.
29. Witte K., Zuther P., Lemmer B. Analysis of telemetric time series data for periodic components using DQ-FIT. Chronobiol Int. 14:1997;561-574.