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Volumn 9, Issue 5, 1999, Pages 601-605

Genetic polymorphism of CYP2D6 in the Japanese population

Author keywords

Cancer risk; CYP2D6*18; CYP2D6*3; CYP2D6*4; CYP2D6*5; Parkinson's disease; Population study

Indexed keywords

ARTICLE; CANCER; COLORECTAL CANCER; CONTROLLED STUDY; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; JAPAN; LUNG CANCER; MAJOR CLINICAL STUDY; PARKINSON DISEASE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0032717824     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (42)

References (40)
  • 2
    • 0028358565 scopus 로고
    • The cytochrome P450 CYP2D6 allelic variant CYP2D6 J and related polymorphism in a European population
    • Armstrong M, Fairbrother K, Idle JR, Daly AK. The cytochrome P450 CYP2D6 allelic variant CYP2D6 J and related polymorphism in a European population. Pharmacogenetics 1994; 4:73-81.
    • (1994) Pharmacogenetics , vol.4 , pp. 73-81
    • Armstrong, M.1    Fairbrother, K.2    Idle, J.R.3    Daly, A.K.4
  • 3
    • 0025950370 scopus 로고
    • Debrisoquine/sparteine hydroxylation genotype and phenotype: Analysis of common mutations and alleles of CYP2D6 in a European population
    • Broly F, Gaedigk A, Heim M, Eichelbaum M, Morike K, Meyer UA. Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population. DNA Cell Biol 1991; 8:545-558.
    • (1991) DNA Cell Biol , vol.8 , pp. 545-558
    • Broly, F.1    Gaedigk, A.2    Heim, M.3    Eichelbaum, M.4    Morike, K.5    Meyer, U.A.6
  • 4
    • 0028806579 scopus 로고
    • A nonsense mutation in the cytochrome P450 CYP2D6 gene identified in a Caucasian with an enzyme deficiency
    • Broly F, Mare D, LoGuidice JM, Sabbagh N, Legrand M, Boone P, Meyer UA. A nonsense mutation in the cytochrome P450 CYP2D6 gene identified in a Caucasian with an enzyme deficiency. Human Genet 1995; 96:601-603.
    • (1995) Human Genet , vol.96 , pp. 601-603
    • Broly, F.1    Mare, D.2    Loguidice, J.M.3    Sabbagh, N.4    Legrand, M.5    Boone, P.6    Meyer, U.A.7
  • 6
    • 0029053644 scopus 로고
    • Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects
    • Dahl ML, Yue QY, Roh HK, Johansson I, Säwe J, Sjöqvist F, Bertilsson L. Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects. Pharmacogenetics 1995; 5:159-164.
    • (1995) Pharmacogenetics , vol.5 , pp. 159-164
    • Dahl, M.L.1    Yue, Q.Y.2    Roh, H.K.3    Johansson, I.4    Säwe, J.5    Sjöqvist, F.6    Bertilsson, L.7
  • 8
    • 0025305464 scopus 로고
    • The genetic polymorphism of debrisoquine/sparteine metabolism - Clinical aspects
    • Eichelbaum M, Gross AS. The genetic polymorphism of debrisoquine/sparteine metabolism - clinical aspects. Pharmacol Ther 1990; 46:377-394.
    • (1990) Pharmacol Ther , vol.46 , pp. 377-394
    • Eichelbaum, M.1    Gross, A.S.2
  • 9
    • 0018900001 scopus 로고
    • A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population
    • Evans DAP, Mahgoub A, Sloan TP, Idle JR, Smith RL. A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. J Med Genet 1980; 17:102-105.
    • (1980) J Med Genet , vol.17 , pp. 102-105
    • Evans, D.A.P.1    Mahgoub, A.2    Sloan, T.P.3    Idle, J.R.4    Smith, R.L.5
  • 10
    • 0027276869 scopus 로고
    • Genetic basis for low prevalence of deficient CYP2D6 oxidative drug metabolism in black Americans
    • Evans WE, Relling MV, Rahman A, McLeod HL, Scott EP, Lin JS. Genetic basis for low prevalence of deficient CYP2D6 oxidative drug metabolism in black Americans. J Clin Invest 1993; 91:2150-2154.
    • (1993) J Clin Invest , vol.91 , pp. 2150-2154
    • Evans, W.E.1    Relling, M.V.2    Rahman, A.3    McLeod, H.L.4    Scott, E.P.5    Lin, J.S.6
  • 11
    • 0028109283 scopus 로고
    • A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine
    • Evert B, Griese EU, Eichelbaum M. A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine. Naunyn-Schmiedeberg's Arch Pharmacol 1994; 350:434-439.
    • (1994) Naunyn-Schmiedeberg's Arch Pharmacol , vol.350 , pp. 434-439
    • Evert, B.1    Griese, E.U.2    Eichelbaum, M.3
  • 12
    • 0025805934 scopus 로고
    • Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism
    • Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA. Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am J Human Genet 1991; 48:943-950.
    • (1991) Am J Human Genet , vol.48 , pp. 943-950
    • Gaedigk, A.1    Blum, M.2    Gaedigk, R.3    Eichelbaum, M.4    Meyer, U.A.5
  • 13
    • 0023854270 scopus 로고
    • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
