Contraceptive efficacy of daily administration of 0.5 mg mifepristone

Human Reproduction

Volumn 14, Issue 11, 1999, Pages 2788-2790

  Marions, Lena ^a   Viski, Sandor ^b   Gemzell Danielsson, Kristina ^a   Resch, Bela A ^b   Swahn, Marja Liisa ^a   Bygdeman, Marc ^a   Kovâcs, László ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

Antiprogestin; Contraception; Implantation; Mifepristone

Indexed keywords

MIFEPRISTONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTRACEPTION; ENDOMETRIUM; FEMALE; HUMAN; NIDATION; ORAL DRUG ADMINISTRATION; OVULATION; SIDE EFFECT;

EID: 0032710025     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/14.11.2788     Document Type: Article

References (24)

1. Aitken, R.J. (1979) The hormonal control of implantation. Ciba Foundation Symposium, 64, 53-74.
2. Batista, M.C., Cartledge, T.P., Zellmer, A.W. et al. (1992) Delayed endometrial maturation induced by daily administration of the antiprogestin RU 486: a potential new contraceptive strategy. Am. J. Obstet. Gynecol., 167, 60-65.
3. Baulieau, E.E. (1991) RU 486, an antisteroid molecule: Cellular mechanism and clinical use. In Hardy, M.A. and Kinne, R.K.H. (eds) Biology and Medicine in the 21st Century. Issues Biomed., Karger, Basel, 15, 127-157.
4. Croxatto, H.B., Salvatierra, A.M., Croxatto, H.D. et al. (1993) Effects of continuous treatment with low dose mifepristone throughout one menstrual cycle. Hum. Reprod., 8, 201-207.
5. Croxatto, H.B., Kovacs, L., Massai, R. et al. (1998) Effects of long-term low-dose mifepristone on reproductive function in women. Hum. Reprod., 13, 793-798.
6. Gemzell Danielsson, K., Swahn, M.L., Svalander, P. et al. (1993) Early luteal phase treatment with RU 486 for fertility regulation. Hum. Reprod., 8, 870-873.
7. Gemzell Danielsson, K., Westlund, P., Johannisson, E. et al. (1996) Effect of low weekly doses of mifepristone on ovarian function and endometrial development. Hum. Reprod., 11, 256-264.
8. Gemzell Danielsson, K., Swahn, M.L., Westlund, P. et al. (1997a) Effect of low daily doses of mifepristone on ovarian function and endometrial development. Hum. Reprod., 12, 124-131.
9. Gemzell Danielsson, K., Swahn, M.L. and Bygdeman M. (1997b) The effect of various doses of mifepristone on endometrial leukaemia inhibitory factor expression in the midluteal phase - an immunohistochemical study. Hum. Reprod., 12, 1293-1297.
10. Glasier, A.F., Thong, KJ., Dewar, M. et al. (1992) Mifepristone (RU 486) compared with high-dose estrogen and progesterone emergency postcoital contraception. N. Engl. J. Med., 327, 1041-1044.
11. Ishwad, P.C., Katkam, R.R., Hinduja, I.N. et al. (1993) Treatment with a progesterone antagonist ZK 98.299 delays endometrial development without blocking ovulation in bonnet monkeys. Contraception, 48, 57-70.
12. Katkam, R.R. Gopalkrishnan, K. Chwalisz, K. et al. (1995) Onapristone (ZK 98 299) A potential antiprogestin for endometrial contraception. Am. J. Obstet. Gynecol., 173, 779-787.
13. Lessey, B.A., Castelbaum, A.J., Buck, C.A. et al. (1994b) Further characterisation of endometrial integrins during the menstrual cycle and in pregnancy. Fertil. Steril., 62, 497-506.
14. Liu, H., Garzo, G., Morris, S. et al. (1987) Disruption of follicular maturation and delay of ovulation after administration of the antiprogestin RU 486. J. Clin. Endocrinol. Metab., 65, 1135-1140.
15. Luukkainen, T,. Heikinheimo, O., Haukkamaa, M. et al. (1988) Inhibition of folliculogenesis and ovulation by the antiprogesterone RU 486. Fertil. Steril., 49, 961-963.
16. Marions, L., Gemzell Danielsson, K., Swahn, M.L. et al. (1998a) Contraceptive efficacy of low doses of mifepristone. Fertil. Steril., 70, 813-816.
17. Marions, L., Gemzell Danielsson, K. and Bygdeman, M. (1998b) The effect of antiprogestin on integrin expression in human endometrium - an immunohistochemical study. Mol. Hum. Reprod., 4, 491-495.
18. Moguilewsky, M. and Philibert, D. (1985) Biochemical profile of RU 486. In Baulieu, E.E. and Segal, S.J. (eds) The Antiprogestin Steroid RU 486 and Human Fertility Control. Plenum Press, New York, pp. 87-97.
19. Shoupe, D., Mishell, D.R., Page, M.A. et al. (1987) Effects of the antiprogesteron RU 486 in normal women. II Administration in the late follicular phase. Am. J. Obstet. Gynecol., 157, 1421-1426.
20. Stewart, C.L., Kaspar, P., Brunet, L.J. et al. (1992) Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature, 359, 76-79.
21. Swahn, M.L., Johannisson, E., Daniore, V. et al. (1988) The effect of RU 486 administered during the proliferative and secretory phase of the cycle on the bleeding pattern, hormonal parameters and the endometrium. Hum. Reprod., 3, 915-921.
22. Swahn, M.L. Bygdeman, M., Xing, S. et al. (1990) The effect of RU 486 administered during the early luteal phase on bleeding pattern, hormonal parameters and endometrium. Hum. Reprod., 54, 02-408.
23. Webb, A.M.C., Russel, J. and Elstein, M. (1992) Comparison of Yuzpe regimen, danazol and mifepristone (RU 486) in oral postcoital contraception. Br. Med. J. 305, 927-931.
24. Wilcox, A.J., Weinberg, C.R. and Baird, D.D. (1995) Timing of sexual intercourse in relation to ovulation. N. Engl. J. Med., 333, 1517-1521.