메뉴 건너뛰기




Volumn 12, Issue 11 SUPPL. 1, 1999, Pages

Emerging treatments for hypertension: Potential role for vasopeptidase inhibition

Author keywords

Hypertension; Omapatrilat; Vasopeptidase inhibitors

Indexed keywords

7 (2 MERCAPTOMETHYL 3 PHENYLPROPIONAMIDO)HEPTANOIC ACID; ANGIOTENSIN; ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; LEUCINE THIORPHAN; MEMBRANE METALLOENDOPEPTIDASE; N (2 MERCAPTOMETHYL 3 PHENYLBUTYRYL)ALANINE; N [2 (ACETYLTHIOMETHYL) 3 (2 METHYLPHENYL)PROPIONYL]METHIONINE ETHYL ESTER; N [[1 (2 ACETYLTHIO 3 METHYL 1 OXOBUTYLAMINO) 1 CYCLOPENTYL]CARBONYL] O METHYLTYROSINE ETHYL ESTER; NATRIURETIC FACTOR; OMAPATRILAT; PROTEINASE INHIBITOR; RENIN; UNCLASSIFIED DRUG; VASOPEPTIDASE INHIBITOR;

EID: 0032712735     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0895-7061(99)00205-8     Document Type: Article
Times cited : (56)

References (57)
  • 2
    • 0344222183 scopus 로고    scopus 로고
    • Antihypertensive efficacy of treatment regimens used in Veterans Administration hypertension clinics
    • Perry HMJ, Bingham S, Horney A, Rutan G, Sambhi M, Carmody S, Collins J, for the Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents: Antihypertensive efficacy of treatment regimens used in Veterans Administration hypertension clinics. Hypertension 1998;31:771-779.
    • (1998) Hypertension , vol.31 , pp. 771-779
    • Perry, H.M.J.1    Bingham, S.2    Horney, A.3    Rutan, G.4    Sambhi, M.5    Carmody, S.6    Collins, J.7
  • 3
    • 0033005062 scopus 로고    scopus 로고
    • 1999 World Health Organization-International Society of Hypertension Guidelines for the management of hypertension
    • Guidelines Subcommittee: 1999 World Health Organization-International Society of Hypertension Guidelines for the management of hypertension. J Hypertens 1999;17:151-183.
    • (1999) J Hypertens , vol.17 , pp. 151-183
  • 4
    • 0018856859 scopus 로고
    • Perspectives on systolic hypertension. The Framingham study
    • Kannel WB, Dawber TR, McGee DL: Perspectives on systolic hypertension. The Framingham study. Circulation 1980;61:1179-1182.
    • (1980) Circulation , vol.61 , pp. 1179-1182
    • Kannel, W.B.1    Dawber, T.R.2    McGee, D.L.3
  • 5
    • 0027145058 scopus 로고
    • The natural history of borderline isolated systolic hypertension
    • Sagie A, Larson MG, Levy D: The natural history of borderline isolated systolic hypertension. N Engl J Med 1993;329:1912-1917.
    • (1993) N Engl J Med , vol.329 , pp. 1912-1917
    • Sagie, A.1    Larson, M.G.2    Levy, D.3
  • 6
    • 0029617996 scopus 로고
    • The association between midlife blood pressure levels and late-life cognitive function
    • Launer LJ, Masaki K, Petrovitch H, Foley D, Havlik RJ: The association between midlife blood pressure levels and late-life cognitive function. JAMA 1995;274:1846-1851.
    • (1995) JAMA , vol.274 , pp. 1846-1851
    • Launer, L.J.1    Masaki, K.2    Petrovitch, H.3    Foley, D.4    Havlik, R.J.5
  • 7
    • 0025831464 scopus 로고
    • Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP)
    • SHEP Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991;265:3255-3264.