    • Gonzalez FJ, Skoda RC, Kimura S, Umeno M, Zanger UM, Nebert DW, et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 1988; 331:442-446.
    • (1988) Nature , vol.331 , pp. 442-446
    • Gonzalez, F.J.1    Skoda, R.C.2    Kimura, S.3    Umeno, M.4    Zanger, U.M.5    Nebert, D.W.6
  • 15
    • 0025080352 scopus 로고
    • Genotyping of poor metabolizers of debrisoquine by allele-specific PCR amplification
    • Heim M, Meyer UA. Genotyping of poor metabolizers of debrisoquine by allele-specific PCR amplification. Lancet 1990; 336:529-532.
    • (1990) Lancet , vol.336 , pp. 529-532
    • Heim, M.1    Meyer, U.A.2
  • 16
    • 0024442372 scopus 로고
    • Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese vs. mainland Chinese
    • Horai Y, Nakano M, Ishizaki T, Ishikawa K, Zhou HH, Zhou BJ, et al. Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese vs. mainland Chinese. Clin Pharmacol Ther 1989; 46:198-207.
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 198-207
    • Horai, Y.1    Nakano, M.2    Ishizaki, T.3    Ishikawa, K.4    Zhou, H.H.5    Zhou, B.J.6
  • 18
    • 0025890423 scopus 로고
    • Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine
    • Johansson I, Yue QY, Dahl ML, Heim M, Säwe J, Bertilsson L, et al. Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine. Eur J Clin Pharmacol 1991; 40:553-556.
    • (1991) Eur J Clin Pharmacol , vol.40 , pp. 553-556
    • Johansson, I.1    Yue, Q.Y.2    Dahl, M.L.3    Heim, M.4    Säwe, J.5    Bertilsson, L.6
  • 19
    • 0025036544 scopus 로고
    • Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine
    • Kagimoto M, Heim M, Kagimoto K, Zeugin T, Meyer UA. Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. J Biol Chem 1990; 265:17209-17214.
    • (1990) J Biol Chem , vol.265 , pp. 17209-17214
    • Kagimoto, M.1    Heim, M.2    Kagimoto, K.3    Zeugin, T.4    Meyer, U.A.5
  • 20
    • 0024796958 scopus 로고
    • The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
    • Kimura S, Umeno M, Skoda RC, Meyer UA, Gonzalez FJ. The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am J Hum Genet 1989; 45:889-904.
    • (1989) Am J Hum Genet , vol.45 , pp. 889-904
    • Kimura, S.1    Umeno, M.2    Skoda, R.C.3    Meyer, U.A.4    Gonzalez, F.J.5
  • 21
    • 0027330416 scopus 로고
    • Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease
    • Kurth MC, Kurth JH. Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease. Am J Med Genet 1993; 48:166-168.
    • (1993) Am J Med Genet , vol.48 , pp. 166-168
    • Kurth, M.C.1    Kurth, J.H.2
  • 22
    • 0028826569 scopus 로고
    • A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype
    • Marez D, Sabbagh N, Legrand M, LoGuidice JM, Boone P, Broly F. A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype. Pharmacogeneties 1995; 5:305-311.
    • (1995) Pharmacogeneties , vol.5 , pp. 305-311
    • Marez, D.1    Sabbagh, N.2    Legrand, M.3    LoGuidice, J.M.4    Boone, P.5    Broly, F.6
  • 24
    • 0021146282 scopus 로고
    • Impaired oxidation of debrisoquine in patients with perhexline liver injury
    • Morgan MY, Reshef R, Shah RR, Oates NS, Smith RL, Sherlock S. Impaired oxidation of debrisoquine in patients with perhexline liver injury. Gut 1984; 25:1057-1064.
    • (1984) Gut , vol.25 , pp. 1057-1064
    • Morgan, M.Y.1    Reshef, R.2    Shah, R.R.3    Oates, N.S.4    Smith, R.L.5    Sherlock, S.6
  • 25
    • 0022178173 scopus 로고
    • Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations
    • Nakamura K, Goto F, Ray WA, McAllister CB, Jacqz E, Wilkinson GR, Branch RA. Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin Pharmacol Ther 1985; 38:402-408.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 402-408
    • Nakamura, K.1    Goto, F.2    Ray, W.A.3    McAllister, C.B.4    Jacqz, E.5    Wilkinson, G.R.6    Branch, R.A.7
  • 27
    • 0028963458 scopus 로고
    • Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: Regulation and toxicological significance
    • Rannug A, Alexandrie AK, Persson I, Ingelman-Sundberg M. Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance. J Occup Environ Med 1995; 37:25-36.
    • (1995) J Occup Environ Med , vol.37 , pp. 25-36
    • Rannug, A.1    Alexandrie, A.K.2    Persson, I.3    Ingelman-Sundberg, M.4
  • 28
    • 0026004805 scopus 로고
    • Lower prevalence of the debrisoquine oxidative poor metaboliser phenotype in American blacks vs. white subjects
