Water determination in drugs containing thiols

International Journal of Pharmaceutics

Volumn 190, Issue 2, 1999, Pages 193-196

  Sherman, Felix ^a   Kuselman, Ilya ^a  

^a National Physical Laboratory of Israel   (Israel)

Author keywords

Drugs in tablets; Karl Fischer titration; Thiol determination; Validation; Water determination

Indexed keywords

ACETIC ACID; CAPTOPRIL; GLYCEROL DERIVATIVE; IODINE; POTASSIUM IODIDE; THIOL DERIVATIVE;

ACCURACY; ANALYTIC METHOD; ARTICLE; MOISTURE; OXIDATION; PRIORITY JOURNAL; REPRODUCIBILITY; TITRIMETRY; WATER ANALYSIS;

CAPTOPRIL; GLYCEROL; INDICATORS AND REAGENTS; REPRODUCIBILITY OF RESULTS; TABLETS; WATER;

EID: 0032713262     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00290-2     Document Type: Article

References (9)

1. AOAC, 1993. Peer-Verified Methods Program. AOAC International Arlington, VA, USA.
2. Cheronis N.D., Ma T.S. Organic Functional Group Analysis by Micro and Semimicro Methods. 1964;324 Wiley, New York.
3. Mitchell J. Jr, Smith D.M. second ed. Aquametry. 3:1980;361 Wiley, New York.
4. Sherman F. Microdetermination of polysaccharides and glycoproteins hydration level. Talanta. 31:1983;703-705.
5. Sherman F., Kuselman I. Water determination in drugs containing ascorbic acid. Drug Dev. Pharm. 25(10):1999;43-47.
6. Sherman F., Kuselman I., Shenhar A. Determination of water and ene-diols or thiols in samples inaccessible for K. Fischer titration. Talanta. 43:1996;1035-1042.
7. Sherman, F., Kuselman, I., Shenhar, A., 1996b. Precision and accuracy determination of water and ene-diols or thiols in samples not amenable for direct K. Fischer titration. Proceedings of the 11th Int. Conf. of The Israel Soc. for Quality. Jerusalem, pp. 529-532.
8. Sherman, F., Kuselman, I., Shenhar, A., 1998. Reagent for Determination of Water and Ene-diols or Thiols. U.S. Pat. 57550404.
9. USP, 1995. NF 23 United States Pharmacopoeail Convention, Rockvile, MD, Articles 731, p. 1801 and 921, p. 1840; pp. 263, 960, 2271.