    • (1991) JAMA , vol.265 , pp. 3255-3264
  • 8
    • 0027517659 scopus 로고
    • The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy
    • published erratum appears in N Engl J Med 1993;330: 152
    • Lewis EJ, Hunsicker LG, Bain RP, Rohde RD, for the Collaborative Study Group: The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy [published erratum appears in N Engl J Med 1993;330: 152]. N Engl J Med 1993;329:1456-1462.
    • (1993) N Engl J Med , vol.329 , pp. 1456-1462
    • Lewis, E.J.1    Hunsicker, L.G.2    Bain, R.P.3    Rohde, R.D.4
  • 9
    • 0001600973 scopus 로고    scopus 로고
    • Aldosterone: New concepts in mechanism of action
    • Williams GH: Aldosterone: new concepts in mechanism of action (abst). Am J Hypertens 1999;12(Pt 2): 226A.
    • (1999) Am J Hypertens , vol.12 , Issue.2 PART
    • Williams, G.H.1
  • 10
    • 4243655424 scopus 로고    scopus 로고
    • Epithelial and non-epithelial effects on mineralocorticoids
    • Funder JW: Epithelial and non-epithelial effects on mineralocorticoids (abst). Am J Hypertens 1999;12(Pt 2):226A.
    • (1999) Am J Hypertens , vol.12 , Issue.2 PART
    • Funder, J.W.1
  • 11
    • 4243723466 scopus 로고    scopus 로고
    • Aldosterone: Antagonists and cardiovascular protection
    • Williams GH: Aldosterone: antagonists and cardiovascular protection (abst). Am J Hypertens 1999;12(Pt 2): 213A.
    • (1999) Am J Hypertens , vol.12 , Issue.2 PART
    • Williams, G.H.1
  • 13
    • 4244092977 scopus 로고    scopus 로고
    • Imidazoline receptor agonist drugs
    • Frishman WH: Imidazoline receptor agonist drugs (abst). Am J Hypertens 1999;12(Pt 2):213A.
    • (1999) Am J Hypertens , vol.12 , Issue.2 PART
    • Frishman, W.H.1
  • 14
    • 0033514321 scopus 로고    scopus 로고
    • Effects of a specific endothelin-converting enzyme inhibitor on cardiac, renal, and neurohumoral functions in congestive heart failure: Comparison of effects with those of endothelin A receptor antagonism
    • Wada A, Tsutamoto T, Ohnishi M, Sawaki M, Fukai D, Maeda Y, Kinoshita M: Effects of a specific endothelin-converting enzyme inhibitor on cardiac, renal, and neurohumoral functions in congestive heart failure: comparison of effects with those of endothelin A receptor antagonism. Circulation 1999;99:570-577.
    • (1999) Circulation , vol.99 , pp. 570-577
    • Wada, A.1    Tsutamoto, T.2    Ohnishi, M.3    Sawaki, M.4    Fukai, D.5    Maeda, Y.6    Kinoshita, M.7
  • 15
    • 0032435964 scopus 로고    scopus 로고
    • Endothelin and endothelin antagonists in hypertension
    • Schiffrin EL: Endothelin and endothelin antagonists in hypertension. J Hypertens 1998;16(Pt 2):1891-1895.
    • (1998) J Hypertens , vol.16 , Issue.2 PART , pp. 1891-1895
    • Schiffrin, E.L.1
  • 16
    • 0028961663 scopus 로고
    • Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia
    • Zeiher AM, Krause T, Schächinger V, Minners J, Moser E: Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. Circulation 1995;91: 2345-2352.
    • (1995) Circulation , vol.91 , pp. 2345-2352
    • Zeiher, A.M.1    Krause, T.2    Schächinger, V.3    Minners, J.4    Moser, E.5
  • 17
    • 0033011038 scopus 로고    scopus 로고
    • Vasopeptidase inhibition: A new concept in blood pressure management
    • Burnett JC Jr: Vasopeptidase inhibition: a new concept in blood pressure management. J Hypertens 1999; 17(suppl 1):S37-S43.
