CSF 5-HIAA and aggression in female macaque monkeys: Species and interindividual differences

Psychopharmacology

Volumn 146, Issue 4, 1999, Pages 440-446

  Westergaard, G C ^a,b   Suomi, S J ^b   Higley, J D ^c   Mehlman, P T ^a  

^a DIVISION OF RESEARCH   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Aggression; Female; Impulsivity; Primates; Serotonin; Social dominance

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; SEROTONIN;

5 HYDROXYINDOLEACETIC ACID BRAIN LEVEL; AGGRESSION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CEREBROSPINAL FLUID; FEMALE; IMPULSIVENESS; MACACA; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SEROTONIN RELEASE; SEROTONIN UPTAKE; SEROTONINERGIC SYSTEM; SOCIAL DOMINANCE; SPECIES DIFFERENCE;

AGGRESSION; ANIMALS; BIOLOGICAL MARKERS; FEMALE; HYDROXYINDOLEACETIC ACID; INDIVIDUALITY; MACACA; SOCIAL DOMINANCE; SPECIES SPECIFICITY;

EID: 0032718978     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005489     Document Type: Article

References (52)

1. Agren H, Mefford IN, Rudorfer MV, Linnoila M, Potter WZ (1986) Interacting neurotransmitter systems: a non-experimental approach to the 5-HIAA-HVA correlation in human CSF. Psychiatry Res 20:175-193
2. Altmann J (1974) Observational study of behavior: sampling methods. Behaviour 49:227-267
3. Altmann SA (1962) A field study of the sociobiology of rhesus monkeys, Macaca mulatta. Ann NY Acad Sci 102:338-435
4. Ballenger JC, Goodwin FK, Major LF, Brown GL (1979) Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry 36:224-227
5. Banki CM, Molnar G, Fekete I (1981) Correlation of individual symptoms and other clinical variables with cerebrospinal fluid amine metabolites and tryptophan in depression. Arch Psychiatr Nervenkrank 229:345-353
6. Bernstein IS, Gordon TP (1974) The function of aggression in primate societies. Am Sci 62:04-311
7. Borg S, Kvande H, Liljeberg P, Mossberg D, Valverius P (1985) 5-Hydroxyindoleacetic acid in cerebrospinal fluid in alcoholic patients under different clinical conditions. Alcohol 2:415-418
8. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF (1979) Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1:131-139
9. Brown GL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WEJ, Goodwin FK (1982) Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 139:741-746
10. Chapais B (1986) Why do male and female rhesus monkeys affiliate during the birth season? In: Rawlins RG, Kessler M (eds) The Cayo Santiago macaques. SUNY Press, Chicago, pp 173-200
11. Chapais B (1988) Rank maintenance in female Japanese macaques: experimental evidence for social dependency. Behaviour 102:41-59
12. Higley JD, Linnoila M (1997) Low CNS serotonergic activity is trait-like and correlates with impulsive behavior: a nonhuman primate model investigating genetic and environmental influences on neurotransmission. Ann NY Acad Sci 836:39-56
13. Higley JD, Linnoila M (1999) Low CNS serotonergic activity is trait-like and correlates with impulsive behavior: a nonhuman primate model investigating genetic and environmental influences on neurotransmission. Ann NY Acad Sci (in press)
14. Higley JD, Suomi SJ (1996) Effect of reactivity and social competence on individual responses to severe stress in children: investigations using nonhuman primates. In: Pfeffer CR (ed) Intense stress and mental disturbance in children. American Psychiatric Press, Washington, D.C., pp 1-69
15. Higley JD, Mehlman P, Taub D, Higley SB, Vickers JH, Suomi SJ, Linnoila M (1992a) Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Arch Gen Psychiatry 49:436-441
