Human FRAG1 encodes a novel membrane-spanning protein that localizes to chromosome 11p15.5, a region of frequent loss of heterozygosity in cancer

Genomics

Volumn 62, Issue 1, 1999, Pages 59-66

  Lorenzi, Matthew V ^a   Castagnino, Paola ^a   Aaronson, Daniel C ^a   Lieb, David C ^a   Lee, Chong Chou ^a   Keck, Catherine L ^a   Popescu, Nicholas C ^a   Miki, Toru ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MEMBRANE PROTEIN;

ARTICLE; CANCER; CARCINOGENESIS; CHROMOSOME 11P; CHROMOSOME ANALYSIS; DNA DETERMINATION; DNA SEQUENCE; GENE INSERTION; GENE LOCATION; GENE MAPPING; GENE STRUCTURE; GENOME; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE ANALYSIS;

RODENTIA;

EID: 0032715975     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1999.5980     Document Type: Article

References (35)

1. Altschul S. F., Gish W., Miller W., Myers E. W., Lipman D. J. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410.
2. Bepler G., O'Briant K. C., Kim Y. C., Schreiber G., Pitterle D. M. A 1.4 Mb high resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region. Genomics. 55:1999;164-175.
3. Bhat G. J., Koslowsky D. J., Feagin J. E., Smiley B. L., Stuart K. An extensively edited mitochondrial transcript in kinetoplastids encodes a protein homolgous to ATPase subunit 6. Cell. 61:1990;885-894.
4. de The H., Chomienne C., Lanotte M, Degos L., Dejean A. The t(15:17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor a gene to a novel transcribed locus. Nature. 347:1990;558-561.
5. Druker B. J., Tamura S., Buchdunger E., Ohno S., Segal G. M., Fanning S., Zimmermann J., Lydon N. B. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 2:1996;561-566.
6. Engelman D. M., Steitz T. A., Goldman A. Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins. Annu. Rev. Biophys. Biophys. Chem. 15:1986;321-353.
7. Feinberg A. P. Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer: An introduction. Cancer Res. 59:1999;1743-1746.
8. Finch P. W., Rubin J. S., Miki T., Ron D., Aaronson S. A. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science. 245:1989;752-755.
9. Gao J. L., Chen H., Filie J. D., Kozak C. A., Murphy P. M. Differential expression of the N-formylpeptide receptor gene cluster in human and mouse. Genomics. 51:1998;270-276.
10. Golub T. R., Barker G. F., Lovett M., Gilliland D. G. Fusion of PDGF receptor to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 77:1994;307-316.
11. Groffen J., Stephenson J. R., Heisterkamp N., de Klein A., Bartram C. R., Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell. 36:1984;93-99.
12. Greco A., Pierotti M. A., Bongarzone I., Pagliardini S., Lanzi C., Della Porta G. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene. 7:1992;237-242.
13. Hudson T. J., Stein L. D., Gerety S. S., Ma J., Castle A. B., Silva J., Slonim D. K., Baptista R. An STS-based map of the human genome. Science. 270:1995;1945-1954.
14. Jankowski S. A., Mitchell D. S., Smith S. H., Trent J. M., Meltzer P. S. SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. Oncogene. 9:1994;1205-1211.
15. Jekabsons W., Schuster W. orf250 encodes a second subunit of an ABC type heme transporter in Oenothera mitochondria. Mol. Gen. Genet. 246:1995;166-173.
16. Jiang S., Hemann M. A., Lee M. P., Feinberg A. P. Strain-dependent developmental relaxation of imprinting of an endogenous mouse gene, KvLQT1. Genomics. 53:1998;395-399.
