The presence of lead decreases the availability of meso-2,3- dimercaptosuccinic acid for analysis in the monobromobimane assay

Chemical Research in Toxicology

Volumn 12, Issue 11, 1999, Pages 1057-1065

  Lever, Susan Z ^a,b   Parsons, Teresa L ^a  

^a Johns Hopkins University   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOBIMANE; CHELATING AGENT; DITHIOTHREITOL; EDETIC ACID; LEAD; LEAD 203; SUCCIMER;

ARTICLE; CHELATION; COMPLEX FORMATION; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEAD POISONING; QUANTITATIVE ASSAY; URINARY EXCRETION;

BICYCLO COMPOUNDS; CHELATING AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITHIOTHREITOL; EDETIC ACID; LEAD; ORGANOMETALLIC COMPOUNDS; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; SUCCIMER; SULFHYDRYL COMPOUNDS; SULFHYDRYL REAGENTS;

EID: 0032721570     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx980247y     Document Type: Article

References (31)

1. Chisolm, J. J., Jr. (1990) Evaluation of the potential role of chelation therapy in treatment of low to moderate lead exposures. Environ. Health Perspect. 89, 67-74.
2. Chisolm, J. J., Jr. (1992) BAL, EDTA, DMSA and DMPS in the treatment of lead poisoning in children. Clin. Toxicol. 30, 493-504.
3. Angle, C. R. (1993) Childhood lead poisoning and its treatment. Annu. Rev. Pharmacol. Toxicol. 33, 409-434.
4. Mortensen, M. E., and Walson, P. D. (1993) Chelation therapy for childhood lead poisoning. The changing scene in the 1990s. Clin. Pediatr. (Philadelphia) 32, 284-291.
5. Piomelli, S. (1994) Childhood lead poisoning in the 90s. Pediatrics 93, 508-510.
6. Centers for Disease Control (1991) Preventing lead poisoning in young children, Atlanta, GA.
7. Graziano, J. H., Lolacono, N. J., Moulton, T., Mitchell, M. E., Slavkovich, V., and Zarate, C. (1992) Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication. J. Pediatr. 120, 133-139.
8. Graziano, J. H. (1993) Conceptual and practical advances in the measurement and clinical management of lead toxicity. Neurotoxicology 14, 219-223.
9. Jones, M. M. (1983) Therapeutic chelating agents. In Metal Ions in Biological Systems (Sigel, H., Ed.) Vol. 16, pp 47-83, Marcel Dekker, New York.
10. Maiorino, R. M., Barry, T. J., and Aposhian, H. V. (1987) Determination and Metabolism of Dithiol Chelating Agents: Electrolytic and Chemical Reduction of Oxidized Dithiols in Urine. Anal. Biochem. 160, 217-226.
11. Maiorino, R. M., and Aposhian, H. V. (1989) Determination and metabolism of dithiol chelating agents. IV. Urinary excretion of meso-2,3-dimercaptosuccinic acid and mercaptosuccinic acid in rabbits given meso-2,3-dimercaptosuccinic acid. Biochem. Pharmacol. 38, 1147-1154.
12. Maiorino, R. M., Bruce, D. C., and Aposhian, H. V. (1989) Determination and metabolism of dithiol-chelating agents: VI. Isolation and identification of the mixed disulfides of meso-2,3-dimercaptosuccinic acid with L-cysteine in human urine. Toxicol. Appl. Pharmacol. 97, 338-349.
13. Maiorino, R. M., Akins, J. M., Blaha, K., Carter, D. E., and Aposhian, H. V. (1990) Determination and Metabolism of Dithiol Chelating Agents. X. In Humans meso-2,3-Dimercaptosuccinic Acid is Bound to Plasma Proteins via Mixed Disulfide Formation. J. Pharmacol. Exp. Ther. 254, 570-577.
14. Maiorino, R. M., Aposhian, M. M., Xu, Z. F., Li, Y. S., Polt, R. L., and Aposhian, H. V. (1993) Determination and metabolism of dithiol chelating agents. XV. the meso-2,3-dimercaptosuccinic acid cysteine (1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat. J. Pharmacol. Exp. Ther. 267, 1221-1226.
