Decrease in N-acetylaspartate without commensurate accumulation of acetate in focal cerebral ischemia in rat

Neurological Research

Volumn 21, Issue 8, 1999, Pages 771-774

  Nonaka, Masahiro ^a   Yoshimine, Toshiki ^a   Kumura, Eiji ^a   Kohmura, Eiji ^a   Wakayama, Akatsuki ^a   Hayakawa, Toru ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Acetate; Aspartate; Cerebral ischemia; N acetylaspartate; Proton nuclear magnetic resonance spectroscopy

Indexed keywords

ACETIC ACID; ASPARTIC ACID; N ACETYLASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DECAPITATION; HYDROLYSIS; MALE; METABOLITE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 0032722163     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1080/01616412.1999.11741012     Document Type: Article

References (17)

1. Urenjak J, Williams SR, Gadian DG, Noble M. Specific expression of N-acetyl-aspartate in neurons oligodendrocyte-type 2 astrocyte progenitors and immature oligodendrocytes in vitro. J Neurochem 1992; 59: 55-61
2. Urenjak J, Williams SR, Gadian DG, Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 1993; 13: 981-989
3. Morffett JR, Namboodiri MA, Neale JH. Enhanced carbodiimide fixation for immunohistochemistry: Application to the comparative distributions of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat brain. J Hist Cyt 1993; 41: 559-570
4. D'Adamo AF, Yatsu FM. Acetate metabolism in the nervous system N-acetyl-L-aspartic acid and the biosynthesis of brain lipids. J Neurochem 1973; 13: 961-965
5. 1H-magnetic resonance spectroscopic imaging. J Cereb Blood Flow Metab 1994; 14: 373-382
6. 1H-NMR spectroscopic studies of the brain. Neurosci Biobehav Rev 1989; 13: 23-31
7. 1H magnetic resonance spectroscopy in rats. Neurosurgery 1996; 38: 121-130
8. Tsai G, Coyle JT. N-acetylaspartate in neuropsychiatric disorders. Prog Neurobiol 1995; 46: 531-540
9. 1H NMR spectroscopy following experimental brain trauma. J Neurotrauma 1997; 14: 441-449
10. Sager TN, Laursen H, Hansen AJ. Changes in N-acetyl-aspartate content during focal and global brain ischemia of the rat. J Cereb Blood Flow Metab 1995; 15: 639-646
11. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G. Experimental studies of ischemic brain edema: 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke 1986; 20: 1-8
12. Peeling J, Wong D, Sutherland GR. Nuclear magnetic resonance study of regional metabolism after forebrain ischemia in rats. Stroke 1989; 20: 633-640
13. Nonaka M, Yoshimine T, Kohmura E, Wakayama A, Yamashita T, Hayakawa T. Changes in brain organic osmolytes in experimental cerebral ischemia. J Neurol Sci 1998; 157: 25-30
14. Matsumoto K, Graf R, Rosner G, Taguchi J, Heiss WD. Elevation of neuroactive substances in the cortex of cats during prolonged focal ischemia. J Cereb Blood Flow Metab 1993; 13: 586-594
15. Shimada N, Graf R, Rosner G, Heiss WD. Ischemia-induced accumulation of extracellular amino acids in cerebral cortex white matter and cerebrospinal fluid. J Neurochem 1993; 60: 66-71
16. Sager TN, Fink-Jensen A, Hansen AJ. Transient elevation of interstitial N-acetyl aspartate in reversible global brain ischemia. J Neurochem 1997; 68: 675-682
17. Menzies SA, Betz AL, Hoff JT. Contributions of ions and albumin to the formation and resolution of ischemic brain edema. J Neurosurg 1993; 78: 257-266