Effect of N(G)-nitro-L-arginine methyl ester on autonomic modulation of heart rate variability during hypovolemic shock

Critical Care Medicine

Volumn 27, Issue 10, 1999, Pages 2239-2245

  Goldstein, Brahm ^a   Mickelsen, Deanne ^a   Want, Andrew ^a   Tipton, Rebecca ^a   Cox, Christopher ^a   Woolf, Paul D ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Heart rate power spectra; Hemorrhagic shock; L NAME; N(G) nitro L arginine methyl ester; Plasma catecholamines

Indexed keywords

N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE REGULATION; CARDIOVASCULAR RESPONSE; CATECHOLAMINE BLOOD LEVEL; COMPETITIVE INHIBITION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; HEART RATE; HEART RATE VARIABILITY; HYPOVOLEMIC SHOCK; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; BLOOD PRESSURE; BLOOD VOLUME; CATECHOLAMINES; CIRCADIAN RHYTHM; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; ENZYME INHIBITORS; HEART; HEART RATE; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PROSPECTIVE STUDIES; RABBITS; SHOCK; SYMPATHETIC NERVOUS SYSTEM; VASODILATION;

EID: 0032708496     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199910000-00029     Document Type: Article

References (57)

1. 1. Goldstein B, Woolf PD: The autonomic and neurohumoral response to critical illness. Clin Intensive Care 1997; 7:297-307
2. 2. van Ravenswaaij CMA, Kollee LAA, Hopman JCW, et al: Heart rate variability. Ann Intern Med 1993; 118:436-447
3. 3. Goldstein B, Woolf PD, DeKing DE, et al: Power spectral analysis of heart rate variability and plasma catecholamine levels after postural change and cold pressor testing in man. Pediatr Res 1994; 36:353-363
4. 4. Barman SM, Gebber GL, Calaresu FR: Differential control of sympathetic nerve discharge by the brainstem. Am J Physiol 1984; 247: R513-R519
5. 5. Ninomiya I, Judy WV, Wilson MF: Sympathetic nerve activity to the spleen, kidney and heart in response to baroreceptor input. Am J Physiol 1971; 221:1346-1351
6. 6. Victor RG, Thoren P, Morgan DA, et al: Differential control of adrenal and renal sympathetic nerve activity during hemorrhagic hypotension in rats. Circ Res 1989; 64:686-694
7. 7. Saul JP: Beat-to-beat variations of heart rate reflect modulation of cardiac autonomic outflow. News Physiol Sci 1990;5:32-37
8. 8. Kitney RI, Rompelman O (Eds): The Study of Heart Rate Variability. Oxford, UK: Oxford University Press, 1980
9. 9. Akselrod S, Gordon D, Ubel FA, et al: Power spectral analysis of heart rate fluctuation: A quantitative probe of beat-to-beat cardiovascular control. Science 1981; 213:220-222
10. 10. Akselrod S, Gordon D, Madwed JB, et al: Hemodynamic regulation: Investigation by spectral analysis. Am J Physiol 1985; 249: H867-H875
11. 11. Malliani A, Pagani M, Lombardi F, et al: Cardiovascular neural regulation explored in the frequency domain. Circulation 1991; 84: 482-492
12. 12. Malik M, Camm AJ (Eds): Heart Rate Variability. Armonk, NY: Futura Publishing, 1995
13. 13. Triedman JK, Cohen RJ, Saul JP: Mild hypovolemic stress alters autonomic modulation of heart rate. Hypertension 1993; 21: 236-247
14. 14. Zingarelli B, Squadrito F, Altavilla D, et al: Evidence for a role of nitric oxide in hypovolemic hemorrhagic shock. J Cardiovasc Pharmacol 1992; 19:982-986
15. 15. Szabo C, Thiemermann C: Invited opinion: Role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury. Shock 1994; 2:145-155
16. 16. Moncada S, Higgs A: The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329: 2002-2012
17. 17. Zingarelli B, Caputi AP, Di Rosa M: Dexamethasone prevents vascular failure mediated by nitric oxide in hemorrhagic shock. Shock 1994; 2:210-215
18. 18. Chiu T, Reid IA: Effect of inhibition of nitric oxide synthesis on the cardiovascular and endocrine responses to hemorrhage in conscious rabbits. Hypertens Res 1995; 18: 55-61
19. 19. Szabo C, Mitchell JA, Thiemermann C, et al: Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 1993; 108:786-792
20. 20. Hollenberg SM, Cunnion RE, Zimmerberg J: Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats. Am J Physiol 1993; 264:H660-H663
21. G-nitro-L-arginine on sympathetic and parasympathetic vascular control in vivo. Neuroscience 1994; 62:189-203
22. G-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone? Circ Res 1992; 70:607-611
23. 23. Schulz R, Nava E, Moncada S: Induction and potential biological relevance of a Ca(2 + )-independent nitric oxide synthase in the myocardium. Br J Pharmacol 1992; 105: 575-580
24. 24. Gardiner SM, Kemp PA, March JE, et al: Cardiac and regional haemodynamics, inducible nitric oxide synthase (NOS) activity, and the effects of NOS inhibitors in conscious, endotoxaemic rats. Br J Pharmacol 1995; 116:2005-2016
25. 25. Goldstein B, Kempski MH, Stair DB, et al: Autonomic modulation of heart rate variability during endotoxin shock in rabbits. Crit Care Med 1995; 23:1694-1702
26. 26. Okusawa S, Gelfand JA, Ikejima T, et al: Interleukin 1 induces a shock-like state in rabbits. J Clin Invest 1988; 81:1162-1172
