Experimental and theoretical comparisons between the classical Schild analysis and a new alternative method to evaluate the pA2 of competitive antagonists

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 360, Issue 5, 1999, Pages 477-487

  Calderone, Vincenzo ^a   Baragatti, Barbara ^b   Breschi, Maria Cristina ^b   Martinotti, Enrica ^b  

^a UNIVERSITY OF PISA   (Italy)

^b Universitadi Pisa   (Italy)

Author keywords

Antagonist dissociation constant; Competitive antagonism; PA2; Schild analysis

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ATROPINE; BETHANECHOL; CARBACHOL; CORBADRINE; DIBENAMINE; IDAZOXAN; NORADRENALIN; PIRENZEPINE;

ALGORITHM; ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG DETERMINATION; DRUG POTENCY; GUINEA PIG; INTERMETHOD COMPARISON; MALE; MATHEMATICAL COMPUTING; NONHUMAN; RAT;

ANIMALS; AORTA, THORACIC; ATRIAL FUNCTION; BINDING, COMPETITIVE; ELECTRIC STIMULATION; GASTRIC FUNDUS; GUINEA PIGS; HEART ATRIA; ILEUM; MALE; MODELS, BIOLOGICAL; MUSCLE, SMOOTH; PHARMACEUTICAL PREPARATIONS; PHARMACOLOGY; RATS; RATS, WISTAR; RECEPTORS, DRUG; REGRESSION ANALYSIS;

EID: 0032725897     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900082     Document Type: Article

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