Effects of K+ channel inhibitors on relaxation induced by flufenamic and tolfenamic acids in guinea-pig trachea

European Journal of Pharmacology

Volumn 383, Issue 2, 1999, Pages 169-176

  Li, Liang ^a   Vaali, Kirsi ^a   Vapaatalo, Heikki ^a   Kankaanranta, Hannu ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Fenamate; Guinea pig; K+ channel; Relaxation; Smooth muscle; Trachea

Indexed keywords

4 AMINOPYRIDINE; APAMIN; CALCIUM ION; FENAMIC ACID DERIVATIVE; FLUFENAMIC ACID; GLIBENCLAMIDE; IBERIOTOXIN; INDOMETACIN; LEMAKALIM; NIFEDIPINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROSTAGLANDIN F2 ALPHA; TOLFENAMIC ACID;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; FEMALE; GUINEA PIG; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE;

ANIMALS; ANTHRANILIC ACIDS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CROMAKALIM; DINOPROST; FEMALE; FLUFENAMIC ACID; GUINEA PIGS; INDOMETHACIN; MALE; MUSCLE RELAXATION; NIFEDIPINE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; TRACHEA;

EID: 0032714172     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00634-2     Document Type: Article

References (53)

1. Advenier C., Cerrina J., Duroux P., Floch A., Renier A. Effects of five different organic calcium antagonists on guinea-pig isolated trachea. Br. J. Pharmacol. 82:1984;727-733.
2. Allen S.L., Boyle J.P., Cortijo J., Foster R.W., Morgan G.P., Small R.C. Electrical and mechanical effects of BRL 34915 in guinea-pig isolated trachealis. Br. J. Pharmacol. 89:1986;395-405.
3. Bennett A., Pratt D., Sanger G.J. Antagonism by fenamates of prostaglandin action in guinea-pig and human alimentary muscle. Br. J. Pharmacol. 68:1980;357-362.
4. Black J.L., Armour C.L., Johnson P.R., Alouan L.A., Barnes P.J. The action of a potassium channel activator, BRL 38227 (lemakalim), on human airway smooth muscle. Am. Rev. Respir. Dis. 142:1990;1384-1389.
5. Boyle J.P., Tomas M., Kotlikoff M.I. Delayed rectifier potassium channels in canine and porcine airway smooth muscle cells. J. Physiol. 447:1992;329-350.
6. Buckle D.R., Arch J.R., Bowring N.E., Foster K.A., Taylor J.F., Taylor S.G., Shaw D.J. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660. Pulm. Pharmacol. 6:1993;77-86.
7. Castle N.A., Haylett D.G. Effects of channel blockers on potassium efflux from metabolically exhausted frog skeletal muscle. J. Physiol. 383:1987;31-43.
8. Conroy M.C., Randinitis E.J., Turner J.L. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin. J. Pain. 7(Suppl. 1):1991;S44-S48.
9. Cook S.J., Archer K., Martin A., Buchheit K.H., Fozard J.R., Muller T., Miller A.J., Elliott K.R., Foster R.W., Small R.C. Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40. Br. J. Pharmacol. 114:1995;143-151.
10. Famaey J.P., Fotaine J., Reuse J. Effect of high concentrations of non-steroidal and steroidal anti-inflammatory drugs on prostaglandin-induced contractions of the guinea-pig isolated ileum. Prostaglandins. 13:1977;107-114.
11. Farrugia G., Rae J.L., Sarr M.G., Szurszewski J.H. Potassium current in circular smooth muscle of human jejunum activated by fenamates. Am. J. Physiol. 265:1993;G873-G879.
12. Farrugia G., Rae J.L., Szurszewski J.H. Characterization of an outward potassium current in canine jejunal circular smooth muscle and its activation by fenamates. J. Physiol. 468:1993;297-310.
13. Fleischmann B.K., Washabau R.J., Kotlikoff M.I. Control of resting membrane potential by delayed-rectifier potassium currents in ferret airway smooth muscle cells. J. Physiol. 469:1993;25-638.
14. Fleischmann B.K., Hay D.W.P., Kotlikoff M.I. Control of basal tone by delayed rectifier potassium channels in human airways. Am. Rev. Respir. Dis. 149:1994;A1080.
15. Foster R.W., Okpalugo M.I., Small R.C. Antagonism of calcium and other actions of verapamil in guinea-pig isolated trachea. Br. J. Pharmacol. 81:1984;499-507.
16. Galvez A., Gimenez-Gallego G., Reuben J.P., Roy-Contancin L., Feigenbaum P., Kaczorowski G.J., Garcia M.L. Purification and characterization of a unique, potent, peptidyl probe for the high conductance, calcium-activated potassium channel from venom of the scorpion, Buthus tamulus. J. Biol. Chem. 265:1990;11083-11090.
17. Gögelein H., Dahlem D., Englert H.C., Lang H.J. Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas. FEBS Lett. 268:1990;79-82.
18. Greenwood I.A., Large W.A. Comparison of the effects of the fenamates on Ca-activated chloride and potassium currents in rabbit portal vein smooth muscle cells. Br. J. Pharmacol. 116:1995;2939-2948.
19. Haworth R.A., Goknur A.B., Berkoff H.A. Inhibition of ATP-sensitive potassium channels of adult rat heart cells by anti-arrhythmic drugs. Circ. Res. 65:1989;1157-1160.
20. Hisada T., Yoshihisa K., Tsuneaki S. Properties of membrane current from guinea-pig trachea. Pflug. Arch. 416:1990;151-161.
