Superinduction of oxidized tryptophan-inducible cytochrome P450 1A1 by cycloheximide in Hepa lclc7 cells

In Vitro and Molecular Toxicology: Journal of Basic and Applied Research

Volumn 12, Issue 3, 1999, Pages 149-162

  Sindhu, Ram K ^a   Kikkawa, Yutaka ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; COMPLEMENTARY DNA; CYCLOHEXIMIDE; CYTOCHROME P450; DACTINOMYCIN; ETHOXYRESORUFIN DEETHYLASE; MESSENGER RNA; MICROSOME ENZYME; OZONE; TRYPTOPHAN;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CELL GROWTH; CONTROLLED STUDY; ENZYME INDUCTION; GENETIC TRANSCRIPTION; HEPATOMA CELL; LIVER MICROSOME; MICROSOME; MOUSE; NONHUMAN; OXIDATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRAVIOLET IRRADIATION;

EID: 0032710708     PISSN: 10979336     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. BOUCHER, P.D., RUCH, R., and HINES, R.N. (1993). Specific nuclear protein binding to a negative regulatory element of the human CYP1A1 gene. J. Biol. Chem. 268, 17384-17391.
2. DOLPHIN, D. (1988). The generation of radicals during the normal and abnormal functioning of cytochromes P450. Basic Life Sci. 49, 501-507.
3. EKSTRÖM, G., and INGELMAN-SUNDBERG, M. (1984). Cytochrome P450-dependent lipid peroxidation in reconstituted membrane vesicles. Biochem. Pharmacol. 33, 2521-2523.
4. FULLER, R.W. (1987). Pharmacological properties of serotonergic and antidepressant drugs. J. Clin. Psychiatry 48(Suppl.), 5-11.
5. GOERZ, G., MERK, H., BOLSEN, K., TSAMBAOS, D., and BERGER, H. (1983). Influence of chronic UV-light exposure on hepatic and cutaneous monooxygenases. Experientia 39, 385-386.
6. GONDER, J.C., PROCTOR, R.A., and WILL, J.A. (1985). Genetic differences in oxygen toxicity are correlated with cytochrome P-450 inducibility. Proc. Natl. Acad. Sci. USA 82, 6315-6319.
7. GONZALEZ, F.J. (1989). The molecular biology of cytochrome P450s. Pharmacol. Rev. 40, 243-288.
8. 1-450 gene. Nucleic Acids Res. 13, 7269-7288.
9. HANKINSON, O. (1994). A genetic analysis of processes regulating cytochrome P4501A1 expression. Adv. Enzyme Regul. 34, 159-171.
10. HANKINSON, O. (1995). The aryl hydrocarbon receptor complex. Annu. Rev. Pharmacol. Toxicol. 35, 307-340.
11. HAZINSKI, T.A., FRANCE, M., KENNEDY, K.A., and HANSEN, T.N. (1989). Cimetidine reduces hyperoxic lung injury in lambs. J. Appl. Physiol. 67, 2486-2492.
12. HAZINSKI, T.A., KENNEDY, K.A., FRANCE, M., and HANSEN, T.N. (1988). Pulmonary oxygen toxicity in young lambs: Physiological and biochemical effects of endotoxin infusion. J. Appl. Physiol. 65, 1579-1585.
13. HAZINSKI, T.A., NOISIN, E., HAMON, I., and DEMATTEO, A. (1995). Sheep lung cytochromo P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension. J. Clin. Invest. 96, 2083-2089.
14. HELFERICH, W.G., and DENISON, M.S. (1991). Ultraviolet photoproducts of tryptophan can act as dioxin agonists. Mol. Pharmacol. 40, 674-678.
15. HINES, R.N., MATHIS, J.M., and JACOB, C.S. (1988). Identification of multiple regulatory elements on the human cytochrome P450IA1 gene. Carcinogenesis 9, 1599-1605.
