Building new function into glycine receptors: A structural model for the activation of the glycine-gated chloride channel

Clinical and Experimental Pharmacology and Physiology

Volumn 26, Issue 11, 1999, Pages 932-934

  Lynch, Joseph W ^a   Han, Nian Lin R ^a   Schofield, Peter R ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

alanine; Hyperekplexia; Ligand gated ion channel; Structure function; Taurine

Indexed keywords

BETA ALANINE; CHLORIDE CHANNEL; CYSTEINE; GLYCINE; GLYCINE RECEPTOR; NICOTINIC RECEPTOR; PROTEIN; TAURINE;

CONFERENCE PAPER; CONTROLLED STUDY; GENETIC ANALYSIS; MODEL; NEUROTRANSMISSION; SIGNAL TRANSDUCTION; STARTLE EPILEPSY; STRUCTURE ACTIVITY RELATION;

BETA-ALANINE; CHLORIDE CHANNELS; CYSTEINE; GLYCINE; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTATION; RECEPTORS, GLYCINE; STARTLE REACTION; STRUCTURE-ACTIVITY RELATIONSHIP; TAURINE;

EID: 0032721066     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.1999.03150.x     Document Type: Conference Paper

References (17)

1. 1. Rajendra S, Lynch JW, Schofield PR. The glycine receptor. Pharmacol. Ther. 1997; 73: 121-46.
2. 2. Shiang R, Ryan SG, Zhu YZ, Hahn AF, O'Connell P, Wasmuth JJ. Mutations in the αl subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia. Nature Genet. 1993; 5: 351-8.
3. 3. Langosch D, Laube B, Rundström N, Schmieden V, Bormann J, Betz H, Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekpfexia, EMBO J. 1994; 13: 4223-8.
4. 4. Rajendra S, Lynch JW, Pierce KD, French CR, Barry PH, Schofield PR. Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor. J. Biol. Chem. 1994; 269: 18 739-42.
5. 5. Rajendra S, Lynch JW, Pierce KD, French CR, Barry PH, Schofield PR. Mutation of an arginine residue in the human glycine receptor transforms β-alanine and taurine from agonists into competitive antagonists. Neuron 1995; 14: 169-75.
6. 6. Laube B, Langosch D, Betz H, Schmieden V. Hyperekplexia mutations of the glycine receptor unmask the inhibitory subsite for β-amino acids. Neuroreport 1995; 6: 897-900.
7. 7. Lynch JW, Rajendra S, Barry PH, Schofield PR. Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator. J. Biol. Chem. 1995; 270: 13 799-806.
8. 8. Elmslie FV, Hutchings SM, Spencer V et al. Analysis of GLRAI in hereditary and sporadic hyperekplexia: A novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis. J. Med. Genet. 1996; 33: 435-6.
9. 9. Shiang R, Ryan SG, Zhu YZ et al. Mutational analysis of familial and sporadic hyperekplexia. Ann. Neurol. 1995; 38: 85-91.
10. 10. Rees MI, Andrew M, Jawad S, Owen MJ. Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the αl subunit of the inhibitory glycine receptor. Hum. Mol. Genet. 1994; 3: 2175--9.
11. 11. Lynch JW, Rajendra S, Pierce KD, Handford CA, Barry PH, Schofield PR. Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel, EMBO J. 1997; 16: 110-20.
12. 12. Akabas MH, Stauffer DA, Archdeacon P, Karlin A. Identification of acetyleholine receptor channel-lining residues in the entire M2 segment of the α2 subunit. Neuron 1994; 13: 919-27.
13. 13. Unwin N. Acetyleholine receptor channel imaged in the open state. Nature 1995; 373: 37-43.
14. 14. Laube B, Kuhse J, Rundstrom N, Kirsch J, Schmieden V, Betz. H. Modulation by zine of native rat und recombinant human inhibitory glycine receptors. J. Physiol. 1995; 483: 613-19.
15. 15. Lynch JW, Jacques P, Pierce KD, Sehofield PR. Zine potentiation of the glycine receptor chloride channel is mediated by allosteric pathways. J. Neurochem. 1998; 71: 2159-68.
16. 16. Akabas MH, Stauffer DA, Xu M, Karlin A, Acetyleholine receptor channel structure probed in cysteine-substitution mutants. Science 1992; 258: 307-10.
17. 17. Stauffer DA, Karlin A. The electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding site cysteines with charged methanethiosulfonates, Biochemistry 1994; 33: 6840-9.