15. Kosower, N. S., Kosower, E. M., Newton, G. L., and Ranney, H. M. (1979) Bimane fluorescent labels: labeling of normal human red cells under physiological conditions. Proc. Natl. Acad. Sci. U.S.A. 76, 3382-3386.
16. Kosower, E. M., Pazhenchevsky, B., and Hershkowitz, E. (1978) 1,5-Diazabicyclo[3.3.0]octadienediones (9,10-Dioxabimanes). Strongly fluorescent syn-isomers. J. Am. Chem. Soc. 100, 6516-6518.
17. Aposhian, H. V., Maiorino, R. M., Dart, R. C., and Ferry, D. F. (1989) Urinary excretion of meso-2,3-dimercaptosuccinic acid in human subjects. Clin. Pharmacol. Ther. 254, 570-577.
18. Aposhian, H. V., Maiorino, R. M., Rivera, M., Bruce, D. C., Dart, R. C., Hurlbut, K. M., Levine, D. J., Zheng, W., Fernando, Q., Carter, D., and Aposhian, M. M. (1992) Human studies with the chelating agents, DMPS and DMSA. Clin. Toxicol. 30, 505-528.
19. Dart, R. C., Hurlbut, K. M., Maiorino, R. M., Mayersohn, M., Aposhian, H. V., and Hassen, L. (1994) Pharmacokinetics of meso-2,3-dimercaptosuccinic acid in patients with lead poisoning and in healthy adults. J. Pediatr. 125, 309-316.
20. Asiedu, P., Moulton, T., Blum, C. B., Roldan, E., Lolacono, N. J., and Graziano, J. H. (1995) Metabolism of meso-2,3-dimercaptosuccinic acid in lead-poisoned children and normal adults. Environ. Health Perspect. 103, 734-739.
21. Asiedu, P. (1994) Pharmacokinetics and Metabolism of Meso-2,3-Dimercaptosuccinic (DMSA) in Humans. Ph.D. Thesis, Columbia University, New York.
22. Rivera, M., Aposhian, H. V., and Fernando, Q. (1989) Lead chelates of meso- and racemic-dimercaptosuccinic acid. J. Inorg. Biochem. 37, 283-293.
23. Rivera, M., Zheng, W., Aposhian, H. V., and Fernando, Q. (1989) Determination and metabolism of dithiol chelating agents. VIII. Metal complexes of meso-dimercaptosuccinic acid. Toxicol. Appl. Pharmacol. 100, 96-106.
24. Fang, X., and Fernando, Q. (1995) Stereoisomeric selectivity of 2,3-dimercaptosuccinic acids in chelation therapy for lead poisoning. Chem. Res. Toxicol. 8, 525-536.
25. Harris, W. R., Chen, Y., Stenback, J., and Shah, B. (1991) Stability constants for dimercaptosuccinic acid with Bismuth(III), Zinc(II), and Lead(II). J. Coord. Chem. 23, 173-186.
26. Aposhian, H. V., Maiorino, R. M., Gonzalezramirez, D., Zunigacharles, M., Xu, Z. F., Hurlbut, K. M., Juncomunoz, P., Dart, R. C., and Aposhian, M. M. (1995) Mobilization of heavy metals by newer, therapeutically useful chelating agents. Toxicology 97, 23-38.
27. Aposhian, H. V., Maiorino, R. M., Dart, R. C., and Perry, D. F. (1989) Clin. Pharmacol. Ther. 45, 520-526.
28. Ramsey, D. T., Casteel, S. W., Faggella, A. M., Chastain, C. B., Nunn, J. W., and Schaeffer, D. J. (1996) J. Am. Vet. Med. Assoc. 208, 371-375.
29. Graziano, J. H., Lolacono, N. J., Moulton, T., Mitchell, M. E., Slavkovich, V., and Zarate, C. (1992) Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication. J. Pediatr. 120, 133-139.
30. Lee, B.-K., Schwartz, B. S., Stewart, W., and Ahn, K.-D. (1995) Provocative chelation with DMSA and EDTA: evidence for differential access to lead storage sites. Occup. Environ. Med. 52, 13-19.
31. Bergdahl, I. A., Vahter, M., Counter, S. A., Schutz, A., Buchanan, L. H., Ortega, F., Laurell, G., and Skerfving, S. (1999). Lead in plasma and whole blood from lead-exposed children. Environ. Res. 80, 25-33.