    • (1999) J Hypertens , vol.17 , Issue.1 SUPPL.
    • Burnett Jr., J.C.1
  • 19
    • 0026776795 scopus 로고
    • A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps)
    • Schweitz H, Vigne P, Moinier D, Frelin C, Lazdunski M: A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps). J Biol Chem 1992;267:13928-13932.
    • (1992) J Biol Chem , vol.267 , pp. 13928-13932
    • Schweitz, H.1    Vigne, P.2    Moinier, D.3    Frelin, C.4    Lazdunski, M.5
  • 21
    • 0033013924 scopus 로고    scopus 로고
    • A rationale for treatment of endothelial dysfunction in hypertension
    • Ruschitzka F, Corti R, Noll G, Lüscher TF: A rationale for treatment of endothelial dysfunction in hypertension. J Hypertens 1999;17(suppl 1):S25-S35.
    • (1999) J Hypertens , vol.17 , Issue.1 SUPPL.
    • Ruschitzka, F.1    Corti, R.2    Noll, G.3    Lüscher, T.F.4
  • 22
    • 0032430953 scopus 로고    scopus 로고
    • C-type natriuretic peptide: The endothelial component of the natriuretic peptide system
    • Chen HH, Burnett JC Jr: C-type natriuretic peptide: the endothelial component of the natriuretic peptide system. J Cardiovasc Pharmacol 1998;32(suppl 3):S22-S28.
    • (1998) J Cardiovasc Pharmacol , vol.32 , Issue.3 SUPPL.
    • Chen, H.H.1    Burnett Jr., J.C.2
  • 23
    • 0027292857 scopus 로고
    • Endopeptidase-24.11 and its inhibitors: Potential therapeutic agents for edematous disorders and hypertension
    • Wilkins MR, Unwin RJ, Kenny AJ: Endopeptidase-24.11 and its inhibitors: potential therapeutic agents for edematous disorders and hypertension. Kidney Int 1993;43:273-285.
    • (1993) Kidney Int , vol.43 , pp. 273-285
    • Wilkins, M.R.1    Unwin, R.J.2    Kenny, A.J.3
  • 24
    • 0024538318 scopus 로고
    • Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones
    • Erdös EG, Skidgel RA: Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones. FASEB J 1989;3:145-151.
    • (1989) FASEB J , vol.3 , pp. 145-151
    • Erdös, E.G.1    Skidgel, R.A.2
  • 26
    • 0025892599 scopus 로고
    • Differential regional expression of three natriuretic peptide receptor genes within primate tissues
    • Wilcox JN, Augustine A, Goeddel DV, Lowe DG: Differential regional expression of three natriuretic peptide receptor genes within primate tissues. Mol Cell Biol 1991;11:3454-3462.
    • (1991) Mol Cell Biol , vol.11 , pp. 3454-3462
    • Wilcox, J.N.1    Augustine, A.2    Goeddel, D.V.3    Lowe, D.G.4
  • 28
    • 0025007287 scopus 로고
    • Urodilantin, a natriuretic factor from kidneys, can modify renal and cardiovascular function in men
    • Saxenhofer H, Raselli A, Weidmann P, Forssmann WG, Bub A, Ferrari P, Shaw SG: Urodilantin, a natriuretic factor from kidneys, can modify renal and cardiovascular function in men. Am J Physiol 1990;259(Pt 2): F832-F838.
    • (1990) Am J Physiol , vol.259 , Issue.2 PART
    • Saxenhofer, H.1    Raselli, A.2    Weidmann, P.3    Forssmann, W.G.4    Bub, A.5    Ferrari, P.6    Shaw, S.G.7
  • 29
    • 33751275283 scopus 로고    scopus 로고
    • Contribution of angiotensin-converting enzyme to the cardiac metabolism of bradykinin: An interspecies study
    • Blais CJ, Drapeau G, Raymond P, Lamontagne D, Gervais N, Venneman I, Adam A: Contribution of angiotensin-converting enzyme to the cardiac metabolism of bradykinin: an interspecies study. Am J Physiol 1997; 273(Pt 2):H2263-H2271.
