D1 agonist and/or D2 antagonist dopamine receptor properties of a series of ergoline derivatives: A structure-activity study

European Journal of Medicinal Chemistry

Volumn 34, Issue 2, 1999, Pages 107-124

  Mantegani, Sergio ^a   Arlandini, Emanuele ^a   Bandiera, Tiziano ^a   Borghi, Daniela ^a   Brambilla, Enzo ^a   Caccia, Carla ^a   Cervini, Maria Antonietta ^a   Cremonesi, Paolo ^a   McArthur, Robert Albert ^a   Traquandi, Gabriella ^a   Varasi, Mario ^a  

^a PFIZER INC   (United States)

Author keywords

Antidopaminergic activity; Dopaminergic; Ergoline derivatives; Structure affinity relationship

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; 8BETA (3,5 DIOXOPIPERAZIN 1 YLMETHYL) 2 BROMO 9,10 DIDEHYDRO 6 METHYLERGOLINE; 8BETA (3,5 DIOXOPIPERAZIN 1 YLMETHYL) 2 CHLORO 9,10 DIDEHYDRO 6 METHYLERGOLINE; 8BETA (3,5 DIOXOPIPERAZIN 1 YLMETHYL) 2 METHYLTHIO 9,10 DIDEHYDRO 6 METHYLERGOLINE; 8BETA (3,5 DIOXOPIPERAZIN 1 YLMETHYL) 9,10 DIDEHYDRO 1,6 DIMETHYL METHYLERGOLINE; 8BETA (3,5 DIOXOPIPERAZIN 1 YLMETHYL) 9,10 DIDEHYDRO 6 METHYLERGOLINE; APOMORPHINE; DOPAMINE; DOPAMINE RECEPTOR; ERGOLINE DERIVATIVE; NITROGEN; PNU 160260; UNCLASSIFIED DRUG; [8BETA (3,5 DIOXO 4 PHENYLPIPERAZIN 1 YL) METHYL] 9,10 DIDEHYDRO 6 METHYLERGOLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLIMBING; CORPUS STRIATUM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FRONTAL CORTEX; HIPPOCAMPUS; MALE; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032716190     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80045-2     Document Type: Article

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