Behavioral changes in developing mice after prenatal exposure to paroxetine (Paxil)

American Journal of Obstetrics and Gynecology

Volumn 181, Issue 5 I, 1999, Pages 1166-1171

  Coleman, F H ^a   Christensen, H D ^a   Gonzalez, C L ^a   Rayburn, W F ^a  

^a Dept of Obstetrics and Gynecology ^*  (United States)

Author keywords

Behavior; Mouse; Paroxetine; Pregnancy; Selective serotonin reuptake inhibitors

Indexed keywords

PAROXETINE;

AGGRESSIVENESS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; BEHAVIOR DISORDER; CHEMICAL TERATOGENESIS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; EXPLORATORY BEHAVIOR; FEMALE; FETUS; LOCOMOTION; MALE; MAZE TEST; MOUSE; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; REPRODUCTION; SEX DIFFERENCE; SWIMMING; TASK PERFORMANCE;

EID: 0032711384     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(99)70102-X     Document Type: Conference Paper

References (17)

1. American College of Obstetricians and Gynecologists Depression in women 1993 The College Washington ACOG Technical Bulletin No.: 182
2. LA Schmidt BD Greenberg GB Holzman J. Schulkin Treatment of depression by obstetrician-gynecologists: a survey study Obstet Gynecol 90 1997 296 300
3. KL Dechant SP. Clissold Paroxetine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness Drugs 41 1991 225 253
4. JA Baldwin EJ Davidson AL Pritchard JE. Ridings The reproductive toxicology of paroxetine Acta Psychiatr Scand Suppl 350 1989 37 39
5. Paxil package insert 1995 SmithKline Beecham Pharmaceuticals Mississauga, Ontario
6. W Inman K Kubota G Pearce L. Wilton PEM report number 6 Pharmacoepidemiol Drug Safety 2 1993 393 422
7. NA Kulin A Pastuszak SR Sage B Schick-Boschetto G Spivey M Feldkamp Pregnancy outcome following maternal use of the new selective serotonin reuptake inhibitors: a prospective controlled multicenter study JAMA 279 1998 609 610
8. CV Vorhees KD Acuff-Smith MA Schilling JE Fisher MS Moran J. Buelke-Sam A developmental neurotoxicity evaluation of the effects of prenatal exposure to fluoxetine in rats Fundam Appl Toxicol 23 1994 194 205
9. TM Cabrera G. Battaglia Delayed decreases in brain 5-hydroxytryptamine2A/2C receptor density and function in male rat progeny following prenatal fluoxetine J Pharmacol Exp Ther 269 1994 637 645
10. W Rayburn H Christensen A Sienko C Gonzalez F. Coleman Antenatal betamethasone for fetal lung maturation: selection of a murine model to investigate long-term neurobehavioral effects Neurotoxicol Teratol 18 1996 329 330
11. W Rayburn H Christensen C. Gonzalez A placebo-controlled comparison between betamethasone and dexamethasone for fetal maturation: differences in the neurobehavioral development of mice offspring Am J Obstet Gynecol 176 1997 842 851
12. RE Haddock AM Johnson PF Langley DR Nelson JA Pope DR Thomas Metabolic pathway of paroxetine in animals and man and the comparative pharmacological properties of its metabolites Acta Psychiatr Scand Suppl 350 1980 24 26
13. Paxil Physicians’ desk reference 1994 Medical Economics Montvale (NJ) 2267 2268
14. H Christensen T Kupiec J Jacobsen J Stewart C Gonzalez W. Rayburn Tissue concentration from consumption of paroxetine (Paxil) in mice [abstract] Teratology 20 1998 365
15. WF Rayburn HD Christensen A Sienko C Gonzalez F. Coleman Antenatal betamethasone for fetal lung maturation: selection of a murine model to investigate long-term neurobehavioral effects Neurotoxicol Teratol 18 1996 329 330
16. E Freireich E Gehan D Ray L Schmidt H. Skipper Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man Cancer Chemother 50 1966 219 226
17. S Lightowler G Kennett I Williamson T Blackburn F. Tullock Anxiolytic–like effect of paroxetine in a rat social interaction test Pharmacol Biochem Behav 49 1994 281 285