16. ISRAEL, D.I., ESTOLANO, M.G., GALEAZZI, D.R., and WHITLOCK, J.P. JR. (1985). Superinduction of cytochrome P1-450 gene transcription by inhibition of protein synthesis in wild type and variant mouse hepatoma cells. J. Biol. Chem. 260, 5648-5653.
17. ISRAEL, D.I., and WHITLOCK, J.P. JR. (1984). Regulation of cytochrome P1-450 gene transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin in wild type and variant mouse hepatoma cells. J. Biol. Chem. 259, 5400-5402.
18. KARENLAMPI, S.O., LEGRAVEREND, C., GUDAS, J.M., CARRAMAMZANA, N., and HANKINSON, O. (1988). A third genetic locus affecting the Ah (dioxin) receptor. J. Biol. Chem. 263, 10111-10117.
19. KELLY, F.J. (1988). Effect of hyperoxic exposure on protein synthesis in the rat. Biochem. J. 249, 609-612.
20. KHATSENKO, O.G., SINDHU, R.K., and KIKKAWA, Y. (1997). Undernutrition during hyperoxic exposure induces CYP2E1 in rat liver. Arch. Toxicol. 71, 684-689.
21. KIKKAWA, Y., YANO, S., and SKOZA, L. (1984). Protective effect of interferon inducers against hyperoxic pulmonary damage. Lab. Invest. 50, 62-71.
22. KOCAREK, T.A., SCHUETZ, E.G., and GUZELIAN, P.S. (1993). Transient induction of cytochrome P450 1A1 mRNA by culture medium component in primary cultures of adult rat hepatocytes. In Vitro Cell. Dev. Biol. 29A, 62-66.
23. LEGRAVEREND, C., HANNAH, R., EISEN, H., OWENS, O., NEBERT, D.W., and HANKINSON, O. (1982). Regulatory gene product of the Ah locus: Characterization of receptor mutants among mouse hepatoma clones. J. Biol. Chem. 257, 6502-6507.
24. LEVINE, R.L. (1983). Oxidative modification of glutamine synthetase. I. Inactivation is due to loss of one histidine residue. J. Biol. Chem. 258, 11823-11827.
25. MUKHTAR, H., DELTITO, B.J., MATGOURANIS, P.M., DAS, M., ASOKAN, P., and BICKERS, D.R. (1986). Additive effects of ultraviolet B and crude coal tar on cutaneous carcinogen metabolism: Possible relevance to the tumorigenicity of the Goeckerman regimen. J. Invest. Dermatol. 87, 348-353.
26. NEBERT, D.W., and GELBOIN, H.V. (1968). Substrate-inducible microsomal aryl hydrocarbon hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. J. Biol. Chem. 243, 6242-6249.
27. NEMOTO, N., and SAKURAI, J. (1991). Increase of CYP1A1 mRNA and AHH activity by inhibitors of either protein or RNA synthesis in mouse hepatocytes in primary culture. Carcinogenesis 12, 2115-2121.
28. NEMOTO, N., SAKURAI, J., TAZAWA, A., and SIKAWA, T. (1989). Proline-dependent expression of aryl hydrocarbon hydroxylase in C57BL/6 mouse hepatocytes in primary culture. Cancer Res. 49, 5863-5869.
29. OKAMATO, T., MITSUHASHI, M., FUJITA, I., SINDHU, R.K., and KIKKAWA, Y. (1993). Induction of cytochrome P450 1Al and 1A2 by hyperoxia. Biochem. Biophys. Res. Commun. 197, 878-885.
30. PAINE, A.J. (1976). Induction of benzo[a]pyrene mono-oxygenase in liver cell culture by the photochemical generation of active oxygen species: evidence for the involvement of singlet oxygen and the formation of a stable inducing intermediate. Biochem. J. 158, 109-117.
31. PAINE, A.J. (1977). Comparison of the photochemical and enzymic generation of excited states of oxygen on the induction of benzo[a]pyrene monooxygenase in liver cell cultures. Chem. Biol. Interact. 16, 309-314.