    • (1997) Am J Physiol , vol.273 , Issue.2 PART
    • Blais, C.J.1    Drapeau, G.2    Raymond, P.3    Lamontagne, D.4    Gervais, N.5    Venneman, I.6    Adam, A.7
  • 30
    • 0024437204 scopus 로고
    • Role of angiotensin converting enzyme and other peptidases in in vivo metabolism of kinins
    • Ishida H, Scicli AG, Carretero OA: Role of angiotensin converting enzyme and other peptidases in in vivo metabolism of kinins. Hypertension 1989;14:322-327.
    • (1989) Hypertension , vol.14 , pp. 322-327
    • Ishida, H.1    Scicli, A.G.2    Carretero, O.A.3
  • 32
    • 0029619616 scopus 로고
    • Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure
    • Trippodo NC, Robl JA, Asaad MM, Bird JE, Panchal BC, Schaeffer TR, Fox M, Giancarli MR, Cheung HS: Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure. J Pharmacol Exp Ther 1995;275:745-752.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 745-752
    • Trippodo, N.C.1    Robl, J.A.2    Asaad, M.M.3    Bird, J.E.4    Panchal, B.C.5    Schaeffer, T.R.6    Fox, M.7    Giancarli, M.R.8    Cheung, H.S.9
  • 33
    • 0025973972 scopus 로고
    • Antihypertensive activity during inhibition of neutral endopeptidase and angiotensin converting enzyme
    • Seymour AA, Swerdel JN, Abboa-Offei B: Antihypertensive activity during inhibition of neutral endopeptidase and angiotensin converting enzyme. J Cardiovasc Pharmacol 1991;17:456-465.
    • (1991) J Cardiovasc Pharmacol , vol.17 , pp. 456-465
    • Seymour, A.A.1    Swerdel, J.N.2    Abboa-Offei, B.3
  • 34
    • 0031785220 scopus 로고    scopus 로고
    • Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme in rats with hypertension and diabetes mellitus
    • Tikkanen T, Tikkanen I, Rockwell MD, Allen TJ, Johnston CI, Cooper ME, Burrell LM: Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme in rats with hypertension and diabetes mellitus. Hypertension 1998;32:778-785.
    • (1998) Hypertension , vol.32 , pp. 778-785
    • Tikkanen, T.1    Tikkanen, I.2    Rockwell, M.D.3    Allen, T.J.4    Johnston, C.I.5    Cooper, M.E.6    Burrell, L.M.7
  • 35
    • 0031776557 scopus 로고    scopus 로고
    • Protective effects of CGS 30440, a combined angiotensin-converting enzyme inhibitor and neutral endopeptidase inhibitor, in a model of chronic renal failure
    • Cohen DS, Mathis JE, Dotson RA, Graybill SR, Wosu NJ: Protective effects of CGS 30440, a combined angiotensin-converting enzyme inhibitor and neutral endopeptidase inhibitor, in a model of chronic renal failure. J Cardiovasc Pharmacol 1998;32:87-95.
    • (1998) J Cardiovasc Pharmacol , vol.32 , pp. 87-95
    • Cohen, D.S.1    Mathis, J.E.2    Dotson, R.A.3    Graybill, S.R.4    Wosu, N.J.5
  • 36
    • 0025719871 scopus 로고
    • Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure
    • Margulies KB, Perrella MA, McKinley LJ, Burnett JCJ: Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure. J Clin Invest 1991;88:1636-1642.
