Altered baroreflex control of heart rate in bradykinin B2-receptor knockout mice

Immunopharmacology

Volumn 45, Issue 1-3, 1999, Pages 21-27

  Madeddu, Paolo ^a,b,c   Bonaria Salis, Maria ^a,b   Emanueli, Costanza ^a,b  

^a National Laboratory   (Italy)

^b Laboratory of Vascular Pathology   (Italy)

^c UNIVERSITY OF SASSARI   (Italy)

Author keywords

Angiotensin; Blood pressure; Bradykinin; Genes; Heart rate

Indexed keywords

ANGIOTENSIN; BRADYKININ; BRADYKININ B2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; HEART RATE; HYPERTENSION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANESTHETICS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTIHYPERTENSIVE AGENTS; AUTONOMIC NERVE BLOCK; BAROREFLEX; BLOOD PRESSURE; GANGLIONIC BLOCKERS; HEART RATE; MALE; MICE; MICE, KNOCKOUT; NICOTINIC ACIDS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTOR, BRADYKININ B2; RECEPTORS, ANGIOTENSIN; RECEPTORS, BRADYKININ; TETRAZOLES;

EID: 0032725443     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(99)00053-3     Document Type: Article

References (21)

1. Berry T.D., Hasstedt S.J., Hunt S.C., Wu L.L., Smith J.B., Ash K.O., Kuida H., Williams R.R. A gene for high kallikrein may protect against hypertension in Huta kindreds. Hypertension. 13:1989;3-8.
2. 2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J. Biol. Chem. 23:1995;13706-13710.
3. Caligiorne S.M., Santos R.A., Campagnole-Santos M.J. Cardiovascular effects produced by bradykinin microinjection into the nucleus tractus solitarii of anesthetized rats. Brain Res. 720:1996;183-190.
4. 2 receptor gene. 52nd Council for High Blood Pressure Research, Abs P165.
5. Fleming I., Busse R. Tyrosine phosphorylation and bradykinin-induced signaling in endothelial calls. Am. J. Cardiol. 80(3A):1997;102A-109A.
6. Julius S., Jamerson K., Mejia A., Krause L., Schork N., Jones K. The association of borderline hypertension with target organ changes and higher coronary risk: Tecumseh Blood Pressure Study. JAMA. 264:1990;354-358.
7. Kannel W.B., Kannel C., Paffenbarger R.S. Jr., Cupples L.A. Heart rate and cardiovascular mortality: the Framingham study. Am. Heart J. 113:1987;1489-1494.
8. Linz W., Wieimer G., Gholke P., Unger T., Scholkens B.A. Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors. Pharmacol. Rev. 47(1):1995;25-49.
9. 2-receptor gene. Circulation. 96:1997;3570-3578.
10. 2-receptors alters the adult cardiovascular phenotype in rats. Hypertension. 25:1995;453-459.
11. Madeddu P., Glorioso N., Varoni M.V., Demontis M.P., Fattaccio M.C., Anania V. Cardiovascular effects of brain kinin receptor blockade in spontaneously hypertensive rats. Hypertension. 23(1):1994;I189-I192. Suppl.
12. Palatini P., Casiglia E., Pauletto P., Staessen J., Kacirotti N., Julius S. Relationship of tachycardia with high blood pressure and metabolic abnormalities. A study with mixture analysis in three populations. Hypertension. 30:1997;1267-1273.
13. Pravanec M., Kren V., Kunes J., Scicli A.G., Carretero O.A., Simonet L., Kurtz T.W. Cosegregation of blood pressure with a kallikrein gene family polymorphism. Hypertension. 17:1991;242-246.
14. Rajiani H.Y., Bolla B.S., de Guzman F.Q. Attenuation of epinephrine-induced dysrhythmias by bradykinin: role of nitric oxide and prostaglandins. Am. J. Cardiol. 80(3A):1997;153A-157A.
15. 2-receptor antagonists. Hypertension. 17:1991;107-115.
16. Schultz H.D., Wang W., Ustinova E.E., Zucker I.H. Enhanced responsiveness of cardiac vagal chemosensitive endings to bradykinin in heart failure. Am. J. Physiol. 273:1997;R637-R645.
17. 2-receptor activation augments norepinephrine exocytosis from cardiac sympathetic nerve endings. Mediation by autocrine/paracrine mechanisms. Circ. Res. 81:1997;774-784.
18. sα. Circ. Res. 82:1998;416-423.
19. Wang C., Chao C., Madeddu P., Chao L., Chao J. Central delivery of human tissue kallikrein gene reduces blood pressure in hypertensive rats. Biochem. Biophys. Res. Commun. 17:1998;449-454.
20. Wiesel P., Mazzolai L., Nussberger J., Pedrazzini T. Two-kidney, one clip and one-kidney, one clip hypertension in mice. Hypertension. 29:1997;1025-1030.
21. Yayama K., Wang C., Chao L., Chao J. Kallikrein gene delivery attenuates hypertension and cardiac hypertrophy and enhances renal function in Goldblatt hypertensive rats. Hypertension. 31:1998;1104-1110.