Effects of bilobalide, a sesquiterpene in Ginkgo biloba leaves, on population spikes in rat hippocampal slices

Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology

Volumn 124, Issue 3, 1999, Pages 315-321

  Sasaki, Keiko ^a   Oota, Isao ^b   Wada, Keiji ^a   Inomata, Kotaro ^b   Ohshika, Hideyo ^c   Haga, Masanobu ^a  

^a Tohoku University   (Japan)

^b HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^c SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bilobalide; Excitability; Ginkgo biloba; Hippocampus; Paired pulse inhibition; Population spikes; Pyramidal neuron; Rat

Indexed keywords

BILOBALIDE; GINKGO BILOBA EXTRACT; MUSCIMOL; SESQUITERPENE;

ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GINKGO BILOBA; HIPPOCAMPUS; MALE; NERVE CELL EXCITABILITY; NERVE CELL INHIBITION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SPIKE;

ACTION POTENTIALS; ANIMALS; CYCLOPENTANES; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; FURANS; GABA AGONISTS; GINKGO BILOBA; GINKGOLIDES; HIPPOCAMPUS; MALE; MUSCIMOL; NEURONS; PLANT LEAVES; PLANTS, MEDICINAL; PYRAMIDAL CELLS; RATS; RATS, WISTAR; SESQUITERPENES;

EID: 0032714101     PISSN: 07428413     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0742-8413(99)00082-1     Document Type: Article

References (26)

1. Ahlemeyer B., Möwes A., Krieglstein J. Inhibition of serum deprivation- and staurosporine-induced neuronal apoptosis by Ginkgo biloba extract and some of its constituents. Eur. J. Pharmacol. 367:1999;423-430.
2. Alger B.E., Nicoll R.A. Feed-forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro. J. Physiol. 328:1982;105-123.
3. Andersen P., Bliss T.V.P., Skrede K.K. Unit analysis of hippocampal population spikes. Exp. Brain Res. 13:1971;208-221.
4. Andersen P., Sundberg S.H., Sveen O., Wigström H. Specific long-lasting potentiation of synaptic transmission in hippocampal slices. Nature. 266:1977;736-737.
5. Berger T.W. Long-term potentiation of hippocampal synaptic transmission affects rate of behavioral learning. Science. 224:1984;627-630.
6. Braquet P., Esanu A., Buisine E., Hosford D., Broquet C., Koltai M. Recent progress in ginkgolide research. Med. Res. Rev. 11:1991;295-355.
7. Bruno C., Cuppini R., Sartini S., Cecchini T., Ambrogini P., Bombardelli E. Regeneration of motor nerves in bilobalide-treated rats. Planta Med. 59:1993;302-307.
8. Chatterjee SS, Gabard BL, Jaggy HEW. Pharmaceutical compositions containing bilobalide for the treatment of neuropathies. US patent No. 4,571,407 (February 18, 1986).
9. Davies C.H., Davies S.N., Collingridge G.L. Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. J. Physiol. 424:1990;513-531.
10. DeFeudis F.V. Pharmacological activities and clinical applications. 1991;147-152 Elsevier, Paris.
11. Ferchmin P.A., Eterovic V.A., Rivera E.M., Teyler T.J. Spermine increases paired-pulse facilitation in area CA1 of hippocampus in a calcium-dependent manner. Brain Res. 689:1995;189-196.
12. Janssens D., Michiels C., Delaive E., Eliaers F., Drieu K., Remacle J. Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and bilobalide. Biochem. Pharmacol. 50:1995;991-999.
13. Joyeux M., Lobstein A., Anton R., Mortier F. Comparative antilipoperoxidant, antinecrotic and scavenging properties of terpenes and biflavones from Ginkgo and some flavonoids. Planta Med. 61:1995;126-129.
14. Kleijnen J., Knipschild P. Ginkgo biloba. Lancet. 340:1992;1136-1139.
15. Krieglstein J., Ausmeier F., EI-Abhar H., Lippert K., Welsch M., Rupalla K. et al. Neuroprotective effects of Ginkgo biloba constituents. Eur. J. Pharm. Sci. 3:1995;39-49.
16. Le Bars P.L., Katz M.M., Berman N., Itil T.M., Freedman A.M., Schatzberg A.F. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. J. Am. Med. Assoc. 278:1997;1327-1332.
17. Moser E.I. Learning-related changes in hippocampal field potentials. Behav. Brain Res. 71:1995;11-18.
18. 20-ginkgolides. J. Am. Chem. Soc. 93:1971;3544-3546.
19. Nathan T., Lambert J.D.C. Depression of the fast IPSP underlies paired-pulse facilitation in area CA1 of the rat hippocampus. J. Neurophysiol. 66:1991;1704-1715.
20. Power J.M., Thompson L.T., Moyer J.R., Disterhoft J.F. Enhanced synaptic transmission in CA1 hippocampus after eyeblink conditioning. J. Neurophysiol. 78:1997;1184-1187.
21. Smith P.F., Maclennan K., Darlington C.L. The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). J. Ethnopharmacol. 50:1996;131-139.
22. Steffensen S.C., Henriksen S.J. Effects of baclofen and bicuculline on inhibition in the fascia dentata and hippocampus regio superior. Brain Res. 538:1991;46-53.
23. Wada K., Sasaki K., Miura K., Yagi M., Kubota Y., Matsumoto T. et al. Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biol. Pharm. Bull. 16:1993;210-212.
24. Weinges K, Hepp M, Huber-Patz U, Rodewald H, Irngartinger H. 10-Acetyl-1-methoxycarbonyl-2,3,14,15,16-Pentanorginkgolid A, ein Zwischenprodukt zur Herstellung von Bilobalid, Liebigs Ann Chem 1986;6:1057-66.
25. Winter E. Effects of an extract of Ginkgo biloba on learning and memory in mice. Pharmacol. Biochem. Behav. 38:1991;109-114.
26. Winter J.C. The effects of an extract of Ginkgo biloba, EGb 761, on cognitive behavior and longevity in the rat. Physiol. Behav. 63:1998;425-433.