Evaluation of the reverse transcriptase/polymerase chain reaction for carcinoembryonic antigen for the detection of breast cancer dissemination in bone marrow and peripheral blood

Journal of Cancer Research and Clinical Oncology

Volumn 125, Issue 12, 1999, Pages 669-674

  Zhong, Xiao Yan ^a,b   Kaul, Sepp ^a   Thompson, John ^c   Eichler, Astrid ^a   Bastert, Gunther ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

^c NONE

Author keywords

Breast cancer; CEA; Metastasis; RT PCR

Indexed keywords

CARCINOEMBRYONIC ANTIGEN;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BLOOD; BONE MARROW; BREAST CANCER; CANCER CELL CULTURE; CELL HETEROGENEITY; CONTROLLED STUDY; DISEASE MARKER; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BONE MARROW; BREAST NEOPLASMS; CARCINOEMBRYONIC ANTIGEN; EVALUATION STUDIES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0032725426     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050332     Document Type: Article

References (23)

1. Burchill SA, Bradbury FM, Pittman K, Southgate J, Smith B, Selby P (1994) Detection of epithelial cancer cells in peripheral blood by reverse transcriptase polymerase chain reaction. Br J Cancer 71:278-281
2. Datta YH, Adams PT, Drobyski WR, Ethier SP, Terry VH, Roth MS (1994) Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction. J Clin Oncol 12:475-482
3. Diel IJ, Kaufmann M, Goerner R, Costa SD, Kaul S, Bastert G (1992) Detection of tumour cells in bone marrow of patients with primary breast cancer: a prognostic factor for distant metastasis. J Clin Oncol 10:1534-1539
4. Esteban JM, Felder B, Ahn C, Simpson JF, Battifora H, Shively JE (1994) Prognostic relevance of carcinoembryonic antigen and estrogen receptor status in breast cancer patients. Cancer 74:1575-1583
5. Gerhard M, Juhl H, Kalthoff H, Schreiber HW, Wagener C, Neumaier M (1994) Specific detection of carcinoembryonic antigen-expressing tumour cells in bone marrow aspirates by polymerase chain reaction. J Clin Oncol 12:725-729
6. Graaf DH, Mælandsmo GM, Ruun P, Forus A, Øyjord T, Fodstad Ø, Hovig E (1997) Ectopic Expression of target genes may represent an inherent limitation of RT-PCR assays used for micrometastasis detection: studies on the epithelial glycoprotein gene EGP-2. Int J Cancer 72:191-196
7. Israeli RS, Miller WH Jr, Su SL, Powell CT, Fair WR, Samedi DS, Huryk RE, De Blasio A, Edwards ET, Wise GJ, Heston WDW (1994) Sensitive nested reverse transcription polymerase chain reaction detection of circulating prostatic tumour cells: comparison of prostate-specific membrane antigen and prostate-specific antigen-based assays. Cancer Res 54:6306-6310
8. Kaul S, Zhong XY, Diel I, Bastert G (1996) Tumour cell contamination (TC) in bone marrow of breast cancer patients: Improved sensitivity and quantification of tumour cells using BM2-immunomagnetic beads. Arch Gynecol Obstet 258:192
9. Krismann M, Todt B, Schröder J, Gareis D, Müller KM, Seeber S, Schütte J (1995) Low specificity of cytokeratin 19 reverse transcriptase-polymerase chain reaction analyses for detection of hematogenous lung cancer dissemination. J Clin Oncol 13:2769-2775
10. Lucas K, Busch M, Mössinger S, Thompson JA (1991) An improved microcomputer program for finding gene- or gene family-specific oligonucleotides suitable as primers for polymerase chain reactions or as probes. Comput Appl Biosci 7:525-529
11. Mori M, Mimori K, Inoue H, Barbard GF, Tsuji K, Nnanbara S, Ueo H, Akiyoshi T (1995) Detection of cancer micrometastases in lymph nodes by reverse transcriptase-polymerase chain reaction. Cancer Res 55:3417-3420
12. Moss T, Pantel K, Bik T (1994) Evaluation of grafts for occult tumor cells (editorial). J Hematother 3:163-164
13. Neumaier M (1993) Chimeric CEA-specific antibody fragments and anti-idiotypic antibodies for immunoscintigraphy and new therapeutic approaches to colorectal carcinomas. In: Wagener C, Neumann S (eds) Molecular diagnostics of cancer. Springer, Berlin Heidelberg New York, pp 187-206
14. Pantel K, Schlimok G, Angstwurm M, Weckermann C, Schmaus W, Gath H, Passlick B, Izbicki J, Riethmüller G (1994) Methodological analysis of immunocytochemical screening for disseminated epithelial tumour cells in bone marrow. J Hematother 3:165-173
15. Redding WH, Coombes RC, Monaghan P, Clink HM, Imrie SF, Dearnales DP, Ormerod MG, Sloane JP, Gazet JC, Powles TJ, Neville AM (1983) Detection of micrometastases in patients with primary breast cancer. Lancet 2:1271-1274
16. Schrewe H, Thompson J, Bona M, Hefta LJ, Maruya A, Hassauer M, Shively JE, Von Kleist S, Zimmermann W (1990) Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression. Mol Cell Biol 7:2738-2748
17. Shively JE, Beatty JD (1985) CEA-related antigens: molecular biology and clinical significance. Crit Rev Oncol Hematol 2:355-399
18. Teglund S, Olsen A, Khan WN, Frangsmyr L, Hammarstron S (1994) The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA). Genomics 23:669-684
19. Thompson J (1995) Molecular cloning and expression of carcinoembryonic antigen gene family members. Turnout Biol 16:10-16
20. Traweek S, Liu J, Battifora H (1993) Keratin expression in non-epithelial tissues. Am J Pathol 142:1111-1119
21. Zhong XY, Kaul S, Diel I, Bastert G (1996) Tumour cell contamination (TC) in bone marrow of breast cancer patients: sensitive detection by reverse transcriptase-polymerase chain reactions for MUC1, CEA, keratin 19 and GA733-2. Arch Gynecol Obstet 258:92
22. Zhong XY, Kaul S, Eichler A, Bastert G (1998) Low specificity of MUC1 as a marker to detect epithelial cancer dissemination in human bone marrow and blood. Clin Lab 44:971-978
23. Zhong YX, Kaul S, Eichner A, Diel I, Bastert G (1999) Sensitivity and specificity of immunocytochemistry for the detection of tumor cells in the bone marrow of patients with breast cancer. Tumor Diagn 20:39-44