    • (1991) J Clin Invest , vol.88 , pp. 1636-1642
    • Margulies, K.B.1    Perrella, M.A.2    McKinley, L.J.3    Burnett, J.C.J.4
  • 37
    • 0027519535 scopus 로고
    • Systemic hemodynamics, renal function and hormonal levels during inhibition of neutral endopeptidase 3.4.24.11 and angiotensin-converting enzyme in conscious dogs with pacing-induced heart failure
    • Seymour AA, Asaad MM, Lanoce VM, Langenbacher KM, Fennell SA, Rogers WL: Systemic hemodynamics, renal function and hormonal levels during inhibition of neutral endopeptidase 3.4.24.11 and angiotensin-converting enzyme in conscious dogs with pacing-induced heart failure. J Pharmacol Exp Ther 1993;266:872-883.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 872-883
    • Seymour, A.A.1    Asaad, M.M.2    Lanoce, V.M.3    Langenbacher, K.M.4    Fennell, S.A.5    Rogers, W.L.6
  • 38
    • 0027448911 scopus 로고
    • Combined inhibition of neutral endopeptidase and angiotensin converting enzyme in cardiomyopathic hamsters with compensated heart failure
    • Trippodo NC, Fox M, Natarajan V, Panchal BC, Dorso CR, Asaad MM: Combined inhibition of neutral endopeptidase and angiotensin converting enzyme in cardiomyopathic hamsters with compensated heart failure. J Pharmacol Exp Ther 1993;267:108-116.
    • (1993) J Pharmacol Exp Ther , vol.267 , pp. 108-116
    • Trippodo, N.C.1    Fox, M.2    Natarajan, V.3    Panchal, B.C.4    Dorso, C.R.5    Asaad, M.M.6
  • 39
    • 0002987505 scopus 로고
    • Dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase: Design and therapeutic rationale
    • Laragh JH, Brenner BM (eds): New York, Raven Press
    • Flynn GA, French JF, Dage RC: Dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase: design and therapeutic rationale, in Laragh JH, Brenner BM (eds): Hypertension: Pathophysiology, Diagnosis, and Management. New York, Raven Press, 1995, pp 3099-3114.
    • (1995) Hypertension: Pathophysiology, Diagnosis, and Management , pp. 3099-3114
    • Flynn, G.A.1    French, J.F.2    Dage, R.C.3
  • 40
    • 0028856125 scopus 로고
    • Comparison of candoxatril and atrial natriuretic factor in healthy men. Effects on hemodynamics, sympathetic activity, heart rate variability, and endothelin
    • Andó S, Rahman MA, Butler GC, Senn BL, Floras JS: Comparison of candoxatril and atrial natriuretic factor in healthy men. Effects on hemodynamics, sympathetic activity, heart rate variability, and endothelin. Hypertension 1995;26(Pt 2):1160-1166.
    • (1995) Hypertension , vol.26 , Issue.2 PART , pp. 1160-1166
    • Andó, S.1    Rahman, M.A.2    Butler, G.C.3    Senn, B.L.4    Floras, J.S.5
  • 41
    • 0026764995 scopus 로고
    • Acute inhibition of endopeptidase 24.11 in essential hypertension: SCH 34826 enhances atrial natriuretic peptide and natriuresis without lowering blood pressure
    • Richards AM, Crozier IG, Espiner EA, Ikram H, Yandle TG, Kosoglou T, Rallings M, Frampton C: Acute inhibition of endopeptidase 24.11 in essential hypertension: SCH 34826 enhances atrial natriuretic peptide and natriuresis without lowering blood pressure. J Cardiovasc Pharmacol 1992;20:735-741.
    • (1992) J Cardiovasc Pharmacol , vol.20 , pp. 735-741
    • Richards, A.M.1    Crozier, I.G.2    Espiner, E.A.3    Ikram, H.4    Yandle, T.G.5    Kosoglou, T.6    Rallings, M.7    Frampton, C.8
  • 43
    • 0026481029 scopus 로고
    • Effect of inhibition of endopeptidase 24.11 on responses to angiotensin II in human volunteers
    • Richards AM, Wittert GA, Espiner EA, Yandle TG, Ikram H, Frampton C: Effect of inhibition of endopeptidase 24.11 on responses to angiotensin II in human volunteers. Circ Res 1992;71:1501-1507.
