Dopamine receptor blockade in the nucleus accumbens inhibits maternal retrieval and licking, but enhances nursing behavior in lactating rats

Physiology and Behavior

Volumn 67, Issue 5, 1999, Pages 659-669

  Keer, S E ^a   Stern, J M ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Dorsomedial striatum; Maternal behavior; Mesolimbic dopamine system; Nigrostriatal dopamine system; Ventral striatum

Indexed keywords

DOPAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; FLUPENTIXOL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALEPSY; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; INTRACEREBRAL DRUG ADMINISTRATION; LACTATION; LIMBIC SYSTEM; MATERNAL BEHAVIOR; MATERNAL CARE; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT;

EID: 0032712324     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(99)00116-X     Document Type: Article

References (74)

1. nd ed:1995;173-182 Academic Press, San Diego.
2. Ben-Jonathan N. Dopamine. A prolactin-inhibiting hormone Endocr. Rev. 6:1985;564-589.
3. Blackburn J.R., Pfaus J.G., Phillips A.G. Dopamine functions in appetitive and defensive behaviors. Prog. Neurobiol. 39:1992;247-279.
4. Brog J.S., Salyapongse A., Deutch A.Y., Zahm D.S. The patterns of afferent innervation of the core and shell in the "accumbens" part of the rat ventral striatum. Immunohistochemical detection of retrogradely transported fluoro-gold J. Comp. Neurol. 338:1993;255-278.
5. Caggiula A.R., Herndon J.J. Jr., Scanlon R., Greenstone D., Bradshaw W., Sharp D. Dissociation of active from immobility components of sexual behavior in female rats by central 6-hydroxydopamine. Implications for CA involvement in sexual behavior and sensorimotor responsiveness Brain Res. 172:1979;505-520.
6. Carlezon W.A., Wise R.A. Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex. J. Neurosci. 16:1996;3112-3122.
7. Cho J., West M.O. Distributions of single neurons related to body parts in the lateral striatum of the rat. Brain Res. 756:1997;241-246.
8. 2 receptors in the nucleus accumbens in jaw movements of rats. A critical role of the shell Eur. J. Pharmacol. 286:1995;41-47.
9. Cooper J.R., Bloom F.E., Roth R.H. The biochemical basis of neuropharmacology. 1991;Oxford University, New York.
10. De Ryck M., Schallert T., Teitelbaum P. Morphine versus haloperidol catalepsy in the rat. A behavioral analysis of postural support mechanisms Brain Res. 201:1980;143-172.
11. Delfs J.M., Kelley A.E. The role of D1 and D2 dopamine receptors in oral stereotypy induced by dopaminergic stimulation of the ventrolateral striatum. Neuroscience. 39:1990;59-67.
12. Divac I., Markowitsch H.J., Pritzel M. Behavioral and anatomical consequences of small intrastriatal injections of kainic acid in the rat. Brain Res. 151:1978;523-532.
13. Deutch A.Y., Cameron D.S. Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell. Neuroscience. 46:1992;49-56.
14. Fallon J.H., Loughlin E.E. Substantia nigra. Paxinos G. The rat nervous system. 2nd ed:1995;215-237 Academic Press, San Diego.
15. Fowler S.C., LaCerra M.M., Ettenberg A. Effects of haloperidol on the biophysical characteristics of operant responding. Implications for motor and reinforcement processes Pharmacol. Biochem. Behav. 25:1986;791-796.
16. Fowler S.C., Liao R.-M., Skjoldagerg P. A new rodent model for neuroleptic-induced pseudoparkinsonism. Low doses of haloperidol increase forelimb tremor in the rat Behav. Neurosci. 104:1990;449-456.
17. Fowler S.C., Mortell C. Low doses of haloperidol interfere with rat tongue extensions during licking. A quantitative analysis Behav. Neurosci. 106:1992;386-395.
18. Gaffori O., Le Moal M. Disruption of maternal behavior and appearance of cannibalism after ventral mesencephalic tegmentum lesions. Physiol. Behav. 23:1979;317-323.
19. Garris P.A., Kilpatrick M., Bunin M.A., Michael D., Walker Q.D., Wightman R.M. Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation. Nature. 398:1999;67-69.
20. Giordano A.L., Johnson A.E., Rosenblatt J.S. Haloperidol-induced disruption of retrieval behavior and reversal with apomorphine in lactating rats. Physiol. Behav. 48:1990;211-214.
21. Hansen S. Maternal behavior of female rats with 6-OHDA lesions in the ventral striatum. Characterization of the pup retrieval deficit Physiol. Behav. 55:1994;615-620.
22. Hansen S., Bergvall H., Nyiredi S. Interaction with pups enhances dopamine release in the ventral striatum of maternal rats. A microdialysis study Pharmacol. Biochem. Behav. 45:1993;673-676.
