Role of p52 (NF-κB2) in LPS tolerance in a human B cell line

Biological Chemistry

Volumn 380, Issue 10, 1999, Pages 1193-1199

  Wedel, Angela ^a   Frankenberger, Marion ^a   Sulski, Gabi ^a   Petersmann, Irmhild ^a   Kuprash, Dmitry ^b   Nedospasov, Sergei ^c   Ziegler Heitbrock, H W Loems ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b SAIC FREDERICK INC   (United States)

^c ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

Endotoxin; Lipopolysaccharide; NF kappaB; Tolerance

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUCIFERASE;

ARTICLE; B LYMPHOCYTE; CELL LINE; CYTOSOL; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REPORTER GENE; TRANSACTIVATION; WESTERN BLOTTING;

ANTIGENS, CD14; B-LYMPHOCYTES; CELL LINE; CELL NUCLEUS; CYTOSOL; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LIPOPOLYSACCHARIDES; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EUKARYOTA;

EID: 0032721191     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.1999.151     Document Type: Article

References (52)

1. Beeson, P.B. (1947). Tolerance to bacterial pyrogens. I. Factors influencing its development. J. Exp. Med. 86, 29-44.
2. Bohuslav, J., Kravchenko, V.V., Parry, G.C., Erlich, J.H., Gerondakis, S., Macklman, N., and Ulevitch, R.C. (1998). Regulation of an essential innate immune response by the p50 subunit of F-kappaB. J. Clin. Invest. 102, 1645-1652.
3. Cavaillon, J.-M. (1995). The nonspecific nature of endotoxin tolerance. Trends Microbiol. 3, 320-324.
4. Coffee, K.A., Halushka, P.V., Ashton, S.H., Tempel, G.E., Wise, W.C., and Cook, J.A. (1992). Endotoxin tolerance is associated with altered GTP-binding protein function. J. Appl. Physiol. 73, 1008-1013.
5. Dignam, J.D., Lebovitz, R.M., and Roeder, R.G. (1983). Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489.
6. Dobrzanski, P., Ryseck, R.-P., and Bravo, R. (1995). Specific inhibition of RelB/p52 transcriptional activity by the C-terminal domain of p100. Oncogene 10, 1003-1007.
7. Frankenberger, M., Pechumer, H., and Ziegler-Heitbrock, H.W.L. (1995). Interleukin-10 is upregulated in LPS tolerance. J. Inflammation 45, 56-63.
8. Frankenberger, M., and Ziegler-Heitbrock, H.W.L. (1997). LPS Tolerance in monocyte/macrophages: Three 3′ Cytosins are required in the DNA binding motif for detection of upregulated NF-κB p50 homodimers. Immunobiol. 198, 81-90.
9. Franzoso, G., Bours, V., Park, S., Tomita-Yamaguchi, M., Kelly, K., and Siebenlist, U. (1992). The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition. Nature 359, 339-342.
10. Freudenberg, M.A., and Galanos, C. (1988). Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages. Infect. Immun. 56, 1352-1357.
11. Frey, E.A., Miller, D.S., Jahr, T.G., Sundan, A., Bazil, V., Espevik, T., Finlay, B.B., and Wright, S.D. (1992). Soluble CD14 participates in the response of cells to lipopolysaccharide. J. Exp. Med. 176, 1665-1671.
12. Goldfeld, A.E., and Maniatis, T. (1989). Coordinate viral induction of tumor necrosis factor alpha and interferon beta in human B cells and monocytes. Proc. Natl. Acad. Sci. USA 86, 1490-1494.
13. Greisman, S.E., Young, E.J., and Woodward, W.E. (1966). Mechanisms of endotoxin tolerance. IV. Specificity of the pyrogenic refractory state during continuous intravenous infusions of endotoxin. J. Exp. Med. 124, 983-1000.
14. Haas, J.G., Thiel, C., Blömer, K., Weiss, E.H., Riethmüller, G., and Ziegler-Heitbrock, H.W.L. (1989). Downregulation of tumor necrosis factor expression in the human Mono Mac 6 cell line by lipopolysaccharide. J. Leukocyte Biol. 46, 11-14.