    • (1992) Circ Res , vol.71 , pp. 1501-1507
    • Richards, A.M.1    Wittert, G.A.2    Espiner, E.A.3    Yandle, T.G.4    Ikram, H.5    Frampton, C.6
  • 44
    • 0027173606 scopus 로고
    • Chronic inhibition of endopeptidase 24.11 in essential hypertension: Evidence for enhanced atrial natriuretic peptide and angiotensin II
    • Richards AM, Wittert GA, Crozier IG, Espiner EA, Yandle TG, Ikram H, Frampton C: Chronic inhibition of endopeptidase 24.11 in essential hypertension: evidence for enhanced atrial natriuretic peptide and angiotensin II. J Hypertens 1993;11:407-416.
    • (1993) J Hypertens , vol.11 , pp. 407-416
    • Richards, A.M.1    Wittert, G.A.2    Crozier, I.G.3    Espiner, E.A.4    Yandle, T.G.5    Ikram, H.6    Frampton, C.7
  • 46
    • 0029809157 scopus 로고    scopus 로고
    • Recent advances in the development of dual angiotensin-converting enzyme and neutral endopeptidase inhibitors
    • Fink CA: Recent advances in the development of dual angiotensin-converting enzyme and neutral endopeptidase inhibitors. Exp Opin Ther Patents 1996;6:1147-1164.
    • (1996) Exp Opin Ther Patents , vol.6 , pp. 1147-1164
    • Fink, C.A.1
  • 47
    • 0031666168 scopus 로고    scopus 로고
    • Combined inhibition of neutral endopeptidase and angiotensin-converting enzyme by sampatrilat in essential hypertension
    • Wallis EJ, Ramsay LE, Hettiarachchi J: Combined inhibition of neutral endopeptidase and angiotensin-converting enzyme by sampatrilat in essential hypertension. Clin Pharmacol Ther 1998;64:439-449.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 439-449
    • Wallis, E.J.1    Ramsay, L.E.2    Hettiarachchi, J.3
  • 48
    • 0033059782 scopus 로고    scopus 로고
    • Sustained antihypertensive actions of a dual angiotensin-converting enzyme neutral endopeptidase inhibitor, sampatrilat, in black hypertensive subjects
    • Norton G, Woodiwiss A, Hartford C, Trifunovic B, Middlemost S, Lee A, Allen MJ: Sustained antihypertensive actions of a dual angiotensin-converting enzyme neutral endopeptidase inhibitor, sampatrilat, in black hypertensive subjects. Am J Hypertens 1999;12: 563-571.
    • (1999) Am J Hypertens , vol.12 , pp. 563-571
    • Norton, G.1    Woodiwiss, A.2    Hartford, C.3    Trifunovic, B.4    Middlemost, S.5    Lee, A.6    Allen, M.J.7
  • 50
    • 0000877531 scopus 로고    scopus 로고
    • Simultaneous inhibition of neutral endopeptidase and angiotensin converting enzyme by omapatrilat increased survival in heart failure hamsters greater than ACE inhibition
    • Trippodo NC, Fox M, Monticello TM, Panchal BC, Asaad MM: Simultaneous inhibition of neutral endopeptidase and angiotensin converting enzyme by omapatrilat increased survival in heart failure hamsters greater than ACE inhibition (abst 4095). Circulation 1998;98:I-781.
