Effects of endothelin antagonists on isolated perfused murine livers in the early phase of warm ischemia-reperfusion injury under propofol anesthesia

Japanese Journal of Anesthesiology

Volumn 48, Issue 10, 1999, Pages 1113-1120

  Tanaka, Ken ^a   Karasawa, Fujio ^a   Sato, Tetsuo ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BOSENTAN; ENDOTHELIN RECEPTOR ANTAGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; PERHYDRO 1 AZEPINYLCARBONYLLEUCYL DEXTRO TRYPTOPHYL DEXTRO TRYPTOPHAN; PROPOFOL; SOYBEAN OIL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ISOLATED LIVER; LIVER ISCHEMIA; LIVER PERFUSION; NONHUMAN; OXYGEN CONSUMPTION; PORTAL VEIN BLOOD PRESSURE; RAT; REPERFUSION INJURY;

ANESTHESIA, INTRAVENOUS; ANESTHETICS, INTRAVENOUS; ANIMALS; AZEPINES; DISEASE MODELS, ANIMAL; ENDOTHELINS; FREE RADICAL SCAVENGERS; LIVER; MALE; OLIGOPEPTIDES; PIPERIDINES; PROPOFOL; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SULFONAMIDES;

EID: 0032726344     PISSN: 00214892     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Vitola JV, Forman MB, Holsinger JP, et al: Role of endothelin in a rabbit model of acute myocardial infarction: Effects of receptor antagonists. J Cardiovasc Pharmacol 28: 774, 1996
2. Tanaka K, Karasawa F, Sato T: Effects of selective and non-selective endothelin antagonists on ischemia-reperfusion damage in isolated murine liver. Biochem Res Commun: (in press), 1999
3. 2 synthesis. Anesthesiology 90: 215, 1999
4. Wang HG, Shibamoto T, Miyahara T: Endothelin-1 selectively contracts portal vein through both ETA and ETB receptors in isolated rabbit liver. Am J Physiol 273: G 1036, 1997
5. Oshita M, Sato N, Yoshihara H, et al: Ethanolinduced vasoconstriction causes focal hepatocellular injury in the isolated perfused rat liver. Hepatology 16: 1007, 1994
6. Rockey DC: Characterization of endothelin receptors mediating rat hepatic stellate cell contraction. Biochem Biophys Res Commun 207: 725, 1995
7. Higuchi H, Sato T: Endothelin-1 induces vasoconstriction and nitric oxide release via endothelin ETB receptors in isolated perfused rat liver. Eur J Pharmacol 328: 175, 1997
8. Zhang JX, Bauer M, Clemens MG: Vessel- and target cell-specific actions of endothelin-1 and endothelin-3 in rat liver. Am J Physiol 269: G 269, 1995
9. Rigoulet M, Devin A, Averet N, et al: Mechanisms of inhibition and uncoupling of respiration in isolated rat liver mitochondria by the general anesthetic 2,6-diisopropylphenol. Eur J Biochem 241: 280, 1996
10. Murphy PG, Bennett JR, Myers DS, et al: The effect of propofol anesthesia on free radicalinduced lipid peroxidation in rat liver microsomes. Eur J Anaesthesiol 10: 261, 1993
11. Mittal MK, Gupta TK, Lee FY, et al: Nitric oxide modulates hepatic vascular tone in normal rat liver. Am J Physiol 267: G 416, 1994
12. Kon S, Imai M, Inaba H: Isoflurane attenuates early neutrophil-independent hypoxia-reoxygenation injuries in the reperfused liver in fasted rats. Anesthesiology 86: 128, 1997
13. Liu R, Lang MG, Luscher TF, et al: Propofol-induced relaxation of rat mesenteric arteries: Evidence for a cyclic GMP-mediated mechanism. J Cardiovasc Pharmacol 32: 709, 1998
14. Suematsu M, Goda N, Sano N, et al: Carbon monoxide: As an endogenous sinusoidal tone in the perfused rat liver. J Clin Invest 96: 2431, 1995
15. Pannen BH, Bauer M: Differential regulation of hepatic arterial and portal venous vascular resistance by nitric oxide and carbon monoxide in rats. Life Sci 62: 2025, 1998
16. Smith C, McEwan AI, Jhaveri R, et al: The interaction of fentanyl on the Cp 50 of propofol for loss of consciousness and skin incision. Anesthesiology 81: 820, 1994