    • Relling MV, Cherrie J, Schell MJ, Petros WP, Meyer WH, Evans WE. Lower prevalence of the debrisoquine oxidative poor metaboliser phenotype in American blacks vs. white subjects. Clin Pharmacol Ther 1991; 50:308-313.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 308-313
    • Relling, M.V.1    Cherrie, J.2    Schell, M.J.3    Petros, W.P.4    Meyer, W.H.5    Evans, W.E.6
  • 30
    • 0028305240 scopus 로고
    • Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor melabolizer phenotype
    • Saxena R, Shaw GL, Relling MV, Frame JN, Moir DT, Fvans WF, et al. Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor melabolizer phenotype. Hum Mol Genet 1994; 3:923-926.
    • (1994) Hum Mol Genet , vol.3 , pp. 923-926
    • Saxena, R.1    Shaw, G.L.2    Relling, M.V.3    Frame, J.N.4    Moir, D.T.5    Fvans, W.F.6
  • 31
    • 0345638787 scopus 로고
    • Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs
    • Skoda RC, Gonzalez FJ, Demierre A, Meyer UA. Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. Proc Natl Acad Sci USA 1988; 85:5240-5243.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 5240-5243
    • Skoda, R.C.1    Gonzalez, F.J.2    Demierre, A.3    Meyer, U.A.4
  • 32
    • 0001144226 scopus 로고
    • Introduction. Human genetic variations in oxidative drug metabolism
    • Smith RL. Introduction. Human genetic variations in oxidative drug metabolism. Xenobiotica 1986; 16:361-365.
    • (1986) Xenobiotica , vol.16 , pp. 361-365
    • Smith, R.L.1
  • 34
    • 0026091975 scopus 로고
    • Metoprolol oxidation polymorphism in a Korean population: Comparison with native Japanese and Chinese populations
    • Sohn DR, Shin SG, Park CW, Kusaka M, Chiba K, Ishizaki T. Metoprolol oxidation polymorphism in a Korean population: Comparison with native Japanese and Chinese populations, Br J Clin Pharmacol 1991; 32:504-507
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 504-507
    • Sohn, D.R.1    Shin, S.G.2    Park, C.W.3    Kusaka, M.4    Chiba, K.5    Ishizaki, T.6
  • 35
    • 0022179340 scopus 로고
    • A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin
    • Steiner E, Iselius L, Alván G. Lindsten J, Sjöqvist F. A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin. Clin Pharmacol Ther 1985; 38:394-401.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 394-401
    • Steiner, E.1    Iselius, L.2    Alván, G.3    Lindsten, J.4    Sjöqvist, F.5
  • 36
    • 0028289040 scopus 로고
    • Clinical implications of genetic polymorphism in drug metabolism
    • Tucker GT. Clinical implications of genetic polymorphism in drug metabolism. J Pharm Pharmacol 1994; 46:417-424.
    • (1994) J Pharm Pharmacol , vol.46 , pp. 417-424
    • Tucker, G.T.1
  • 37
    • 0027200680 scopus 로고
    • A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease
    • Tsuneoka Y, Matsuo Y, Iwahashi K, Takeuchi H, Ichikawa Y. A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease. J Biochem 1993; 114:263-266.
    • (1993) J Biochem , vol.114 , pp. 263-266
    • Tsuneoka, Y.1    Matsuo, Y.2    Iwahashi, K.3    Takeuchi, H.4    Ichikawa, Y.5
  • 38
    • 0027418152 scopus 로고
    • Molecular basis of genetic variation in debrisoquine hydroxylation in Chinese subjects: Polymorphism in RFLP and DNA sequence of CYP2D6
    • Wang SL, Haung J, Lai MD, Liu BH, Lai ML. Molecular basis of genetic variation in debrisoquine hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6. Clin Pharmacol Ther 1993; 53:410-418.
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 410-418
    • Wang, S.L.1    Haung, J.2    Lai, M.D.3    Liu, B.H.4    Lai, M.L.5
  • 39
    • 10344266435 scopus 로고    scopus 로고
    • A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype
    • Yokoi T, Kosaka Y, Chida M, Chiba K, Nakamura H, Ishizaki T, et al. A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype. Pharmacogenetics 1996; 6:395-401.
    • (1996) Pharmacogenetics , vol.6 , pp. 395-401
    • Yokoi, T.1    Kosaka, Y.2    Chida, M.3    Chiba, K.4    Nakamura, H.5    Ishizaki, T.6
  • 40
    • 0027527966 scopus 로고
    • Evidence for a new variant CYP2D6 allele CYP2D6 J in a Japanese population associated with lower in vivo rates of sparteine metabolism
    • Yokota H, Tamura S, Furuya H, Kimura S, Watanabe M, Kanazawa I, et al. Evidence for a new variant CYP2D6 allele CYP2D6 J in a Japanese population associated with lower in vivo rates of sparteine metabolism. Pharmacogenetics 1993; 3:256-263b
    • (1993) Pharmacogenetics , vol.3
    • Yokota, H.1    Tamura, S.2    Furuya, H.3    Kimura, S.4    Watanabe, M.5    Kanazawa, I.6


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