A small sodium channel blocking factor in the cerebrospinal fluid is preferentially found in Guillain-Barre syndrome: A combined cell physiological and HPLC study

Journal of Neurology

Volumn 246, Issue 10, 1999, Pages 955-960

  Weber, Frank ^a   Brinkmeier, Heinrich ^c   Aulkemeyer, Peter ^c   Wollinsky, Kurt H ^b   Rüdel, Reinhardt ^c  

^a Military Hospital   (Germany)

^b Rehabilitationskrankenhaus Ulm gGmbH   (Germany)

^c NONE

Author keywords

Conduction block; Demyelination; Guillain Barre syndrome; Inflammation; Sodium channel

Indexed keywords

SODIUM CHANNEL BLOCKING AGENT;

ARTICLE; CELL FUNCTION; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; ELECTROPHYSIOLOGY; GLIOMA CELL; GUILLAIN BARRE SYNDROME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MOLECULAR WEIGHT; NEUROBLASTOMA; NEUROLOGIC DISEASE; PRIORITY JOURNAL;

CEREBROSPINAL FLUID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEMYELINATING DISEASES; ELECTROPHYSIOLOGY; GUILLAIN-BARRE SYNDROME; HUMANS; MOLECULAR WEIGHT; NERVOUS SYSTEM DISEASES; NEURONS; SODIUM CHANNEL BLOCKERS; TUMOR CELLS, CULTURED;

EID: 0032714475     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004150050490     Document Type: Article

References (22)

1. + channel blocking factor in the CSF. Pflugers Arch 435 [Suppl]: R: 140
2. Aulkemeyer P, Brinkmeier H, Wollinsky KH, Rüdel R (1996) The human endogenous local anaesthetic-like factor (ELLF) is functionally neutralized by serum albumin. Neurosci Lett 216: 37-40
3. Benatar M, Willison HJ, Vincent A (1999) Immune-mediated peripheral neuropathies and voltage-gated sodium channels. Muscle Nerve 22: 108-110
4. Brinkmeier H, Seewald MJ, Wollinsky KH, Rüdel R (1996) On the nature of endogenous antiexcitatory factors in the cerebrospinal fluid of patients with demyelinating neurological disease. Muscle Nerve 19: 54-62
5. + channel blocking factor in the cerebrospinal fluid. Pflugers Arch 421: 552-557
6. Davie CA, Barker GJ, Webb S, Tofts PS, Thompson AJ, Harding AE, McDonald WI, Miller DH (1995) Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain 118: 1583-1592
7. Fishman RA (1992) Cerebrospinal fluid in diseases of the nervous system, 2nd edn. Saunders, Philadelphia
8. Hartung HP, Pollard JD, Harvey GK, Toyka KV (1995) Immunopathogenesis and treatment of the Guillain-Barre syndrome. I. Muscle Nerve 18: 137-153
9. Hartung HP, Pollard JD, Harvey GK, Toyka KV (1995) Immunopathogenesis and treatment of the Guillain-Barre syndrome. II. Muscle Nerve 18: 154-164
10. Hirota N, Kaji R, Bostock H, Shindo K, Kawasaki T, Mizutani K, Oka N, Kohara N, Saida T, Kimura J (1997) The pysiological effect of anti-GM1 antibodies on saltatory conduction and transmembrane currents in single motor axons. Brain 120: 2159-2169
11. Hughes RAC (1995) Guillain-Barré Syndrome and chronic inflammatory demyelinating polyneuropathy. In: Asbury AK, Thomas PK (eds) Guillain-Barré syndrome and chronic inflamm atory demyelinating polyneuropathy, vol 1. Butterworth-Heinemann, Oxford, pp 175-204
12. + current. Brain 119: 457-463
13. Köller H, Siebler M, Hartung H-P (1997) Immunologically induced electrophysiological dysfunction: implications for inflammatory diseases of the CNS and PNS. Progress Neurobiol 52: 1-26
14. Kuwabara S, Asahina M, Koga M, Mori M, Yuki N, Hattori T (1998) Two patterns of clinical recovery in Guillain-Barré syndrome with IgG anti-GM1 antibody. Neurology 51: 1656-1660
15. Kuwabara S, Yuki N, Koga M, Hattori T, Matsuura D, Miyake M, Noda M (1998) IgG Anti-GM1 antibody is associated with reversible conduction failure and axonal degeneration in Guillain-Barré syndrome. Ann Neurol 44: 202-208
16. Madeja M, Speckmann E-J (1997) The fraction of active sodium channel involved in the generation of action potentials (abstract). Pflugers Arch 433 [Suppl]: O-139
17. McDonald WI, Sears TA (1970) The effects of experimental demyelination on conduction in the central nervous system. Brain 93: 583-598
18. Powell HC, Myers RR (1996) The Axon in Guillain-Barré syndrome: immune target or innocent bystander? Ann Neurol 39: 4-5
19. + channels, expressed in a mammalian cell line, by local anaesthetic, antiarrhythmic, and anticonvulsive drugs. Molecular Pharmacology 40: 756-765
20. + currents in isolated rat myelinated nerve fibers. Ann Neurol 37: 436-442
21. Waxman S (1995) Sodium channel blockade by antibodies: a new mechanism of neurological disease? Ann Neurol 37: 421-423
22. Würz A, Brinkmeier H, Wollinsky KH, Mehrtens HH, Kornhuber HH, Rüdel R (1995) Cerebrospinal fluid and serum from patients with inflammatory poly-radiculoneuropathy have opposite effects on sodium channels. Muscle Nerve 18: 772-781