32. PAINE, A.J., and FRANCIS, J.E. (1980). The induction of benzo[a]pyrene-3-mono-oxygenase by singlet oxygen in liver cell culture is mediated by oxidation products of histidine. Chem. Biol. Interact. 30, 343-353.
33. PERDEW, G.H., and BABBS, C.F. (1991). Production of Ah receptor ligands in rat fecal suspensions containing tryptophan or indole-3-carbinol. Nutr. Cancer 16, 209-218.
34. POHL, R.J., and FOUTS, J.R. (1977). Xenobiotic metabolism in skin of hairless mice exposed to ultraviolet radiation (UV), aroclor 1260, or chlordane. Pharmacologist 19, 200.
35. PROUGH, R.A., BURKE, M.D., and MAYER, R.T. (1978). Direct fluorometric methods for measuring mixed-function oxidase activity. Methods Enzymol. 52, 372-377.
36. PUGA, A., RAYCHAUDHURI, B., SALATA, K., ZHANG, Y.H., and NEBERT, D.W. (1990). Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity. DNA Cell Biol. 9, 425-436.
37. RAHA, A., JOYCE, T., GUSKY, S., and BRESNICK, E. (1995). Glycine N-methyltransferase is a mediator of cytochrome P4501A1 gene expression. Arch. Biochem. Biophys. 322, 395-404.
38. RANNUG, A., RANNUG, U., ROSENKRANZ, H.S., WINQVIST, L., WESTERHOLM, R., AGURELL, E., and GRAFSTROM, A.K. (1987). Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances. J. Biol. Chem. 262, 15422-15427.
39. RANNUG, A., RANNUG, U., SJÖBERG, U., LI, H., WESTERHOLM, R., and BERGMAN, J. (1995). Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem. Biol. 2, 841-845.
40. RAYCHAUDHURI, B., NEBERT, D.W., and PUGA, A. (1990). The murine Cyp1a1 gene negatively regulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery. Mol. Endocrinol. 4, 1773-1781.
41. SINDHU, R.K., RASMUSSEN, R.E., and KIKKAWA, Y. (1999). Induction of cytochrome P450 1A1 by ozone-oxidized tryptophan in Hepa lclc7 cells. Adv. Exp. Med. Biol. (in press).
42. SINDHU, R.K, MITSUHASHI, M., and KIKKAWA, Y. (1996b). Inhibition of cytochrome P450 1A1 by antisense phosphorothioate oligonucleotide in Hepa lclc7 cells. Biochem. Biophys. Res. Commun. 229, 673-680.
43. SINDHU, R.K., REISZ-PORSZASZ, S., HANKINSON, O., and KIKKAWA, Y. (1996a). Induction of cytochrome P4501A1 by photooxidized tryptophan in Hepa lclc7 cells. Biochem. Pharmacol. 52, 1883-1893.
44. STERLING, K., WEAVER, J., HO, K.L., XU, L.C., and BRESNICK, E. (1993). Rat CYP1A1 negative regulatory element: Biological activity and interaction with a protein from liver and hepatoma cells. Mol. Pharmacol. 44, 560-568.
45. TRACEWELL, W., DESJARDINS, J., and IVERSEN, P. (1995). In vivo modulation of the rat cytochrome P450 1A1 by double stranded phosphorothioate oligodeoxynucleotides. Toxicol. Appl. Pharmacol. 135, 179-184.
46. VAZ, A.D.N., ROBERTS, E.S., and COON, M.J. (1988). Radical intermediates in the catalytic cycles of cytochrome P450. Basic Life Sci. 49, 501-507.
47. WHITLOCK, J.P., JR., and GELBOIN, H.V. (1973). Induction of aryl hydrocarbon (benzo[a]pyrene) hydroxylase in liver cell culture by temporary inhibition of protein synthesis. J. Biol. Chem. 248, 6114-6121.
48. YAN, R., SINDHU, R.K., and KIKKAWA, Y. (1999). Effect of ozone-oxidized tryptophan on [Ah]gene battery enzymes in Hepa lclc7 cells. In Vitro Mol. Toxicol. 12, 33-46.