Is dedifferentiated chondrosarcoma a 'de-differentiated' chondrosarcoma?

Journal of Pathology

Volumn 189, Issue 4, 1999, Pages 445-447

  Aigner, T ^a   Unni, K K ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b MAYO CLINIC   (United States)

Author keywords

Bone tumours; Cartilage; Chondrocyte differentiation; Dedifferentiated chondrosarcoma

Indexed keywords

CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROSARCOMA; HUMAN; PRIORITY JOURNAL; REVIEW; TUMOR DIFFERENTIATION;

BONE NEOPLASMS; CHONDROSARCOMA; CLONE CELLS; HUMANS; NEOPLASTIC PROCESSES; PHENOTYPE;

EID: 0032716775     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199912)189:4<445::AID-PATH468>3.0.CO;2-M     Document Type: Review

References (29)

1. Dahlin DC, Beabout JW. Dedifferentiation of low-grade chondrosarcomas. Cancer 1971; 28: 461-466.
2. Johnson S, Têtu B, Ayala AG, Chawla SP. Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma) - I. A clinicopathologic study of 26 cases. Cancer 1986; 58: 278-286.
3. Capanna R, Bertoni F, Bettelli G, et al. Dedifferentiated chondrosarcoma. J Bone Jt Surg 1988; 70-A: 60-69.
4. Unni KK. Dahlin's Bone Tumors (5th edn). Lippincott-Raven: Philadelphia, 1996; 1-463.
5. Frassica FJ, Unni KK, Beabout JW, Sim FH. Dedifferentiated chondrosarcoma. A report of the clinicopathological features and treatment of seventy-eight cases. J Bone Jt Surg 1986; 68A: 1197-1205.
6. Dervan PA, Loughlin JO, Hurson BJ. Dedifferentiated chondrosarcoma with muscle and cytokeratin differentiation in the anaplastic component. Histopathology 1987; 12: 517-526.
7. Akenoza P, Neumann P, Manivel JC, Wick MR. Dedifferentiated chondrosarcoma: an ultrastructural study of two cases, with immunocytochemical correlations. Ultrastruct Pathol 1986; 10: 529-538.
8. Aigner T, Dertinger S, Neureiter D, Kirchner T. De-differentiated chondrosarcoma is not a 'de-differentiated' chondrosarcoma. Histopathology 1998; 33: 11-19.
9. Sanerkin NG, Woods CG. Fibrosarcomata and malignant fibrous histiocytoma arising in relation to enchondromata. J Bone Jt Surg 1979; 61B: 366-372.
10. Tétu B, Ordónez NG, Ayala AG, Mackay B. Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma) -II. An immunohistochemical and electron microscopic study. Cancer 1986; 58: 287-298.
11. Wick MR, Siegal GP, Mills SE, Thompson RC, Sawhney D, Fechner RE Dedifferentiated chondrosarcoma of bone. An immunohistochemical and lectin-histochemical study. Virchows Arch A 1987; 411: 23-32.
12. Fechner RE, Mills SE. Tumors of the Bones and Joints, vol 8. Armed Forces Institute of Pathology: Washington, DC, 1993.
13. Aigner T, Dertinger S, Vornehm SI, Dudhia J, von der Mark K, Kirchner T. Phenotypic diversity of neoplastic chondrocytes and extracellular matrix gene expression in cartilaginous neoplasms. Am J Pathol 1997; 150: 2133-2141.
14. Kahn LB. Chondcosarcoma with dedifferentiated foci. Cancer 1976; 37: 1365-1375.
15. Schajowicz F. Tumors and Tumorlike Lesions of Bone (2nd edn). Springer-Verlag: Berlin, 1994.
16. Holtzer H, Abbott J, Lash JW, Holtzer S. The loss of phenotypic traits by differentiated cells in vitro, I. Dedifferentiation of cartilage cells. Proc Natl Acad Sci U S A 1960; 46: 1533-1542.
17. Benya PD, Padilla SR, Nimni ME. Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture. Cell 1978; 15: 1313-1321.
18. Benya PD, Padilla SR, Nimni ME. The progeny of rabbit articular chondrocytes synthesize collagen types I and III and type I trimer, but not type II. Verifications by cyanogen bromide peptide analysis. Biochemistry 1977; 16: 865-872.
19. Bovée JVMG, Cleton-Jansen A-M, Rosenberg C, Taminiau AHM, Cornelisse CJ, Hogendoorn PCW. Molecular genetic characterization of both componenets of a dedifferentiated chondrosarcoma, with implications for its histogenesis. J Pathol 1999; 189: 454-462.
20. Tarkkanen M, Wiklund T, Virolainen M, Elomaa I, Knuutila S. Dedifferentiated chondrosarcoma with t(9;22)(q34:q11-12). Genes Chromosomes Cancer 1994; 9: 136-140.
21. Sawyer JR, Swanson CM, Lukacs JL, Nicholas RW, North PE, Thomas JR. Evidence of an association between 6q13-21 chromosome aberrations and locally aggressive behavior in patients with cartilage tumors. Cancer 1998; 82: 474-483.
22. Bridge JA, DeBoer J, Travis J, et al. Simultaneous interphase cytogenetic analysis and fluorescence immunophenotyping of dedifferentiated chondrosarcoma. Am J Pathol 1994; 144: 215-220.
23. Zalupski MM, Ensley JFRJ, Selvaggi S, Baker LH, Wolman SR. A common cytogentic abnormality and DNA content alterations in dedifferentiated chondrosarcoma. Cancer 1990; 66: 1176-1182.
24. Swarts SJ, Neff JR, Johansson SL, Bridge JA. Cytogenetic analysis of dedifferentiated chondrosarcoma. Cancer Genet Cytogenet 1996; 89: 49-51.
25. Tarkkanen M, Kaipaien-A, Karaharju E. Cytogenetic study of 249 consecutive patients examined for a bone tumor. Cancer Genet Cytogenet 1993; 68: 1-21.
26. Ozisik YY, Meloni AM, Peier A, et al. Cytogenetic findings in 19 malignant bone tumors. Cancer 1994; 74: 2268-2275.
27. Roach HI, Erenpreisa J, Aigner T. Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis. J Cell Biol 1995; 131: 483-494.
28. Galotto M, Campanile G, Robino G, Cancedda FD, Bianco P, Cancedda R. Hypertrophic chondrocytes undergo further differentiation to osteoblast-like cells and participate in the initial bone formation in developing chick embryo. J Bone Miner Res 1994; 9: 1239-1249.
29. Simms WW, Ordónez NG, Johnston D, Ayala AG, Czerniak B. p53 expression in dedifferentiated chondrosarcoma. Cancer 1995; 76: 223-227.