A novel, non-nested reverse-transcriptase polymerase chain reaction (RT- PCR) test for the detection of the t(15;17) translocation: A comparative study of RT-PCR cytogenetics, and fluorescence in situ hybridization

Molecular Diagnosis

Volumn 4, Issue 3, 1999, Pages 195-209

  Rennert, Hanna ^a   Golde, Todd ^b   Wilson, Robert B ^a   Spitalnik, Stephen L ^c   van Deerlin, Vivianna M D ^a   Leonard, Debra G B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Acute promyelocytic leukemia; All trans retinoic acid; Minimal residual disease; Polymerase chain reaction; Retinoic acid receptor; Reverse transcription

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; RETINOIC ACID; RETINOIC ACID RECEPTOR;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CONTROLLED STUDY; CYTOGENETICS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0032724514     PISSN: 10848592     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1084-8592(99)80023-X     Document Type: Article

References (4)

1. Lavau C, Dejean A: The t(15;17) translocation in acute promylocytic leukemia. Leukemia 1994;8: 1615-1621
2. Grignani F, Fagioli M, Alcalay M, Longo L, Pandolpi PP, Donti E, et al: Acute promyelocytic leukemia: From genetics to treatment. Blood 1994;83:10-25
3. Kakizuka KA, Miller WH Jr, Umesono K, Warfell RP Jr, Frankel SR, Murthy VVVS, et al: Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell 1991;66:663-673
4. Goddard AD, Borrow J, Freemont PS, Solomon E: Characterization of a zinc finger gene disrupted by the t(15;17) in APL. Science 1991;254:1371-1374