Subchronically applied phencyclidine fails to disrupt prepulse inhibition in rats

European Neuropsychopharmacology

Volumn 10, Issue 1, 1999, Pages 69-74

  Ehrhardt, Jens ^a   Sabel, Bernhard A ^a   Schroeder, Ulrike ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Acoustic startle; Controlled release; Psychosis; Sensitization

Indexed keywords

PHENCYCLIDINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG IMPLANT; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; STARTLE REFLEX; SUBCUTANEOUS DRUG ADMINISTRATION;

ACOUSTIC STIMULATION; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DRUG IMPLANTS; HABITUATION, PSYCHOPHYSIOLOGIC; HALLUCINOGENS; INJECTIONS, INTRAPERITONEAL; MALE; NEURAL INHIBITION; PHENCYCLIDINE; PSYCHOSES, SUBSTANCE-INDUCED; RATS; RATS, INBRED STRAINS; STARTLE REACTION;

EID: 0032714450     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(99)00058-9     Document Type: Article

References (18)

1. Adams B., Moghaddam B. Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine. J. Neurosci. 18:1998;5545-5554.
2. Carlsson M., Carlsson A. Interactions between glutamatergic and monoaminergic systems within the basal ganglia- implications for schizophrenia and Parkinson's disease. Tr. Neurosci. 13:1990;272-276.
3. Castellani S., Giannini A.J., Adams P.M. Physostigmine and haloperidol treatment of acute phencyclidine intoxication. Am. J. Psych. 139:1982;508-510.
4. Ellenbroek B.A., Cools A.R. The neurodevelopment hypothesis of schizophrenia: Clinical evidence and animal models. Neurosci. Res. Com. 22:1998;127-136.
5. French E.D. Phencyclidine and the midbrain dopamine system: electrophysiology and behavior. Neurotoxiol. Teratol. 4:1994;355-362.
6. Haik-Creguer K.L., Dunbar G.L., Sabel B.A., Schroeder U. Small drug sample fabrication of controlled release polymers using the microextrusion method. J. Neurosci. Meth. 80:1998;37-40.
7. Javitt D.C. Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia. Hillside J. Clin. Psych. 9:1987;12-35.
8. Javitt D.C., Schroeder C.E., Steinschneider M., Arezzo J.C., Ritter W., Vaughan H.G. Jr. Cognitive event-related potentials in human and non-human primates: implications for the PCP/NMDA model of schizophrenia. Electroenceph. Clin. Neurophysiol. Suppl. 44:1995;161-175.
9. Jentsch J.D., Tran A., Le D., Youngren K.D., Roth R.H. Subchronic phencyclidine administration reduces mesoprefrontal dopamine utilization and impairs prefrontal cortical-dependent cognition in the rat. Neuropsychopharmacology. 17:1997;92-99.
10. Koch M., Schnitzler H.U. The acoustic startle response in rats-circuits mediating evocation, inhibition and potentiation. Behav. Brain Res. 89:1997;35-49.
11. Mansbach R.S., Geyer M.A. Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuropsychopharmacology. 2:1989;299-308.
12. Olney J.W., Farber N.B. Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Psychiatry. 52:1995;998-1007.
13. Pilz P.K.D., Schnitzler H.U. Habituation and sensitization of the acoustic startle response in rats: amplitude, threshold, and latency measures. Neurobiol. Learn. Mem. 66:1996;67-79.
14. Rainey J.M. Jr., Crowder M.K. Prolonged psychosis attributed to phencyclidine: report of three cases. Am. J. Psychiatry. 132:1975;1076-1078.
15. Schroeder U., Schroeder H., Darius J., Grecksch G., Sabel B.A. Simulation of psychosis by continuous delivery of phencyclidine from controlled-release polymer implants. Behav. Brain. Res. 97:1998;59-68.
16. Schwegler H., Pilz P.K., Koch M., Fendt M., Linke R., Driscoll P. The acoustic startle response in inbred Roman high- and low-avoidance rats. Behav. Genet. 27:1997;579-582.
17. Steinpreis R. The behavioral and neurochemical effects of phencyclidine in humans and animals: some implications for modeling psychosis. Behav. Brain Res. 74:1996;45-55.
18. Steinpreis R.E., Salomone J.D. The role of nucleus accumbens dopamine in neurochemical and behavioral effects of phencyclidine: a microdialysis and behavioral study. Brain Res. 612:1993;263-270.