23. Hansen S., Harthon C., Wallin E., Lofberg L., Svennson K. Mesotelencephalic dopamine system and reproductive behavior in the female rat. Effects of ventral tegmental 6-hydroxydopamine lesions on maternal and sexual responsiveness Behav. Neurosci. 105:1991;588-598.
24. Hansen S., Harthon C., Wallin E., Lofberg L., Svennson K. The effects of 6-OHDA-induced dopamine depletions in the ventral or dorsal striatum on maternal and sexual behavior in the female rat. Pharmacol. Biochem. Behav. 39:1991;71-77.
25. Hansen S., Stanfield E.J., Everitt B.J. The effects of lesions of lateral tegmental noradrenergic neurons on components of sexual behavior and pseudopregnancy in female rats. Neuroscience. 6:1981;1105-1117.
26. nd ed:1995;579-628 Academic Press, San Diego.
27. Heimer L., Zahm D.S., Churchill L., Kalivas P.W., Wohltmann C. Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience. 41:1991;89-125.
28. Keer, S. E.; Protomastro, M.; Stern, J. M.: Dopamine antagonists and maternal behavior: D1 vs. D2 receptor subtypes and sites of action. Conference on Reproductive Behavior, Lehigh University, Bethlehem, PA; June 11-14, 1994.
29. Kelley A.E., Stinus L. Disappearance of hoarding behavior after 6-hydroxydopamine lesions of the mesolimbic dopamine neurons and its reinstatement with L-DOPA. Behav. Neurosci. 99:1985;531-545.
30. Kirkby R.J. Caudate nucleus lesions and maternal behavior in the rat. Psychonom. Sci. 9:1967;601-602.
31. Koene P., Prinssen E.P.M., Cools A.R. Involvement of the nucleus accumbens in oral behavior in the freely moving rat. Eur. J. Pharmacol. 233:1993;151-156.
32. Lonstein J.S., Stern J.M. Role of the midbrain periaqueductal gray in maternal nurturance and aggression. c-fos and electrolytic lesion studies in lactating rats J. Neurosci. 17:1997;3364-3378.
33. Lonstein J.S., Stern J.M. Somatosensory contributions to c-fos activation in the caudal periaqueductal gray of lactating rats. Effects of perioral, rooting, and suckling stimuli from pups Horm. Behav. 32:1997;155-166.
34. Lonstein J.S., Stern J.M. Site and behavioral specificity of periaqueductal gray lesions on postpartum sexual, maternal, and aggressive behaviors in rats. Brain Res. 804:1998;21-35.
35. Lonstein J.S., Simmons D.A., Stern J.M. Functions of the caudal periaqueductal gray in lactating rats. Kyphosis, lordosis, maternal aggression, and fearfulness Behav. Neurosci. 112:1998;1502-1518.
36. Lonstein J.S., Simmons D.A., Swann J.M., Stern J.M. Forebrain expression of c-fos due to active maternal behavior in lactating rats. Neuroscience. 82:1998;267-281.
37. Mittler T., Cho J., Peoples L.L., West M.O. Representation of the body in the lateral striatum of the freely moving rat. Single neurons related to licking Exp. Brain Res. 98:1994;163-167.
38. Mogenson G.P., Jones P., Yim C.Y. From motivation to action. Functional interface between the limbic system and the motor system Prog. Neurobiol. 14:1980;69-97.
39. 3H-norepinephrine into the hypothalamus of the rat. Diffusion into tissue and ventricles Physiol. Behav. 7:1971;743-751.
40. Numan M. Maternal behavior. Knobil E., Neill J.D. The physiology of reproduction. 2nd ed:1994;221-302 Raven, New York.
41. Numan M., Numan M.J. A lesion and neuroanatomical tract-tracing analysis of the role of the bed nucleus of the stria terminalis in retrieval behavior and other aspects of maternal responsiveness in rats. Dev. Psychobiol. 29:1996;23-52.
42. Numan M., Nagle D.S. Preoptic area and substantia nigra interact in the control of maternal behavior in the rat. Behav. Neurosci. 97:1983;120-139.
43. Numan M., Smith H.G. Maternal behavior in rats. Evidence for the involvement of preoptic projections to the ventral tegmental area Behav. Neurosci. 98:1984;712-727.
44. 2 dopamine receptors in neuroleptic catalepsy. Eur. J. Pharmacol. 182:1990;327-334.
45. 2-dependent catalepsy in the rat requires functional NMDA receptors in the corpus striatum, nucleus accumbens and substantia nigra pars reticulata. Brain Res. 777:1977;51-59.
46. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 2nd ed:1986;Academic Press, San Diego.
47. Pellegrino L.J., Pellegrino A.S., Cushman A.J. A stereotaxic atlas of the rat brain. 1979;Academic Press, San Diego.
48. Pfaus J.G., Damsma G., Wenkstern D., Fibiger H.C. Sexual activity increases dopamine transmission in the nucleus accumbens and striatum of female rats. Brain Res. 693:1995;21-30.
