An HPLC method for the determination of diastereomeric prodrug RS-79070-004 in human plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 21, Issue 3, 1999, Pages 647-656

  Chan, Rebecca ^a   Lafargue, Joann ^a   Reeve, Russell L ^b   Tam, Yuen ^a   Tarnowski, Thomas ^a  

^a ROCHE BIOSCIENCE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Column switching; Diastereomer; Ganciclovir; Prodrug; Reverse phase liquid chromatography

Indexed keywords

GANCICLOVIR DERIVATIVE; PRODRUG; RS 79070 004; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; AUTOMATION; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTIVIRAL AGENTS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GANCICLOVIR; HUMANS; PRODRUGS; QUALITY CONTROL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM;

EID: 0032712340     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(99)00160-0     Document Type: Article

References (3)

1. Markham A., Faulds D. Drugs. 48:1994;455-484.
2. Griffy K. AIDS. 10(Suppl. 4):1996;S3-S6.
3. F. Chu, C-H Kiang, M-L. Sung, B. Huang, T. Tarnowski, J. Pharm. Biomed. Anal. (1999) submitted for publication.