21. + channel blockers. Eur. J. Pharmacol. 235:1993;37-43.
22. + channel inhibitors on the electrical behavior of guinea-pig isolated trachealis and on its responses to spasmogenic drugs. Br. J. Pharmacol. 117:1996;1653-1662.
23. Janssen L.J., Sims S.M. Acetylcholine activates non-selective cation and chloride conductances in canine and guinea-pig tracheal myocytes. J. Physiol. 453:1992;197-218.
24. + currents in guinea-pig tracheal myocytes: convergence with muscarinic signaling pathway. J. Physiol. 465:1993;661-677.
25. + conductances in guinea-pig tracheal smooth muscle cells. Can. J. Physiol. Pharmacol. 72:1994;705-710.
26. + channel inhibitor. J. Pharmacol. Exp. Ther. 255:1990;697-706.
27. Jones T.R., Charette L., Garcia M.L., Kaczorowski G.J. Interaction of iberiotoxin with beta-adrenoceptor agonists and sodium nitroprusside on guinea-pig trachea. J. Appl. Physiol. 74:1993;1879-1884.
28. Kakei M., Noma A., Shibasaki T. Properties of adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells. J. Physiol. 363:1985;441-462.
29. Kankaanranta H., Moilanen E. Flufenamic and tolfenamic acids inhibit calcium influx in human polymorphonuclear leukocytes. Mol. Pharmacol. 47:1995;1006-1013.
30. Kankaanranta H., Luomala M., Kosonen O., Moilanen E. Inhibition by fenamates of calcium influx and proliferation of human lymphocytes. Br. J. Pharmacol. 119:1996;487-494.
31. Knox A.J., Tattersfield A.E. Airway smooth muscle. Szekeres L., Papp J.G. Handbook of Experimental Pharmacology. 111:1994;405-443 Springer-Verlag, Berlin.
32. Kotlikoff M.I. Potassium currents in canine airway smooth muscle cells. Am. J. Physiol. 259:1990;L384-L395.
33. Kotlikoff M.I. Potassium channels in airway smooth muscle: a tale of two channels. Pharmacol. Ther. 58:1993;1-12.
34. Kotlikoff M.I., Kamm K.E. Molecular mechanisms of β-adrenergic relaxation of airway smooth muscle. Annu. Rev. Physiol. 58:1996;115-141.
35. - conductance in smooth muscle. Am. J. Physiol. 271:1996;C435-C454.
36. Li L., Vaali K., Paakkari I., Vapaatalo H. Bradykinin, lemakalim and sodium nitroprusside relax the mouse trachea in vitro by different mechanisms. Life Sci. 61:1997;PL67-PL73.
37. Li L., Vapaatalo H., Vaali K., Paakkari I., Kankaanranta H. Fenamates inhibit contraction of guinea-pig isolated bronchus in vitro independent of prostanoid synthesis inhibition. Life Sci. 62:1998;PL289-PL294.
38. Lindén I., Parantainen J., Vapaatalo H. Inhibition of prostaglandin biosynthesis by tolfenamic acid in vitro. Scand. J. Rheum. 5:1976;129-132.
39. Marmy N., Mottas J., Durand J. Signal transduction in smooth muscle cells from human airways. Respir. Physiol. 91:1993;295-306.
40. Marthan R., Martin C., Amedee T., Mirroneau J. Calcium channel currents in isolated smooth muscle cells from human bronchus. J. Appl. Physiol. 66:1989;1706-1714.
41. Mclean J.R., Gluckman M.I. On the mechanism of the pharmacological activity of meclofenamate sodium. Drug Res. 33:1983;627-631.
42. Miura M., Belvisi M.G., Stretton C.D., Yacoub M.H., Barnes P.J. Role of potassium channels in bronchodilator responses in human airways. Am. Rev. Respir. Dis. 146:1992;132-136.
43. Moilanen E., Kankaanranta H. Tofenamic acid and leukotriene synthesis inhibition. Pharmacol. Toxicol. 75(Suppl. 2):1994;60-63.
44. Muraki K., Imaizumi Y., Kojima T., Kawai T., Watanabe M. Effects of tetraethylammonium and 4-aminopyridine on outward currents and excitability in canine tracheal smooth muscle cells. Br. J. Pharmacol. 100:1990;507-515.
45. + channels. Br. J. Pharmacol. 98:1991;865-874.
46. Ca channels by niflumic, flufenamic and mefenamic acid. Biophys. J. 67:1994;2272-2279.
47. Rae J.L., Farrugia G. Whole-cell potassium current in rabbit corneal epithelium activated by fenamates. J. Membr. Biol. 129:1992;81-97.
48. Sanger G.J., Bennett A. Fenamates may antagonize the actions of prostaglandin endoperoxides in human myometrium. Br. J. Clin. Pharmacol. 8:1979;482-497.
49. +-channel opening in mediating their bronchodilator effects. Clin. Exp. Allergy. 23:1993;802-811.
50. Urquhart R.A., Broadley K.J. Blockade by 4-AP of the muscarinic receptor responses of guinea-pig atria and trachea. J. Pharm. Pharmacol. 43:1991;417-420.
51. Vane J., Botting R. Overview - mechanisms of action of anti-inflammatory drugs. Vane J., Botting J., Botting R. Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. 1996;1-27 Kluwer Academic Publishers and William Harvey Press, London.
52. Vapaatalo H., Parantainen J., Linden I.-B., Hakkarainen H. Prostaglandins and vascular headache. Action of tolfenamic acid, a new anti-inflammatory analgesic, on migraine. Scooter F. Headache, New Vistas. 1977;287-300 Biochemical Press, Florence.
53. + currents in canine coronary artery smooth muscle cells by NS-004, or 1-(2′-hydroxy-5′-chlorophenyl-5-trifluoromethyl-2(3H benzimidazolone. J. Pharmacol. Exp. Ther. 271:1994;362-369.