27. 27. Simon GL, Gelfand JA, Connolly RJ, et al: Experimental Bacteroides fragilis bacteremia in a primate model: Evidence that Bacteroides fragilis does not promote the septic shock syndrome. J Trauma 1985; 25: 1156-1162
28. 28. Peuler JD, Johnson GA: Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine, and dopamine. Life Sci 1977; 21:625-636
29. 29. Woolf PD, Hamill RW, Lee LA, et al: The predictive value of catecholamines in assessing outcome in traumatic brain injury. J Neurosurg 1987; 66:875-882
30. 30. Morgan DA, Thoren P, Wilczynski EA, et al: Serotonergic mechanisms mediate renal sympathoinhibition during severe hemorrhage in rats. Am J Physiol 1988; 255: H496-H502
31. 31. Morita H, Vatner S: Effects of hemorrhage on renal nerve activity in conscious dogs. Circ Res 1985; 57:788-793
32. 32. Skoog P, Mansson J, Thoren P: Changes in renal sympathetic outflow during hypotensive hemorrhage in rats. Acta Physiol Scand 1985; 125:655-660
33. 33. Thoren P: Two different inhibitory reflexes elicited from cardiac endings of rats. In: Neural Mechanisms and Cardiovascular Disease. Lown B, Malliani A, Prosdocini M (Eds). New York, Springer, 1986, pp 35-46
34. 34. Morita H, Nishida Y, Motochigawa H, et al: Opiate receptor-mediated decrease in renal nerve activity during hypotensive hemorrhage in conscious rabbits. Circ Res 1988; 63:165-172
35. 35. Secher NH, Jacobsen J, Friedman DB, et al: Bradycardia during reversible hyopvolaemic shock: Associated neural reflex mechanisms and clinical implications. Clin Exp Pharmacol Physiol 1992; 19:733-743
36. 36. Sander-Jensen R, Secher NH, Bie P, et al: Vagal slowing of the heart during haemorrhage: Observations from 20 consecutive hypotensive patients. BMJ 1986; 292:365-366
37. 37. Secher NH, Jensen KS, Werner C, et al: Bradycardia during severe but reversible hypovolemic shock in man. Circ Shock 1984; 14: 267-274
38. 38. Oberg B, White S: The role of vagal cardiac nerves and arterial baroreceptors in the circulatory adjustment to hemorrhage in the cat. Acta Physiol Scand 1970; 80:395-403
39. 39. Koyama S: Central impairment of sympathetic outflow during hemorrhagic shock and endotoxin shock. Prog Clin Biol Res 1988; 264:181-190
40. 40. Korner PI, Oliver JR, Zhu JL, et al: Autonomic, hormonal, and local circulatory effects of hemorrhage in conscious rabbits. Am J Physiol 1990; 258:H229-H239
41. 41. Schadt JC, Ludbrook J: Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals. Am J Physiol 1991; 260:H305-H318
42. 42. Rees DD, Palmer MJ, Moncada S: Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A 1989; 86:3375-3378
43. 43. Koyama S: Central impairment of renal nerve response to stimulation of medullary pressor area in rabbit endotoxic hypotension. Brain Res 1985; 366:217-233
44. 44. Koyama S, Santiesteban HL, Ammons WS, et al: Centrally mediated hypotensive effect of Escherichia coli endotoxin in the anesthetized cat. Circ Shock 1982; 9:557-570
45. 45. Rees DD, Palmer RMJ, Schulz R, et al: Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990; 101:746-752
46. 46. Hart BB, Stanford GC, Ziegler MG, et al: Catecholamines: Study of interspecies variation. Crit Care Med 1989; 17:1203-1222
47. 47. Woolf PD, Akowuah ES, Lee L, et al: Evaluation of the dopamine response to stress in man. J Clin Endocrinol Metab 1983; 56: 245-250
48. 48. Planz G: Adrenaline and noradrenaline concentration in the blood of suprarenal adrenal vein in man with normal blood pressure and with essential hypertension. Klin Wochenschr 1978; 56:1109-1112
49. 49. Brown MJ, Jenner DA, Allison DJ, et al: Variations in individual organ release of noradrenaline by an improved radioenzymatic technique: Limitations of peripheral venous measurements in the assessment of sympathetic nervous activity. Clin Sci 1981; 61: 585-590
50. 50. Saul JP, Yutaka A, Berger RD, et al: Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis. Am J Cardiol 1988; 61:1292-1299
51. 51. Goldstein DS, McCarty R, Polinsky RJ, et al: Relationship between plasma norepinephrine and sympathetic neural activity. Hypertension 1983; 5:552-559
52. G-nitro-L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ Res 1993; 72:387-495
53. 53. Winchell RJ, Hoyt DB: Spectral analysis of heart rate variability in the ICU: A measure of autonomic function. J Surg Res 1996; 63: 11-16
54. 54. Goldstein B, Fiser D, Kelly MM, et al: Decomplexification in critical illness and injury: The relationship between heart rate variability, severity of illness, and outcome. Crit Care Med 1998; 26:352-357
55. 55. Godin PJ, Buchman TG: Uncoupling of biological oscillators: A complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 1996; 24:1107-1116
56. 56. Garrard CS, Kontoyannis DA, Piepoli M: Spectral analysis of heart rate variability in the sepsis syndrome. Clin Auton Res 1993; 3:5-13
57. 57. Piepoli M, Garrard CS, Kontoyannis DA, et al: Autonomic control of the heart and peripheral vessels in human septic shock. Intensive Care Med 1995; 21:112-119