16. Higley JD, Suomi SJ, Linnoila M (1992b) A longitudinal assessment of CSF monoamine metabolite and plasma cortisol concentrations in young rhesus monkeys. Biol Psychiatry 32:127-145
17. Higley JD, Linnoila M, Suomi SJ (1994) Ethological contributions: experiential and genetic contributions to the expression and inhibition of aggression in primates. In: Hersen M, Ammerman RT, Sisson L (eds) Handbook of aggressive and destructive behavior in psychiatric patients. Plenum Press, New York, pp 17-32
18. Higley JD, King ST, Hasert MF, Champoux M, Suomi SJ, Linnoila M (1996a) Stability of interindividual differences in serotonin function and its relationship to aggressive wounding and competent social behavior in rhesus macaque females. Neuropsychopharmacology 14:67-76
19. Higley JD, Mehlman PT, Higley SB, Fernald B, Vickers J, Lindell SG, Taub DM, Suomi SJ, Linnoila M (1996b) Excessive mortality in young free-ranging male nonhuman primates with low cerebrospinal fluid 5-hydroxyindoleacetic acid. Arch Gen Psychiatry 53:537-543
20. Higley JD, Mehlman PT, Poland RE, Taub DT, Vickers J, Suomi SJ, Linnoila M (1996c) CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors. Biol Psychiatry 40:1067-1082
21. Higley JD, Suomi SJ, Linnoila M (1996d) A nonhuman primate model of type II alcoholism? Part 2. Diminished social competence and excessive aggression correlates with low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. Alcoholism Clin Exp Res 20:643-650
22. Higley JD, Suomi SJ, Linnoila M (1996e) A nonhuman primate model of type II excessive alcohol consumption? Part 1. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations and diminished social competence correlate with excessive alcohol consumption. Alcohol Clin Exp Res 20:629-642
23. Kruesi MJ, Rapoport JL, Hamburger S, Hibbs E, Potter WZ, Lenane M, Brown GL (1990a) Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Arch Gen Psychiatry 47:419-426
24. Kruesi MJ, Swedo S, Leonard H, Rubinow DR, Rapoport JL (1990b) CSF somatostatin in childhood psychiatric disorders: a preliminary investigation. Psychiatry Res 33:277-284
25. Linnoila VM, Virkkunen M (1992) Aggression, suicidality, and serotonin. J Clin Psychiatry 53:46-51
26. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK (1983) Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci 33:2609-2614
27. Madsen D (1994) Serotonin and social rank among human males. In: Masters RD, McGuire MT (eds) The neurotransmitter revolution. Southern Illinois University Press, Carbondale, pp 146-158
28. McGuire MT, Brammer GL, Raleigh MJ (1986) Resting cortisol levels and the emergence of dominant status among male vervet monkeys. Horm Behav 20:106-117
29. Mehlman PT, Higley JD, Faucher I, Lilly AA, Taub DM, Suomi S, Linnoila M (1994) Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. Am J Psychiatry 151:1485-1491
30. Mehlman P, Higley JD, Faucher I, Lilly AA, Taub DM, Vickers JH, Suomi S, Linnoila M (1995) Correlation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates. Am J Psychiatry 152:907-913
31. Mehlman PT, Higley JD, Fernald BJ, Sallee FR, Suomi SJ, Linnoila M (1997) CSF 5-HIAA, testosterone, and sociosexual behaviors in free-ranging male rhesus macaques in the mating season. Psychiatry Res 72:89-102
32. Moss HB (1987) Serotonergic activity and disinhibitory psychopathy in alcoholism. Med Hypoth 23:353-361
33. Popova NK, Kulikov AV, Nikulina EM, Kozlachkova EY, Maslova GB (1991a) Serotonin metabolism and serotonergic receptors in Norway rats selected for low aggressiveness towards man. Aggress Behav 17:207-213
