Intrarenal infusion of bradykinin elicits a pressor response in conscious rats via a B2-receptor mechanism

Canadian Journal of Physiology and Pharmacology

Volumn 77, Issue 8, 1999, Pages 563-570

  Hoagland, Kimberly M ^a   Maddox, David A ^a,b   Martin, Douglas S ^a  

^a UNIVERSITY OF SOUTH DAKOTA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Autonomic nervous system; B2 receptors; Blood pressure; Bradykinin; Renal hemodynamics

Indexed keywords

BRADYKININ; BRADYKININ B2 RECEPTOR; ICATIBANT;

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR REFLEX; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; HEART RATE; INTRAARTERIAL DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSOR RESPONSE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SENSORY NERVE CONDUCTION; TACHYCARDIA;

EID: 0032720860     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y99-054     Document Type: Article

References (30)

1. 2 receptors. Hypertension, 29(part 2): 483-487.
2. Braun, C. Ade, M., Unger, T., van der Woude, F., and Rohmeiss, P. 1997. Effects of bradykinin and icatibant on renal hemodynamics in conscious spontaneously hypertensive and normotensive rats. J. Cardiovasc. Pharmacol. 30: 446-454.
3. Burch, R.M., Farmer, S.G., and Steranka, L.R. 1990. Bradykinin receptor antagonists. Med. Res. Rev. 10: 237-269.
4. Carretero, O.A., and Scicli, A.G. 1995. The kallikrein kinin system as a regulator of cardiovascular and renal function. In Hypertension: pathophysiology, diagnosis, and management. Vol. 1. Edited by J. Laragh and B. Brenner. Raven Press, New York. pp. 983-999.
5. DiBona, G., and Kopp. U. 1997. Neural control of renal function. Physiol. Rev. 77: 75-180.
6. Faber, J.E., and Gettes, D.R. 1987. Renal pressor reflex: involvement of sympathetic vasoconstrictor mechanisms. Am. J. Physiol. 252: H1147-H1158.
7. Fenoy, F.J., and Roman, R.J. 1992. Effects of kinin receptor anatagonists on renal hemodynamic and natriuretic responses to volume expansion. Am. J. Physiol. 263: R1136-R1140.
8. 2-adrenoceptors in the regional haemodynamic responses to bradykinin in conscious rats. Br. J. Pharmacol. 105: 839-848.
9. Granger, J.P., and Hall, J.E. 1985. Acute and chronic actions of bradykinin on renal functions and arterial pressure. Am. J. Physiol. 248: F87-F92.
10. Guyton, A., Hall, J., Coleman, T., Manning, R., Jr., and Norman, R., Jr. 1995. The dominant role of the kidneys in long-term arterial pressure regulation in normal and hypertensive states. In Hypertension: pathophysiology, diagnosis, and management. Edited by J. Laragh and B. Brenner. Raven Press. New York, pp. 1311-1326.
11. Haywood, J.R., Shaffer, R.A., Fastenow, C., Fink, G.D., and Brody, M.J. 1981. Regional blood flow measurement with pulsed Doppler flowmeter in conscious rat. Am. J. Physiol. 241: H273-H278.
12. Hoagland, K., Maddox, D., and Martin, D. 1997. Intrarenal infusion of bradykinin elicits a pressor response in conscious rats. FASEB J. 11: A266 (Abstr. 1545).
13. Jaassen, B.J., Van Essen, H., Boudier, H.A.S., and Smits, J.F. 1989. Hemodynamic effects of activation of renal and mesenteric sensory nerves in rats. Am. J. Physiol. 257: R29-R36.
14. Kimura, E., Hashimoto, K., Furukawa, S., and Hayakawa, J. 1973. Changes in bradykinin level in coronary sinus blood after the experimental occlusion of a coronary artery. Am. Heart J. 85: 635-647.
15. Kopp, U.C., Farley, D.M., and Smith, L.A. 1997. Bradykinin-mediated activation of renal sensory neurons due to prostaglandin-dependent release of substance P. Am. J. Physiol. 272: R2009-R2016.
16. Lew, W.Y.W., and Longhurst, J.C. 1986. Substance P, 5-hydroxytryptamine, and bradykinin stimulate abdominal visceral afferents. Am. J. Physiol. 250: R465-R473.
17. Longhurst, J.C., and Dittman, L.E. 1987. Hypoxia, bradykinin, and prostaglandins stimulate ischemically sensitive visceral afferents. Am. J. Physiol. 253: H556-H567.
18. Majima, M., and Katori, M. 1995. Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system. Trends Pharmacol. Sci. 16: 239-246.
19. Mattson, D.L., and Cowley, A.W. 1993. Kinin actions on renal papillary blood flow and sodium exeretion. Hypertension, 21: 961-965.
20. McDermott, D.A., Meller, S.T., Gebhart, G.F., and Gutterman, D.D. 1995. Use of an indwelling catheter for examining cardio-vascular responses to pericardial administration of bradykinin in rat. Cardiovasc. Res. 30: 39-46.
21. Pan, H.-L., Stebbins, C.L., and Longhurst, J.C. 1993. Biadykinin contributes to the exercise pressor reflex: mechanism of action. J. Appl. Physiol. 75: 2061-2068.
22. Pan, H.-L., Stahl, G.L., Rendig, S.V., Carretero, O.A., and Longhurst, J.C. 1994. Endogenous BK stimulates ischemically sensitive abdominal visceral C fiber afferents through kinin B2 receptors. Am. J. Physiol. 267: H2398-H2406.
23. Patel, K.P., and Knuepfer, M.M. 1986. Effect of afferent renal nerve stimulation on blood pressure, heart rate and noradrenergic activity in conscious rats. J. Auton. Nerv. Syst. 17: 121-130.
24. Roman, R.J., Kaldunski, M.L., Scicli, A.G., and Carretero, O.A. 1988. Influence of kinins and angiotensin II on the regulation of papillary blood flow. Am. J. Physiol. 88: F690-F698.
25. Scicli, A.G., and Carreter, O.A. 1986. Renal kallikrein-kinin system. Kidney Int. 29: 120-130.
26. Siragy, H. 1993. Evidence that intrarenal bradykinin plays a role in regulation of renal function. Am. J. Physiol. 268: E648-E654.
27. Smits, J.F.M., and Brody, M.J. 1984. Activation of afferent renal nerves by intrarenal bradykinin in conscious rats. Am. J. Physiol. 247: R1003-R1008.
28. Weaver, L.C., Stein, R.D., Tobey, J.C., and Meckler, R.L. 1986. Patterns of sympathetic reflexes generated by chemical stimulation of visceral receptors. In Neural mechanisms and cardiovascular disease. Edited by B. Lown, A. Malliani, and M. Prosdocimi. Liviana, Padua, pp. 97-107.
29. Wyss, J.M., Aboukarsh, N., and Oparil, S. 1986. Sensory denervation of the kidney attenuates renovascular hypertension in the rat. Am. J. Physiol. 250: H82-H86.
30. Yu, H., Carretero, O., Juncos, L., and Garvin, J. 1998. Biphasic effect of bradykinin on rabbit afferent arterioles. Hypertension, 32: 287-292.