49. Pfaus J.G., Phillips A.G. Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat. Behav. Neurosci. 105:1991;727-743.
50. Pfaus J.G., Damsma G., Nomikos G.G., Wenkstern D., Blaha C.D., Phillips A.G., Fibiger H.C. Sexual behavior enhances dopamine transmission in the male rat. Brain Res. 530:1990;345-348.
51. Pisa M. Motor functions of the striatum in the rat. Critical role of the lateral region in tongue and forelimb reaching Neuroscience. 24:1988;453-463.
52. Prinssen E.P.M., Balestra W., Bemelmans F.F.J., Cools A.R. Evidence for the role of the shell of the nucleus accumbens in oral behavior of freely moving rats. J. Neurosci. 14:1994;1555-1562.
53. Robbins T.W., Everitt B.J. Neurobehavioral mechanisms of reward and motivation. Curr. Opin. Neurobiol. 6:1996;228-236.
54. Redgrave P., Prescott T.J., Gurney K. Is the short-latency dopamine response too short to signal reward error? Trends Neurosc. 22:1999;146-152.
55. Salamone J.D. Dopaminergic involvement in activational aspects of motivation. Effects of haloperidol on schedule-induced activity, feeding, and foraging in rats Psychobiology. 16:1988;196-206.
56. Salamone J.D. Complex motor and sensorimotor functions of striatal and accumbens dopamine. Involvement in instrumental behavior processes Psychopharmacology (Berlin). 107:1992;160-174.
57. Salamone J.D., Cousins M.S., Bucher S. Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure. Behav. Brain Res. 65:1994;221-229.
58. Sokolowski J.D., Conlan A.N., Salamone J.D. A microdialysis study of nucleus accumbens core and shell dopamine during operant responding in the rat. Neuroscience. 86:1998;1001-1009.
59. Stern J.M. Maternal behavior. Sensory, hormonal, and neural determinants Brush F.R., Levine S. Psychoendocrinology. 1989;105-226 Academic Press, San Diego.
60. Stern J.M. Multisensory regulation of maternal behavior and masculine sexual behavior. A revised view Neurosci. Biobehav. Rev. 14:1990;183-200.
61. Stern J.M. Nursing posture is induced in haloperidol-treated maternally-naive female and male rats in response to ventrum stimulation from active pups. Horm. Behav. 25:1991;504-517.
62. Stern J.M. Somatosensation and maternal care in Norway rats. Rosenblatt J.S., Snowden C.T. Parental care. Evolution, mechanisms, and adaptive significance. Advances in the study of behavior, Vol 25:1996;243-294 Academic Press, San Diego.
63. Stern J.M., Johnson S.K. Ventral somatosensory determinants of nursing behavior in Norway rats. I. Effects of variations in the quality and quantity of pup stimuli. Physiol. Behav. 47:1990;993-1011.
64. Stern J.M., Keer S.E. Maternal motivation of lactating rats is disrupted by low dosages of haloperidol. Behav. Brain Res. 99:1999;231-239.
65. Stern J.M., Taylor L.A. Haloperidol inhibits maternal retrieval and licking, but facilitates nursing behavior and milk ejection in lactating rats. J. Neuroendocrinol. 3:1991;591-596.
66. Stratford T.R., Kelley A.E. GABA in the nucleus accumbens shell participates in the central regulation of feeding behavior. J. Neurosci. 17:1997;4434-4440.
67. Van den Bos R., Cools A.R. Involvement of the substantia innominata/ventral pallidum complex in transmitting forelimb muscular rigidity evoked from the nucleus accumbens in rats. Neursci. Lett. 103:1989;303-308.
68. Willner P., Scheel-Krüger J. The mesolimbic dopamine system. From motivation to action:1991;John Wiley & Sons, New York.
69. Whittier J.R., Orr A. Hyperkinesia and other physiologic effects of caudate deficit in the adult albino rat. Neurology. 12:1962;529-539.
70. Wilson C., Nomikos G.G., Collu M., Fibiger H.C. Dopaminergic correlates of motivated behavior. Importance of drive J. Neurosci. 15:1995;5169-5178.
71. Wise R.A., Rompre P.P. Brain dopamine and reward. Annu. Rev. Psychol. 40:1989;191-225.
72. Yoshida Y., Ono T., Kawano K., Miyagishi T. Distinct sites of dopaminergic and glutamatergic regulations of haloperidol-induced catalepsy within the rat caudate-putamen. Brain Res. 639:1994;139-148.
73. Zahm D.S., Brog J.S. On the significance of subterritories in the "accumbens" part of the ventral striatum. Neuroscience. 50:1992;751-767.
74. Zahm D.S., Heimer L. Specificity in the efferent projections of the nucleus accumbens in the rat. Comparison of the rostral pole projection patterns with those of the core and shell J. Comp. Neurol. 327:1993;220-232.