Ceramide-induced vasorelaxation: An inhibitory action on protein kinase C

General Pharmacology

Volumn 33, Issue 5, 1999, Pages 415-421

  Johns, Douglas G ^a   Jin, Jong Shiaw ^b   Wilde, Dixon W ^a   Webb, R Clinton ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Ceramide; Okadaic acid; Oleoylethanolamine; Sphingosine; Vascular smooth muscle; Vasorelaxation

Indexed keywords

CERAMIDE; CHELERYTHRINE; ETHANOLAMINE DERIVATIVE; OKADAIC ACID; PHORBOL ESTER; PHOSPHATASE; PROTEIN KINASE C; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THORACIC AORTA; VASCULAR SMOOTH MUSCLE; VASODILATATION;

AMIDOHYDROLASES; ANIMALS; AORTA, THORACIC; CERAMIDES; DRUG INTERACTIONS; ENZYME INHIBITORS; ETHANOLAMINES; MALE; MUSCLE, SMOOTH, VASCULAR; OKADAIC ACID; PHORBOLS; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; VASODILATION;

EID: 0032726839     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(99)00038-5     Document Type: Article

References (25)

1. Andreas J.E., Walsh M.P. Protein kinase C of smooth muscle. Hypertension. 20:1992;585-595.
2. Cohen P., Cohen P.T. Protein phosphatases come of age. J Biol Chem. 264:1989;21435-21438.
3. Damas P., Canivet J.-L., DeGroote D., Vrindts Y., Albert A., Franchimont P., Lamy M. Sepsis and serum cytokine concentrations. Crit Care Med. 25:1997;405-412.
4. Dobrowsky R.T., Kamibayashi C., Mumby M.C., Hannun Y.A. Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem. 268:1993;15523-15530.
5. Edmunds N.J., Woodward B. Effects of tumour necrosis factor-alpha on the coronary circulation of the rat isolated perfused heart. a potential role for thromboxane A2 and sphingosine Br J Pharmac. 124:1998;493-498.
6. Ertel W., Morrison M.H., Wang P., Bah Z.F., Ayala A., Chaudry I.H. The complex pattern of cytokines in sepsis. association between prostaglandins, cachectin, and interleukins Ann Surg. 214:1991;141-148.
7. Ferreri N.R., Zhao Y., Takizawa H., McGiff J.C. Tumor necrosis factor-alpha-angiotensin interactions and regulation of blood pressure. J Hypertens. 15:1997;1481-1484.
8. Fukami M., Tani E., Takai A., Yamaura I., Minami N. Activity of smooth muscle phosphatases 1 and 2A in rabbit basilar artery in vasospasm. Stroke. 26:1995;2321-2327.
9. 2+ indicators with greatly improved fluorescence properties. J Biol Chem. 260:1985;3440-3450.
10. Haller H., Smallwood J.I., Rasmussen H. Protein kinase C translocation in intact smooth muscle strips. Biochem J. 270:1990;375-381.
11. Hannun Y. The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem. 269:1994;3125-3128.
12. Hannun Y.A., Linardic C.A. Sphingolipid breakdown products. anti-proliferative and tumor-suppressor lipids Biochim Biophys Acta. 1154:1993;223-236.
13. Hannun Y.A., Loomis C.R., Merrill A.H. Jr., Bell R.M. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem. 261:1986;12604-12609.
14. 2-dependent ceramide signaling Am J Physiol. 275:1998;H1592-H1598.
15. Johns D.G., Osborn H.O., Webb R.C. Ceramide. a novel cell signaling mechanism for vasodilation Biochem Biophys Res Commun. 237:1997;95-97.
16. Jones M.J., Murray A.W. Evidence that ceramide selectively inhibits protein kinase C-α translocation and modulates bradykinin activation of phospholipase D. J Biol Chem. 266:1995;5007-5013.
17. Kim M.-Y., Linardic C., Obeid L., Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma interferon. specific role in cell differentiation J Biol Chem. 266:1991;484-489.
18. Lee J.Y., Hannun Y.A., Obeid L.M. Ceramide inactivates cellular protein kinase Cα J Biol Chem. 271:1996;13169-13174.
19. Murohara T., Kugiyama K., Ohgushi M., Sugiyama S., Ohta Y., Yasue H. Effects of sphingomyelinase and sphingosine on arterial vasomotor regulation. J Lipid Res. 37:1996;1601-1608.
20. i and contraction caused by phorbol esters in vascular smooth muscle cells. Am J Physiol. 265:1993;C1138-C1145.
21. Preiss J.E., Loomis C.R., Bell R.M., Niedel J.E. Quantitative measurement of sn-1,2-diacylglycerols. Methods Enzymol. 141:1987;294-300.
22. Redman C., Lefevre J., MacDonald M.L. Inhibition of diacylglycerol kinase by the antitumor agent calphostin C. evidence for the similarity between the active site of diacylglycerol kinase and the regulatory site of protein kinase C Biochem Pharmac. 50:1995;235-241.
23. Ridgeway N.D., Merriam D.L. Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells. Biochim Biophys Acta. 1256:1995;57-70.
24. Sugita M., Willians M., Dulaney J.T., Moser H.W. Ceramidase and ceramide synthesis in human kidney and cerebellum. description of a new alkaline ceramidase Biochim Biophys Acta. 398:1975;125-131.
25. Wiesner D.A., Dawson G. Programmed cell death in neurotumour cells involves the generation of ceramide. Glycoconjugate J. 13:1996;327-333.