The p27/Kip1 locus shows no loss of heterozygosity in human pituitary adenomas

Journal of Neuro-Oncology

Volumn 44, Issue 1, 1999, Pages 35-39

  Wilson, John C ^a   Zhu, Jay Jiguang ^a,b   Black, Peter McL ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Chromosome 12p; Cyclin dependent kinase inhibitors; Loss of heterozygosity; Microsatellite markers; p27 Kip1; Pituitary adenomas

Indexed keywords

PROTEIN P27;

ADULT; AGED; ARTICLE; CELL CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; MALE; POLYMERASE CHAIN REACTION; TRISOMY;

ADENOMA; ADULT; AGED; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; PITUITARY NEOPLASMS; TRISOMY; TUMOR SUPPRESSOR PROTEINS;

EID: 0032726277     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006242118541     Document Type: Article

References (30)

1. Thapar K, Kovacs K, Laws ER: Pituitary Tumors. In: Black, PM and Loeffler, JS (eds), Cancer of the Nervous System, pp 363-403. Cambridge: Blackwell Science, Inc., 1997
2. Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM: A syndrome of hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip 1)-deficient mice. Cell 85: 733-44, 1996
3. Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, Ono M, Khanam D, Hayday AC, Frohman LA, Koff A: Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kipl). Cell 85: 721-32, 1996
4. Nakayama K, Ishida N, Shirane, M, Inomata A, Inoue T, Shishido N, Horii I, Loh DY, Nakayama K: Mice lacking p27(Kipl) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85: 707-20, 1996
5. Firpo EJ, Koff A, Solomon MJ, Roberts JM: Inactivation of a Cdk2 inhibitor during interluekin 2-induced proliferation of human T lymphocytes. Mol Cell Biol 14: 4889-901, 1994
6. Hengst L, Dulic V, Slingerland JM, Lees E, Reed SI: A cell cycle-regulated inhibitor of cyclin-dependent kinases. Proc Natl Acad Sci USA 91: 5291-5, 1994
7. Polyak, K, Kato, JY, Solomon, MJ, Sherr, CJ, Massague, J, Roberts, Jm, Koff, A: p27Kipl, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 8: 9-22, 1994
8. Toyoshima H, Hunter T: p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78: 67-74, 1994
9. Kato JY, Matsuoka M, Polyak K, Massague J, Sherr CJ: Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. Cell 79: 487-96, 1994
10. Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee MH, Massague J, Crabtree GR, Roberts JM: Interleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570-3, 1994
11. Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massague J: Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78: 59-66, 1994
12. Qian X, Jin L, Grande JP, Lloyd RV: Transforming growth factor-beta and p27 expression in pituitary cells. Endocrinology 137: 3051-60, 1996
13. Reynisdottir I, Polyak K, lavarone A, Massague J: Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 9: 1831-45, 1995
14. Cave H, Gerard B, Martin E, Guidal C, Devaux I, Weissenbach J, Elion J, Vilmer E, Grandchamp B: Loss of heterozygosity in the chromosomal region 12p12-13 is very common in childhood acute lymphoblastic leukemia and permits the precise localization of a tumor suppressor gene distinct from p27KIP1. Blood 86, 3869-75, 1995
15. Ferrando AA, Balbin M, Pendas AM, Vizoso F, Velasco G, Lopez-Otin C: Mutational analysis of the human cyclin-dependent kinase inhibitor p27kip1 in primary breast carcinomas. Hum Genet 97: 91-4, 1996
16. Kawamata N, Morosetti R, Miller CW, Park D, Spirin KS, Nakamaki T, Takeuchi S, Hatta Y, Simpson J, Wilcyznski S, Lee YY, Bartram CR, Koeffler HP: Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies. Cancer Res 55: 2266-9, 1995
17. Kawamata N, Seriu T, Koeffler HP, Bartram CR: Molecular analysis of the cyclin-dependent kinase inhibitor family: p16(CDKN2/MTS/INK4A), p18(INK4C), and p27(Kip1) genes in neuroblastoma. Cancer 77: 570-5, 1996
18. Pietenpol JA, Bohlander SK, Sato Y, Papadopoulos N, Liu B, Friedman C, Trask BJ, Roberts JM, Kinzler KW, Rowley JD, Vogelstein B: Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. Cancer Res 55: 1206-10, 1995
19. Ponce-Castaneda MV, Lee MH, Latres E, Polyak K, Lacombe L, Montgomery K, Mathew S, Krauter K, Sheinfeld J, Massague J, Cordon-Cardo C: p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. Cancer Res 55: 1211-4, 1995
20. Spirin KS, Simpson JF, Takeuchi S, Kawamata N, Miller CW, Koeffler HP: p27/Kip1 mutation found in breast cancer. Cancer Res 56: 2400-4, 1996
21. Stegmaier K, Takeuchi S, Golub TR, Bohlander SK, Bartram CR, Koeffler HP: Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia. Cancer Res 56: 1413-7, 1996
22. Ikeda H, Yoshimoto T, Shida N: Molecular analysis of p21 and p27 genes in human pituitary adenomas. Br J Cancer 76: 1119-23, 1997
23. Tanaka C, Yoshimoto K, Yang P, Kimura T, Yamada S, Moritani M, Sano T, Itakura M: Infrequent mutations of p27Kip1 gene and trisomy 12 in a subset of human pituitary adenomas. J Clin Endocrinol Metab 82: 3141-7, 1997
24. Zhu J, Leon SP, Beggs AH, Busque L, Gilliland DG, Black PM: Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus. J Clin Endocrinol Metab 78: 922-7, 1994
25. Stegmaier K, Pendse S, Barker GF, Bray-Ward P, Ward DC, Montgomery KT, Krauter KS, Reynolds C, Sklar J, Donnelly M, Bohlander SK, Rowley JD, Sallan SE, Gilliland DG, Golub TR: Frequent loss of heterozygosity at the TEL locus in acute lymphoblastic leukemia of childhood. Blood 86: 38-44, 1995
26. Knudson AG, Jr: Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68: 820-3, 1971
27. Lloyd RV, Jin L, Qian X, Kulig E: Aberrant p27kip1 expression in endocrine and other tumors. Am J Pathol 150: 401-7, 1997
28. Jin L, Qian X, Kulig E, Sanno N, Scheithauer BW, Kovacs K, Young WF Jr, Lloyd RV: Transforming growth factor-beta, transforming growth factor-beta receptor II, and p27Kip1 expression in nontumorous and neoplastic human pituitaries. Am J Pathol 151: 509-19, 1997
29. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M: Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 (see comments). Science 269: 682-5, 1995
30. Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM, Pagano M: Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas (see comments). Nat Med 3:231-4, 1997