17. Ketchum K. A., Joiner W. J., Sellers A. J., Kaczmarek L. K., Goldstein S. A. N. A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature. 376:1995;690-695.
18. Koufos A., Grundy P., Morgan K., Aleck K. A., Hadro T., Lampkin B. C., Kalbakji A., Cavenee W. K. Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5. Am. J. Hum. Genet. 44:1989;711-719.
19. Kyte J., Doolittle R. F. A simple method for displaying the hydrophathic character of a protein. J. Mol. Biol. 157:1982;105-132.
20. Lee M. P., Feinberg A. P. Genomic imprinting of a human apoptosis gene homologue, TSSC3. Cancer Res. 58:1998;1052-1056.
21. Lorenzi M. V., Long J. E., Miki T., Aaronson S. A. Expression cloning, developmental expression and chromosomal localization of fibroblast growth factor-8. Oncogene. 10:1995;2051-2055.
22. Lorenzi M. V., Horii Y., Yamanaka R., Sakaguchi K., Miki T. FRAG1, a gene that potently activates fibroblast growth factor receptor by C-terminal fusion through chromosomal rearrangement. Proc. Natl. Acad. Sci. USA. 93:1996;8956-8961.
23. Lorenzi M. V., Castagnino P., Chen Q., Chedid M., Miki T. Ligand independent activation of fibroblast growth factor receptor 2 by carboxyl terminal alterations. Oncogene. 15:1997;817-826.
24. Martin C. H., Mayeda C. A., Davis C. A., Ericsson C. L., Knafels J. D., Mathog D. R., Celniker S. E., Lewis E. B., Palazzolo M. J. Complete sequence of the bithorax complex of Drosophila. Proc. Natl. Acad. Sci. USA. 92:1995;8398-8402.
25. Matsuoka S., Thompson J. S., Edwards M. C., Barletta J. M., Grundy P., Kalikin L. M., Harper J. W., Elledge S. J., Feinberg A. P. Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. Proc. Natl. Acad. Sci. USA. 93:1996;3026-3030.
26. McKusick V. A., Amberger J. S. The morbid anatomy of the human genome: Chromosomal localization of mutations causing disease. Med. Genet. 30:1993;1-26.
27. Miki T., Aaronson S. A. Isolation of oncogenes by expression cDNA cloning. Methods Enzymol. 254:1995;196-206.
28. Park M., Dean M., Cooper C. S., Schmidt M., O'Brien S. J., Blair D. G., Vande Woude G. F. Mechanism of met oncogene activation. Cell. 45:1986;895-904.
29. Ping A. J., Reeve A. E., Law D. J., Young M. R., Boehnke M., Feinberg A. P. Genetic linkage of Beckwith-Wiedemann syndrome to 11p15. Am. J. Hum. Genet. 44:1989;720-723.
30. Popescu N., Zimonjic D., Hatch C., Bonner W. Chromosomal mapping of the human histone gene H2AZ to 4q24 by fluorescence in situ hybridization. Genomics. 20:1994;333-335.
31. Rees S., den Daas I., Foord S., Goodson S., Bull D., Kilpatrick G., Lee M. Cloning and characterization of the human 5-HT5A serotonin receptor. FEBS Lett. 355:1994;242-246.
32. Soman N. R., Correa P., Ruiz B. A., Wogan G. N. The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions. Proc. Natl. Acad. Sci. USA. 88:1991;4892-4896.
33. Trent J. M., Kaneko Y., Mitelman F. Report of the committee on structural chromosomal changes in neoplasia. Human Gene Mapping 10: Tenth International Workshop on Human Gene Mapping. Cytogenet. Cell Genet. 51:1989;533-563.
34. Weksberg R., Shen D. R., Fei Y. L., Song Q. L., Squire J. Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome. Nat. Genet. 5:1993;143-150.
35. Zimonjic D. B., Rezanka L., DiPaolo J. A., Popescu N. C. Refined localization of the erbB3 proto-oncogene by direct visualization of FISH signals on LUT-inverted and contrast-enhanced digital images of DAPI-banded chromosomes. Cancer Genet. Cytogenet. 80:1995;100-102.