34. Popova NK, Voitenko NN, Kulikov AV, Avgustinovich DF (1991b) Evidence for the involvement of central serotonin in mechanism of domestication of silver foxes. Pharmacol Biochem Behav 40:751-756
35. Raleigh MJ (1987) Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems. Psychopharmacology 93:44-50
36. Raleigh MJ, McGuire MT (1986) Animal analogues of ostracism: biological mechanisms and social consequences. Ethol Sociobiol 7:53-66
37. Raleigh MJ, McGuire MT (1991) Bidirectional relationships between tryptophan and social behavior in vervet monkeys. Adv Exp Med Biol 294:289-298
38. Raleigh MJ, McGuire MT (1994) Serotonin, aggression, and violence in vervet monkeys. In: Masters RD, McGuire MT (eds) The neurotransmitter revolution. Southern Illinois University Press, Carbondale, pp 129-145
39. Raleigh MJ, Brammer GL, Yuwiler A, Flannery JW, McGuire MT (1980) Serotonergic influences on the social behavior of vervet monkeys (Cercopithecus aethiops sabaeus). Exp Neurol 68:322-334
40. Raleigh MJ, Brammer GL, McGuire MT (1983) Male dominance, serotonergic systems, and the behavioral and physiological effects of drugs in vervet monkeys (Cercopithecus aethiops sabaeus). In: Miczek KA (ed) Ethopharmacology: primate models of neuropsychiatric disorders. Liss, New York, pp 185-197
41. Raleigh MJ, Brammer GL, Ritvo ER, Geller E, McGuire MT, Yuwiler A (1986) Effects of chronic fenfluramine on blood serotonin, cerebrospinal fluid metabolites, and behavior in monkeys. Psychopharmacology 90:503-508
42. Raleigh MJ, McGuire MT, Brammer GL, Pollack DB, Yuwiler A (1991) Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys. Brain Res 559:181-190
43. Raleigh MJ, Brammer GL, McGuire MT, Pollack DB, Yuwiler A (1992) Individual differences in basal cisternal cerebrospinal fluid 5-HIAA and HVA in monkeys. The effects of gender, age, physical characteristics, and matrilineal influences. Neuropsychopharmacology 7:295-304
44. Roy A, De JJ, Linnoila M (1989) Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. A 5-year follow-up study. Arch Gan Psychiatry 46:609-612
45. Scheinin M, Chang WH, Jimerson DC, Linnoila M (1983) Measurement of 3-methoxy-4-hydroxyphenylglycol in human plasma with high-performance liquid chromatography using electrochemical detection. Anal Biochem 132:165-170
46. Shively CA, Fontenot MB, Kaplan JR (1995) Social status, behavior, and central serotonergic responsivity in female cynomolgus monkeys. Am J Primatol 37:333-340
47. Sirianni JS (1985) Growth and development of the pigtailed macaque. CRC Press, Boca Raton
48. van Hooff JARAM (1967) The facial displays of the catarrhine monkeys and apes. In: Morris D (ed) Primate ethology. Aldine Publishing Company, Chicago, pp 7-68
49. Virkkunen M, De Jong J, Bartko J, Linnoila M (1989) Psychobiological concomitants of history of suicide attempts among violent offenders and impulsive fire setters. Arch Gen Psychiatry 46:604-606
50. Virkkunen M, Kallio E, Rawlings R, Tokola R, Poland RE, Guidotti A, Nemeroff C, Bissette G, Kalogeras K, Karonen SL, Linnoila M (1994a) Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 51:28-33
51. Virkkunen M, Rawlings R, Tokola R, Poland RE, Guidotti A, Nemeroff C, Bissette G, Kalogeras K, Karonen SL, Linnoila M (1994b) CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 51:20-27
52. Yodyingyuad U, de la Riva C, Abbott DH, Herbert J, Keverne EB (1985) Relationship between dominance hierarchy, cerebrospinal fluid levels of amine transmitter metabolites (5-hydroxyindole acetic acid and homovanillic acid) and plasma cortisol in monkeys. Neuroscience 16:851-858