15. Kastenbauer, S., Wedel, A., Frankenberger, M., Wirth, T., and Ziegler-Heitbrock, H.W.L. (1996). Analysis of promoter activity by polymerase chain reaction amplification of reporter gene mRNA. Anal. Biochem. 233, 137-139.
16. Kastenbauer, S., and Ziegler-Heitbrock, H.W. (1999). NF-kappaB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression. Infect. Immun. 67, 1553-1559.
17. Kieran, M., Blank, V., Logeat, F., Vandekerckhove, J., Lottspeich, F., Le Bail, O., Urban, M.B., Kourilsky, P., Baeuerle, P.A., and Israël, A. (1990). The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product. Cell 62, 1007-1018.
18. Kirschning, C.J., Wesche, H., Merrill Ayres, T., and Rothe, M. (1998). Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 188, 2091-2097.
19. Knopf, H.P., Otto, F., Engelhardt, R., Freudenberg, M.A., Galanos, C., Herrmann, F., and Schumann, R.R. (1994). Discordant adaptation of human peritoneal macrophages to stimulation by lipopolysaccharide and the synthetic lipid A analogue SDZ MRL953. J. Immunol. 153, 287-299.
20. Kravchenko, V.V., Steinemann, S., Kline, L., Feng, L., and Ulevitch, R.J. (1996). Endotoxin tolerance is induced in Chinese Hamster ovary cell lines expressing human CD14. Shock 5, 194-201.
21. Kunsch, C., Ruben, S.M., and Rosen, C.A. (1992). Selection of optimal κB/Rel DNA-binding motifs: interaction of both subunits of NF-κB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12, 4412-4421.
22. Labeta, M.O., Landmann, R., Obrecht, J.P., and Obrist, R. (1991). Human B cells express membrane-bound and soluble forms of the CD14 myeloid antigen. Mol. Immunol. 28, 115-122.
23. Lægreid, A., Thommesen, L., Gullstein Jahr, T., Sundan, A., and Espevik, T. (1995). Tumor necrosis factor induces lipopolysaccharide tolerance in a human adenocarcinoma cell line mainly through the TNF p55 receptor. J. Biol. Chem. 270, 25418-25425.
24. Marchant, A., Gueydan, C., Houzet, L., Amraoui, Z., Sels, A., Huez, G., Goldman, M., and Kruys, V. (1996). Defective translation of tumor necrosis factor mRNA in lipopolysaccharide-tolerant macrophages. J. Inflamm. 46, 114-123.
25. Mathison, J., Wolfson, E., Steinemann, S., Tobias, P., and Ulevitch, R. (1993). Lipopolysaccharide (LPS) recognition in macrophages. J. Clin. Invest. 92, 2053-2059.
26. Matsuoka, Y., Moore, G.E., Yagi, Y., and Pressman, D. (1967). Production of free light chains of immunoglobulin by a hematopoietic cell line derived from a patient with multiple myeloma. Proc. Soc. Exp. Biol. Med. 125, 1246-1250.
27. Medeiros, L.J., Herrington, R.D., Gonzalez, C.L., Jaffe, E.S., and Cossman, J. (1991). My4 antibody staining of non-Hodgkin's lymphomas. Am. J. Clin. Pathol. 95, 363-368.
28. Morabito, F., Prasthofer, E.F., Dunlap, N.E., Grossi, C.E., and Tilden, A.B. (1987). Expression of myelomonocytic antigens on chronic lymphocytic leukemia B cells correlates with their ability to produce interleukin-1. Blood 70, 1750-1757.
29. Plaksin, D., Bäuerle, P.A., and Eisenbach, L. (1993). KBF1 (p50 NF-κB homodimer) acts as a represser of H-2Kb gene expression in metastatic tumor cells. J. Exp. Med. 127, 1651-1662.
30. Poltorak, A., He, X., Smirnova, I., Liu, M.Y., Huffel, C.V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., and Beutler, B. (1998). Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088.
31. Pugin, J., Schürer-Maly, C.-C., Leturcq, D., Moriarty, A., Ulevitch, R.J., and Tobias, P.S. (1993). Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc. Natl. Acad. Sci. USA 90, 2744-2748.
32. Randow, F., Syrbe, U., Meisel, C., Krausch, D., Zuckermann, H., Platzer, C., and Volk, H.-D. (1995). Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor β. J. Exp. Med. 181, 1887-1892.
33. Schmitz, M.L., and Bäuerle, P.A. (1991). The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J. 10, 3805-3817.
