Replacement of Phe8 in substance P by Tyr (Tyr8-SP) alters the conformation of the peptide in DMSO, water, and lipid bilayers

Biopolymers

Volumn 50, Issue 6, 1999, Pages 602-612

  Patel, Anant B ^a   Srivastava, Sudha ^a   Coutinho, Evans ^b   Phadke, Ratna S ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b BOMBAY COLLEGE OF PHARMACY   (India)

Author keywords

Lipid bilayers; Molecular dynamics; nmr; Peptide conformation; Tyr8 SP

Indexed keywords

COMPUTER SIMULATION; CONFORMATIONS; LIPIDS; MATHEMATICAL MODELS; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHASE TRANSITIONS; STRUCTURE (COMPOSITION); WATER;

DIMETHYLSULFOXIDE; DIPALMITOYL PHOSPHATIDYLCHOLINE; NEUROKININ TACHYKININ RECEPTOR; OVERHAUSER EFFECTS;

BIOPOLYMERS;

DIMETHYL SULFOXIDE; DIPALMITOYLPHOSPHATIDYLCHOLINE; PHENYLALANINE; SUBSTANCE P; TYROSINE; WATER;

ARTICLE; CONFORMATIONAL TRANSITION; LIPID BILAYER; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; DIMETHYL SULFOXIDE; LIPID BILAYERS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECEPTORS, NEUROKININ-1; SUBSTANCE P; THERMODYNAMICS; WATER;

EID: 0032722755     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(199911)50:6<602::AID-BIP5>3.0.CO;2-N     Document Type: Article

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