Cytotoxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, produces cataract in DBA2 mice

Journal of Ocular Pharmacology and Therapeutics

Volumn 15, Issue 6, 1999, Pages 537-545

  Qian, Wei ^a   Amin, Rajesh H ^a   Shichi, Hitoshi ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 ISOENZYME; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; PROPYLENE GLYCOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME INDUCTION; EYE TOXICITY; HISTOPATHOLOGY; INTRACAMERAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; TOXICITY TESTING;

EID: 0032715587     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.1999.15.537     Document Type: Article

References (19)

1. Boelsterli, U.A. Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury. Drug Metab. Rev. 25:395-451, 1993.
2. Holtzman, J.L. The role of covalent binding to microsomal proteins in the hepatotoxicity of acetaminophen. Drug Metab. Rev. 27:277-297, 1995.
3. Trumper, L., Monasterolo, L.A. and Elias, M.M. Probenecid protects against in vitro acetaminophen-induced nephrotoxicity in male Wistar rats. J. Pharmacol. Exper. Ther. 284:606-610, 1998.
4. Shichi, H., Gaasterland, D.E., Jensen, N.M. and Nebert, D.W. The Ah locus: genetic differences in susceptibility to cataracts induced by acetaminophen. Science 200:539-541, 1978.
5. Lubek, B.M, Avaria, M., Basu, P.K. and Wells, P.G. Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. Fund. Appl. Toxicol. 10:596-606, 1988.
6. Raucy, J.L., Lasker, J.M., Lieber, C.S. and Black, M. Acetaminophen activation by human liver cytochromes P450 2E1 and P450 1A2. Arch. Biochem. Biophys. 271:270-283, 1989.
7. Zhao, C. and Shichi, H. Histocytological study on the possible mechanism of acetaminophen cataractogenesis in mouse eye. Exp. Mol. Pathol. 63:118-128, 1995.
8. Zhao, C., Xiong, Y. and Shichi, H. Acetaminophen cytotoxicity in mouse eye: Mitochondria in anterior tissues are the primary target. J. Ocul. Pharmacol. Ther. 13:269-276, 1997.
9. Shichi, H., Atlas, S.A. and Nebert, D.W. Genetically regulated aryl hydrocarbon hydroxylase induction in the eye: Possible significance of the drug-metabolizing enzyme system for the retinal pigmented epithelium-choroid. Exp. Eye Res. 21:557-567, 1975.
10. Nebert, D.W., Puga, A. and Vasiliou, V. Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction. Ann. NY Acad. Sci. 685:624-640, 1993.
11. Swanson, H.J. and Bradfield, C.A. The Ah-receptor: genetics, structure and function. Pharmacogenetics 3:213-230, 1993.
12. Burcham, P.C. and Harman, A.W. Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes. J. Biol. Chem. 266:5049-5054, 1991.
13. Schanne, F.A.X., Kane, A.B., Young, E.E. and Farber, J.L. Calcium dependence of toxic cell death: A final common pathway. Science 206:700-702, 1979.
14. 2+ in cell killing. Chem. Res. Toxicol. 3:484-494, 1990.
15. Farber, J.L. The role of calcium in lethal cell injury. Chem. Res. Toxicol. 3:503-508, 1990.
16. 2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. FASEB J. 7:453-463, 1993.
17. Hightower, K.R. Cytotoxic effects of internal calcium on lens physiology: A review. Curr. Eye Res. 4:453-459, 1985.
18. Siew, E.L. and Bettelheim, F.A. Light scattering parameters of rat lenses with calcium-induced cataracts. Exp. Eye Res. 62:265-270, 1996.
19. Lo, A.C., Houenou, L.J. and Oppenheim, R.W. Apoptosis in the nervous system: Morphological features, methods, pathology, and prevention. Arch. Histol. Cytol. 58:139-149, 1995.