Transport of N(G)-nitro-L-arginine across intestinal brush border membranes by Na+-dependent and Na+-independent amino acid transporters

Pharmaceutical Research

Volumn 16, Issue 11, 1999, Pages 1770-1774

  Hatanaka, Takahiro ^a   Nabuchi, Yoshiaki ^a   Ushio, Hidetoshi ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Basic amino acid transport; Intestinal brush border membrane vesicles; N(G) nitro L arginine; Neutral amino acid transport

Indexed keywords

N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; SODIUM ION;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DOG; DRUG POTENCY; INTESTINE BRUSH BORDER; MATHEMATICAL COMPUTING; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID TRANSPORT SYSTEMS; AMINO ACIDS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; INTESTINE, SMALL; MICROVILLI; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITROARGININE; SODIUM; TIME FACTORS;

EID: 0032708702     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018970419075     Document Type: Article

References (18)

1. 1. S. Moncada, R. M. J. Palmer, and E. A. Higgs. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:109-142 (1991).
2. 2. R. M. J. Palmer, D. D. Rees, D. S. Ashton, and S. Moncada. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem. Biolophys. Res. Commun. 153:1251-1256 (1988).
3. 3H]-arginine uptake into rat cerebellar synaptosomes: kinetics and pharmacology. J. Neurochem. 67:1275-1281 (1996).
4. G-nitro-L-arginine pharmacokinetics in rats after a single intravascular and oral dose: an appearance of secondary concentration time peaks. Drug Metab Disp. 21:962-964 (1993).
5. 5. U. Hopfer. Membrane transport mechanisms for hexoses and amino acids in the small intestine. In L. R. Johnson (ed), Physiology of the Gastrointestinal Tract (2nd Ed), Raven Press, New York, 1987, pp. 1499-1526.
6. 6. B. R. Stevens, J. D. Kaunitz, and E. M. Wright. Intestinal transport of amino acids and sugars: advances using membrane vesicles. Ann. Rev. Physiol. 46:417-433 (1984).
7. 7. V. Ganapathy, M. Brandsch, and F. H. Leibach. Intestinal transport of amino acids and peptides, In L. R. Johnson (ed), Physiology of the Gastrointestinal Tract (4th Ed), Raven Press, New York, 1996, pp. 1773-1794.
8. + in activated macrophages. Biochem. Biophys. Res. Commun. 200:726-731 (1994).
9. 9. K. Schmidt, P. Klatt, and B. Mayer. Uptake of nitric oxide synthase inhibitors by macrophage RAW 264.7 cells. Biochem. J. 301:313-316 (1994).
10. 10. K. Schmidt, B. M. List, P. Klatt, and B. Mayer. Characterization of neuronal amino acid transporters: uptake of nitric oxide synthase inhibitors and implication for their biological effects. J. Neurochem. 64:1469-1475 (1995).
11. 11. K. Schmidt, P. Klatt, and B. Mayer. Characterization of endothelial cell amino acid transport systems involved in the actions of nitric oxide synthase inhibitors. Mol. Pharmacol. 44:615-621 (1993).
12. +-independent transport of L-arginine and L-alamine across dog intestinal brush border membrane vesicles. Comp. Biochem. Physiol. 123B-1:105-113 (1999).
13. 13. B. R. Stevens, H. J. Ross, and E. M. Wright. Multiple transport pathways for neutral amino acids in rabbit jejunal brush border vesicles. J. Membr. Biol. 66:213-225 (1982).
14. 14. G. Cassano, B. Leszcynska, and H. Murer. Transport of L-lysine by rat intestinal brush border membrane vesicles. Pflügers Arch. 397:114-120 (1983).
15. +-gradient dependence of basic amino acid transport into rat intestinal brush border membrane vesicles. Comp. Biochem. Physiol. 78A-3:475-480 (1984).
16. 16. H. N. Christensen. Role of amino acid transport and counter transport in nutrition and metabolism. Physiol. Rev. 70:43-77 (1990).
17. 17. K. Yamaoka, Y. Tanigawra, T. Nakagawa, and T. Uno. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharm. Dyn. 4:879-885 (1981).
18. 18. R. M. Edwards, E. L. Stack, and W. Trizna. Interaction of L-arginine analogs with L-arginine uptake in rat renal brush border membrane vesicles. J. Pharmacol. Exp. Ther. 285:1019-1022 (1998).