    • (1998) Circulation , vol.98
    • Trippodo, N.C.1    Fox, M.2    Monticello, T.M.3    Panchal, B.C.4    Asaad, M.M.5
  • 52
    • 0001643315 scopus 로고    scopus 로고
    • Effects of BMS-186716, a new dual metalloprotease inhibitor, on pharmacodynamic markers of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) activity in healthy men
    • Vesterqvist O, Liao W, Manning JA, Uderman H, Delaney C, Beierle F, Swanson BN: Effects of BMS-186716, a new dual metalloprotease inhibitor, on pharmacodynamic markers of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) activity in healthy men (abst PIV-46). Clin Pharmacol Ther 1997; 61:230.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 230
    • Vesterqvist, O.1    Liao, W.2    Manning, J.A.3    Uderman, H.4    Delaney, C.5    Beierle, F.6    Swanson, B.N.7
  • 53
    • 0000326308 scopus 로고    scopus 로고
    • Supine mean arterial blood pressure (MAP) lowering and oral tolerance of BMS-186716, a new dual metalloprotease inhibitor of angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP), in healthy male subjects
    • Liao W, Delaney C, Smith R, Lubin S, McNulty S, Davis K, Meier A, Uderman H: Supine mean arterial blood pressure (MAP) lowering and oral tolerance of BMS-186716, a new dual metalloprotease inhibitor of angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP), in healthy male subjects (abst PIV-45). Clin Pharmacol Ther 1997;61:229.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 229
    • Liao, W.1    Delaney, C.2    Smith, R.3    Lubin, S.4    McNulty, S.5    Davis, K.6    Meier, A.7    Uderman, H.8
  • 54
    • 0000720811 scopus 로고    scopus 로고
    • The safety and 24-hour antihypertensive efficacy of the vasopeptidase inhibitor omapatrilat: A pilot study
    • Ruddy M, Guthrie R, Papademetriou V, Moulton K, Saini R: The safety and 24-hour antihypertensive efficacy of the vasopeptidase inhibitor omapatrilat: a pilot study (abst D059). Am J Hypertens 1999;12(Pt 2):125A.
    • (1999) Am J Hypertens , vol.12 , Issue.2 PART
    • Ruddy, M.1    Guthrie, R.2    Papademetriou, V.3    Moulton, K.4    Saini, R.5
  • 55
    • 0000720810 scopus 로고    scopus 로고
    • Efficacy and safety of omapatrilat, a vasopeptidase inhibitor
    • Zusman R, Atlas S, Kochar M, Adler E, Levy E: Efficacy and safety of omapatrilat, a vasopeptidase inhibitor (abst D060). Am J Hypertens 1999;12(Pt 2):125A.
    • (1999) Am J Hypertens , vol.12 , Issue.2 PART
    • Zusman, R.1    Atlas, S.2    Kochar, M.3    Adler, E.4    Levy, E.5
  • 56
    • 0000836396 scopus 로고    scopus 로고
    • Antihypertensive dose response of omapatrilat, a vasopeptidase inhibitor, in mild to moderate hypertension
    • Weber MA, Chang PI, Reeves RA, Moulton K, Pouleur H: Antihypertensive dose response of omapatrilat, a vasopeptidase inhibitor, in mild to moderate hypertension (abst D046). Am J Hypertens 1999;12(Pt 2):122A.
    • (1999) Am J Hypertens , vol.12 , Issue.2 PART
    • Weber, M.A.1    Chang, P.I.2    Reeves, R.A.3    Moulton, K.4    Pouleur, H.5
  • 57
    • 0002448550 scopus 로고    scopus 로고
    • Monotherapy treatment success rate of omapatrilat, a vasopeptidase inhibitor, compared with lisinopril and amlodipine in mild to moderate hypertension
    • Black HR, Chang PI, Reeves RA, Cooper W, Pouleur H: Monotherapy treatment success rate of omapatrilat, a vasopeptidase inhibitor, compared with lisinopril and amlodipine in mild to moderate hypertension (abst). Am J Hypertens 1999;12(Pt 2):26A.
    • (1999) Am J Hypertens , vol.12 , Issue.2 PART
    • Black, H.R.1    Chang, P.I.2    Reeves, R.A.3    Cooper, W.4    Pouleur, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.