G009. Hepatoprotectant immunostimulant

Drugs of the Future

Volumn 24, Issue 10, 1999, Pages 1068-1071

  Baek, Seong Jin ^a   Jung, Won Tae ^a   Kim, Dong Yeon ^a   Cho II, Kil Do ^a  

^a II Yang Central Research Institute   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BETA 1,3 GLUCAN; CARBON TETRACHLORIDE; COLLAGEN; G 009; GANODERMA LUCIDUM EXTRACT; HYDROXYPROLINE; LIPID; LIVER PROTECTIVE AGENT; NITRIC OXIDE; PARACETAMOL; POLYSACCHARIDE; UNCLASSIFIED DRUG;

ANTIGENICITY; ANTINEOPLASTIC ACTIVITY; BASIDIOMYCETES; CLINICAL TRIAL; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG STABILITY; HUMAN; IMMUNE SYSTEM; IMMUNOSTIMULATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER; MUTAGENICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; REVIEW;

EID: 0032718658     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1999.024.10.548889     Document Type: Review

References (16)

1. Jong, S.C., Birmingham, J.M. Medicinal benefits of the mushroom Ganoderma. Adv Appl Microbiol 1992, 37: 101-34.
2. Miyazaki, T., Nishijima, M. Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumor polysaccharide of Ganoderma lucidum. Chem Pharm Bull 1981, 29: 3611-6.
3. Park, E.J., Kim, K.Y., Kim, S.W., Lee, S.Y., Sohn, D.H. The antifibrotic effects of polysaccharides extract from Ganoderma lucidum on experimental hepatic cirrhosis. Yakhak Hoeji 1994, 38: 338-44.
4. Ukai, S., Kiho, T., Hara, C., Kuruma, I., Tanaka, Y. Polysaccharides in fungi. XIV. Anti-inflammatory effect of the polysaccharides from the fruit bodies of several fungi. J Pharmacobio-Dyn 1983, 6: 983-90.
5. Lee, J.W., Jeong, H., Han, M.D., Beak, S.J., Kim, Y.S., Kang, S.M. Effect of G009 on CCI4-induced hepatic injury and lipid peroxidation in rats. Korean J Pharmacogn 1996, 27: 159-66.
6. Chung, H.T. Effect of G009 (extract of Ganoderma lucidum mycelium) on the nitric oxide from macrophage-derived cell line (Raw 264.7). Proc Int Symp Ganoderma lucidum (June 17, Seoul) 1993, 39-54.
7. Moncada, S.R., Palmer, M.J., Higgs, E.A. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991, 43: 109-42.
8. Sone, Y., Okuda, R., Wada, N., Kishida, E., Misaki, A. Structures and antitumor activities of the polysaccharides isolated from fruiting body and the growing culture of mycelium of Ganoderma lucidum. Agric Biol Chem 1985, 49: 2641-53.
9. Stavinoha, W.B., Hardman, W.E., Cameron, I.L. Short term dietary supplementation with Ganoderma lucidum slows development and growth of microadenomatous lesions in the colon of rats treated with the carcinogen 1,2-dimethylhydrazine. Proc Int Symp Ganoderma lucidum (June 17, Seoul) 1993, 12-22.
10. 14C. Eur J Drug Metab Pharmacokinet 1989, 14: 187-94.
11. 14C]-substrates in rats. II. Differences with the nature and administration route of the injection fluid. Eur J Drug Metab Pharmacokinet 1991, 16: 35-41.
12. Earl, F.L., Melveger, B.E., Wilson, R.L The hemogram and bone marrow profile of normal neonate and weanling dogs. Lab Animal Sci 1973, 23: 690-5.
13. Hayashi, M., Yoshimura, I., Sofuni, T., Ishidate, M. Jr. A procedure for data analysis of the rodent micronucleus test involving a historical control. Environ Mol Mutagen 1989, 13: 347-56.
14. Maron, D.M., Ames, B.N. Revised methods for the Salmonella mutagenicity test. Mutat Res 1983, 113: 173-215.
15. Hudson, L., Hay, F.C. In: Practical Immunology. Blackwell Scientific Publications: Oxford 1989, 207-63.
16. Levine, B.B., Vaz, N.M. Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagin production in the mouse. A potential mouse model for immune aspects of human atopic allergy, Int Arch Allergy Appl Immunol 1970, 39: 156-71.