34. Shakhov, A.N., Collart, M.A., Vassalli, P., Nedospasov, S.A., and Jongeneel, C.V. (1990). κB-type enhancers are involved in LPS-mediated transcriptional activation of the TNF-α gene in primary macrophages. J. Exp. Med. 171, 35-47.
35. + T cells express perturbed AP-1 and NF-κB transcription factors. Proc. Natl. Acad. Sci. USA 93, 979-984.
36. Sung, S.S., Jung, L.K., Walters, J.A., Cheng, W., Wang, C.Y., and Fu, S.M. (1988). Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells. J. Exp. Med. 168, 1539-1551.
37. Takasuka, N., Matsuura, K., Yamamoto, S., and Akagawa, K.S. (1995). Suppression of TNF-α mRNA expression in LPS-primed macrophages occurs at the level of nuclear factor-κB activation, but not at the level of protein kinase C or CD14 expression. J. Immun. 154, 4803-4812.
38. Tobias, P.S., Soldau, K., and Ulevitch, R.J. (1986). Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J. Exp. Med. 164, 777-793.
39. Virca, G.D., Kim, S.Y., Glaser, K.B., and Ulevitch, R.J. (1989). Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 264.7 cells. J. Biol. Chem. 264, 21951-21956.
40. West, M.A., Bennet, T., Seatter, S.C., Clair, L., and Bellingham, J. (1997). LPS pretreatment reprograms macrophage LPS-stimulated TNF and IL-1 release without protein tyrosine kinase activation. J. Leukoc. Biol. 61, 88-95.
41. Wright, S.D., Ramos, R.A., Robias, P.S., Ulevitch, R.J., and Mathison, J.C. (1990). CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249, 1431-1433.
42. Yang, R.-B., Mark, M.R., Gray, A., Huang, A., Xie, M.H., Zhang, M., Goddard, A., Wood, W.I., Gurney, A.L., and Godowski, P.J. (1998). Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signaling. Nature 395, 284-288.
43. Zhang, X., and Marrison, D.C. (1993). Lipopolysaccharide-induced selective priming effects on tumor necrosis factor alpha and nitric oxide production in mouse peritoneal macrophages. J. Exp. Med. 177, 511-516.
44. Ziegler-Heitbrock, H.W.L. (1995). Molecular mechanism in tolerance to lipopolysaccharide. J. Inflammation 45, 13-26.
45. Ziegler-Heitbrock, H.W.L., and Ulevitch, R.J. (1993). CD14: cell surface receptor and differentiation marker. Immunol. Today 14, 121-125.
46. Ziegler-Heitbrock, H.W.L., Passlick, B., and Flieger, D. (1988). The monoclonal antimonocyte antibody My4 stains B lymphocytes and two distinct monocyte subsets in human peripheral blood. Hybridoma 7, 521-527.
47. Ziegler-Heitbrock, H.W.L., Sternsdorf, T., Liese, J., Belohradsky, B., Weber, C., Wedel, A., Schreck, R., Bäuerle, P., and Ströbel, M. (1993). Pyrrolidine dithiocarbamate inhibits NF-κB mobilization and TNF production in human monocytes. J. Immunol. 151, 6986-6993.
48. Ziegler-Heitbrock, H.W.L., Pechumer, H., Petersmann, I., Durieux, J.J., Vita, N., Labeta, M.O., and Ströbel, M. (1994a). CD14 is expressed and functional in human B cells. Eur. J. Immunol. 24, 1937-1940.
49. Ziegler-Heitbrock, H.W.L., Wedel, A., Schraut, W., Ströbel, M., Wendelgass, P., Sternsdorf, T., Bäuerle, P., Haas, J.G., and Riethmüller, G. (1994b). Tolerance to lipopolysaccharide involves mobilization of nuclear factor κB with predominance of p50 homodimers. J. Biol. Chem. 269, 17001-17004.
50. Ziegler-Heitbrock, H.W.L., Frankenberger, M., and Wedel, A. (1995). Tolerance to lipopolysaccharide in human blood monocytes. Immunobiol. 193, 217-223.
51. Ziegler-Heitbrock, H.W.L., Petersmann, I., and Frankenberger, M. (1997). p50 (NF-κB1) is upregulated in LPS tolerant P388D1 murine macrophages. Immunobiol. 198, 73-80.
52. Zuckerman, S.H., Evans, G.F., Snyder, Y.M., and Roeder, W.D. (1989). Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression. J. Immunol. 143, 1223-1227.